Gene: TNFSF15

9966
TL1|TL1A|TNLG1B|VEGI|VEGI192A
TNF superfamily member 15
protein-coding
9q32
Ensembl:ENSG00000181634 MIM:604052 Vega:OTTHUMG00000021011 UniprotKB:O95150
NG_011488.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.079e-1 (AD)  6.467e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DMBX10.745
RBM470.719
ITK0.716
CHRNB40.708
GIPC30.697
CD1800.69
LRRN4CL0.683
GDNF0.682
ADM20.679
ADH40.669

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.369
ENPP5-0.31
AMER3-0.306
MOXD1-0.295
CKMT1B-0.291
TMEM191C-0.287
EFNA5-0.287
ALOX12B-0.283
NDP-0.283
EMILIN3-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C00358522-hydroxycholesterol22-hydroxycholesterol results in increased expression of TNFSF15 mRNA19426978
C02835824,25-epoxycholesterol"24,25-epoxycholesterol results in increased expression of TNFSF15 mRNA"19426978
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased expression of TNFSF15 mRNA19426978
C0038982-anisidine2-anisidine results in decreased expression of TNFSF15 mRNA28089782
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF15 mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNFSF15 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNFSF15 mRNA24449571
D001151ArsenicArsenic affects the expression of TNFSF15 protein24675094
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFSF15 mRNA17530438
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of TNFSF15 mRNA18192240
C006780bisphenol Abisphenol A affects the expression of TNFSF15 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of TNFSF15 mRNA26496021
C584509C646 compoundC646 compound results in increased expression of TNFSF15 mRNA26191083
D002104CadmiumCadmium results in increased expression of TNFSF15 mRNA21120746
D003024ClozapineClozapine results in decreased expression of TNFSF15 mRNA17346280
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of TNFSF15 mRNA26033743
D003300CopperCopper deficiency results in increased expression of TNFSF15 mRNA26033743
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TNFSF15 mRNA27392435
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of TNFSF15 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of TNFSF15 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of TNFSF15 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TNFSF15 mRNA21592394
C521792DMU-212DMU-212 affects the expression of TNFSF15 mRNA26428916
C001277geldanamycingeldanamycin results in decreased expression of TNFSF15 mRNA26705709
C473027GW 3965GW 3965 results in increased expression of TNFSF15 mRNA19426978
C412815GW 4064GW 4064 results in increased expression of TNFSF15 mRNA26655953
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TNFSF15 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TNFSF15 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFSF15 mRNA25119042
D008154LucanthoneLucanthone results in increased expression of TNFSF15 mRNA21148553
D008727MethotrexateMethotrexate results in increased expression of TNFSF15 mRNA21678067
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNFSF15 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TNFSF15 mRNA"25554681
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TNFSF15 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of TNFSF15 mRNA25119042
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TNFSF15 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFSF15 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TNFSF15 mRNA26272509
C005556propionaldehydepropionaldehyde results in increased expression of TNFSF15 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of TNFSF15 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of TNFSF15 mRNA16202921
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TNFSF15 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TNFSF15 mRNA23806026
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TNFSF15 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TNFSF15 mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of TNFSF15 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFSF15 mRNA20067830
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFSF15 mRNA22298810
C423915TO-901317TO-901317 results in increased expression of TNFSF15 mRNA19426978
D014212TretinoinTretinoin results in increased expression of TNFSF15 mRNA21934132|2383079
C032910triadimefontriadimefon results in decreased expression of TNFSF15 mRNA26705709
D014302Trinitrobenzenesulfonic AcidTNFSF15 protein results in increased susceptibility to Trinitrobenzenesulfonic Acid20980995
D014635Valproic AcidValproic Acid results in increased expression of TNFSF15 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of TNFSF15 mRNA17292431
C088658zoledronic acidzoledronic acid results in increased expression of TNFSF15 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS9434163  
GO:0005125cytokine activity-IEA-  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IDA11911831  
GO:0006955immune response-IEA-  
GO:0007165signal transduction-NAS9872942  
GO:0007250activation of NF-kappaB-inducing kinase activity-IDA11911831  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0042107cytokine metabolic process-IDA11911831  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IDA11911831  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9872942  
GO:0016021integral component of membrane-NAS9872942  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17030188TUCAN (CARD8) genetic variants and inflammatory bowel disease. (2006 Oct)McGovern DPGastroenterology
21730793Influence of Crohn's disease risk alleles and smoking on disease location. (2011 Aug)Chen HDis Colon Rectum