Gene: MED12

9968
ARC240|CAGH45|FGS1|HOPA|MED12S|OHDOX|OKS|OPA1|TNRC11|TRAP230
mediator complex subunit 12
protein-coding
Xq13.1
Ensembl:ENSG00000184634 MIM:300188 Vega:OTTHUMG00000021788 UniprotKB:Q93074
NG_012808.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAZ2A0.885
PHF120.877
SPEN0.876
PLXNB20.872
NEK90.865
PLCG10.864
PHF80.864
NUP1880.864
TYK20.863
EP3000.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.531
OR4F29-0.503
CRH-0.291
KLRC2-0.256
NTS-0.245
PAGE4-0.243
C22orf42-0.242
HCRT-0.239
SIM1-0.234
FOXB1-0.234

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of MED12 mRNA21420995
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MED12 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MED12 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MED12 mRNA"17331233
D001280AtrazineAtrazine results in increased expression of MED12 mRNA25929836
D001280AtrazineAtrazine results in increased expression of MED12 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MED12 gene25435355
C006780bisphenol Abisphenol A affects the expression of MED12 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MED12 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MED12 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of MED12 mRNA26079696
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MED12 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of MED12 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of MED12 mRNA28302478
D000431EthanolMED12 protein affects the susceptibility to Ethanol23342055
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MED12 gene16344459
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MED12 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MED12 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MED12 mRNA28628672
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MED12 mRNA16966085
C046012pentanalpentanal results in decreased expression of MED12 mRNA26079696
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MED12 mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MED12 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of MED12 protein24648495
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MED12 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MED12 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of MED12 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MED12 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of MED12 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MED12 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0003712transcription coregulator activity-IDA10198638  12218053  
GO:0003713transcription coactivator activity-IDA12037571  
GO:0005515protein binding-IPI21293490  23178117  26496610  
GO:0008013beta-catenin binding-IEA-  
GO:0008022protein C-terminus binding-IPI17000779  
GO:0019904protein domain specific binding-IPI11984006  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-NAS10235266  
GO:0038023signaling receptor activity-IDA12218053  
GO:0042809vitamin D receptor binding-NAS10235266  
GO:0046966thyroid hormone receptor binding-IDA10198638  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006367transcription initiation from RNA polymerase II promoter-IDA12218053  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007492endoderm development-IEA-  
GO:0007507heart development-IEA-  
GO:0014003oligodendrocyte development-IEA-  
GO:0014044Schwann cell development-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0019827stem cell population maintenance-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-IMP17000779  
GO:0030518intracellular steroid hormone receptor signaling pathway-IDA11867769  
GO:0030521androgen receptor signaling pathway-IDA12218053  
GO:0036342post-anal tail morphogenesis-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA10198638  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12037571  
GO:0048702embryonic neurocranium morphogenesis-IEA-  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-IEA-  
GO:0090245axis elongation involved in somitogenesis-IEA-  
GO:1990403embryonic brain development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10235267  17000779  
GO:0005654nucleoplasm-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016592mediator complex-IBA21873635  
GO:0016592mediator complex-IDA10198638  12037571  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23342055Novel oxytocin gene expression in the hindbrain is induced by alcohol exposure: transgenic zebrafish enable visualization of sensitive neurons. (2013)Coffey CMPLoS One