Gene: SLC23A1

9963
SLC23A2|SVCT1|YSPL3
solute carrier family 23 member 1
protein-coding
5q31.2
Ensembl:ENSG00000170482 MIM:603790 Vega:OTTHUMG00000129228 UniprotKB:Q9UHI7
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.964e-1 (AD)  3.217e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF2240.697
ZNF4400.686
ZNF2250.686
ZNF5870.684
MPHOSPH90.682
POLH0.677
ZNF354B0.676
STARD4-AS10.671
ATXN70.671
RNPC30.669

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.355
KLRC2-0.316
BCL7C-0.311
RBP1-0.292
S100A13-0.281
AQP5-0.274
S100A14-0.267
PPP1R14B-0.253
METRN-0.251
RARRES2-0.249

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00126Vitamin CSmall Molecule50-81-7Approved|NutraceuticalTransporter
DB00126Vitamin CSmall Molecule50-81-7Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC23A1 mRNA"22698814|2741311
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of SLC23A1 mRNA"25710175
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC23A1 mRNA"20005886
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SLC23A1 mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC23A1 mRNA"25380136
C0685726-deoxy-6-bromoascorbic acidSLC23A1 protein affects the transport of 6-deoxy-6-bromoascorbic acid15590689
D000082AcetaminophenAcetaminophen results in decreased expression of SLC23A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC23A1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SLC23A1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC23A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC23A1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC23A1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLC23A1 mRNA21757418
D000447AldehydesAldehydes results in decreased expression of SLC23A1 mRNA25014914
D000638AmiodaroneAmiodarone affects the expression of SLC23A1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC23A1 mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in increased expression of SLC23A1 mRNA21281732
D001205Ascorbic AcidSLC23A1 protein results in increased transport of Ascorbic Acid17258485
D001205Ascorbic AcidAscorbic Acid deficiency results in increased expression of SLC23A1 mRNA20471816
D001205Ascorbic AcidAscorbic Acid deficiency results in increased expression of SLC23A1 protein20471816
D001205Ascorbic AcidAscorbic Acid results in decreased expression of SLC23A1 mRNA20471816
D001205Ascorbic AcidAscorbic Acid results in decreased expression of SLC23A1 protein20471816
D001205Ascorbic AcidQuercetin inhibits the reaction [SLC23A1 protein results in increased transport of Ascorbic Acid]11834736
D001205Ascorbic AcidSLC23A1 gene polymorphism affects the abundance of Ascorbic Acid20519558
D001205Ascorbic AcidSLC23A1 protein affects the transport of Ascorbic Acid12381735
D001205Ascorbic AcidSLC23A1 protein results in increased transport of Ascorbic Acid11834736
D001205Ascorbic AcidAscorbic Acid results in increased expression of SLC23A1 mRNA20122894
D001205Ascorbic AcidSLC23A1 protein affects the uptake of Ascorbic Acid11984597
D001553BenzbromaroneBenzbromarone affects the expression of SLC23A1 mRNA19483382
D004958EstradiolEstradiol results in decreased expression of SLC23A1 mRNA20106945
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SLC23A1 mRNA19833106
D001663BilirubinBilirubin results in increased expression of SLC23A1 mRNA18706437
C006780bisphenol Abisphenol A results in decreased expression of SLC23A1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SLC23A1 mRNA26079696
D002994ClofibrateClofibrate affects the expression of SLC23A1 mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC23A1 mRNA24386269
D003042CocaineCocaine affects the expression of SLC23A1 mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC23A1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SLC23A1 mRNA20106945|2163298
C093628cyproconazolecyproconazole results in increased expression of SLC23A1 mRNA22334560
D004008DiclofenacDiclofenac results in increased expression of SLC23A1 mRNA26934552
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SLC23A1 mRNA25380136
C109476epoxiconazoleepoxiconazole results in increased expression of SLC23A1 mRNA22334560
D005001EthionineEthionine affects the expression of SLC23A1 mRNA19483382
D005485FlutamideFlutamide results in increased expression of SLC23A1 mRNA24136188
D017313FenretinideFenretinide results in increased expression of SLC23A1 mRNA28973697
D019266Iron, Dietary"Iron, Dietary affects the expression of SLC23A1 mRNA"15637178
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SLC23A1 mRNA21800402
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC23A1 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC23A1 mRNA25380136
D009853OmeprazoleOmeprazole affects the expression of SLC23A1 mRNA19483382
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of SLC23A1 mRNA]20417186
D010126OzoneOzone results in increased expression of SLC23A1 mRNA20417186
C046012pentanalpentanal results in decreased expression of SLC23A1 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of SLC23A1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SLC23A1 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC23A1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SLC23A1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of SLC23A1 mRNA17426115
C006253pirinixic acidpirinixic acid affects the expression of SLC23A1 mRNA19483382
D017035PravastatinPravastatin results in decreased expression of SLC23A1 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of SLC23A1 mRNA27225895
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SLC23A1 mRNA19833106
D011374ProgesteroneProgesterone results in increased expression of SLC23A1 mRNA22238285
C045950propiconazolepropiconazole results in increased expression of SLC23A1 mRNA21278054|2233456
C005556propionaldehydepropionaldehyde results in decreased expression of SLC23A1 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of SLC23A1 mRNA19483382
D011794QuercetinQuercetin inhibits the reaction [SLC23A1 protein results in increased transport of Ascorbic Acid]11834736
D011794QuercetinQuercetin results in decreased expression of SLC23A1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC23A1 mRNA25895662
C075117squalestatin 1squalestatin 1 affects the expression of SLC23A1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of SLC23A1 mRNA27225895
D013656Taurocholic AcidTaurocholic Acid results in increased expression of SLC23A1 mRNA18706437
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC23A1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC23A1 mRNA20005886
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC23A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC23A1 mRNA21215274
D013853ThioacetamideThioacetamide affects the expression of SLC23A1 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of SLC23A1 mRNA23411599
D014050TolueneToluene affects the expression of SLC23A1 mRNA18653662
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC23A1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of SLC23A1 mRNA17127020
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SLC23A1 mRNA18706437
D014635Valproic AcidValproic Acid affects the expression of SLC23A1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SLC23A1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of SLC23A1 gene29154799
D014639VanadiumVanadium results in increased expression of SLC23A1 mRNA19000753
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC23A1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17474147  25416956  
GO:0008520L-ascorbate:sodium symporter activity-IBA21873635  
GO:0008520L-ascorbate:sodium symporter activity-IDA18094143  
GO:0015081sodium ion transmembrane transporter activity-IDA18094143  
GO:0015205nucleobase transmembrane transporter activity-TAS10395795  
GO:0015229L-ascorbic acid transmembrane transporter activity-IDA10631088  11895172  18247577  18417304  19216494  
GO:0015229L-ascorbic acid transmembrane transporter activity-TAS-  
GO:0033300dehydroascorbic acid transmembrane transporter activity-IBA21873635  
GO:0033300dehydroascorbic acid transmembrane transporter activity-IMP18247577  
GO:0070890sodium-dependent L-ascorbate transmembrane transporter activity-IBA21873635  
GO:0070890sodium-dependent L-ascorbate transmembrane transporter activity-IDA10631088  11895172  15993839  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS9804989  
GO:0006814sodium ion transport-IDA18094143  
GO:0007420brain development-IBA21873635  
GO:0007420brain development-ISS-  
GO:0009636response to toxic substance-IBA21873635  
GO:0009636response to toxic substance-IDA17575980  
GO:0015851nucleobase transport-TAS10395795  
GO:0015882L-ascorbic acid transmembrane transport-IDA10631088  11895172  18247577  18417304  19216494  
GO:0019852L-ascorbic acid metabolic process-TAS-  
GO:0030324lung development-IBA21873635  
GO:0030324lung development-IEA-  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0070837dehydroascorbic acid transport-IMP18247577  
GO:0070904transepithelial L-ascorbic acid transport-IBA21873635  
GO:0070904transepithelial L-ascorbic acid transport-IDA18417304  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA10631088  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10395795  
GO:0005903brush border-IBA21873635  
GO:0009925basal plasma membrane-IBA21873635  
GO:0009925basal plasma membrane-IEA-  
GO:0016020membrane-TAS9804989  
GO:0016324apical plasma membrane-IBA21873635  
GO:0016324apical plasma membrane-IDA15993839  18094143  18247577  18417304  19216494  
GO:0043229intracellular organelle-IDA15993839  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196836Vitamin C (ascorbate) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24708273SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis. (2014 Jun)de Jong TMJ Clin Periodontol