Gene: CCS

9973
-
copper chaperone for superoxide dismutase
protein-coding
11q13.2
Ensembl:ENSG00000173992 MIM:603864 Vega:OTTHUMG00000167238 UniprotKB:O14618
NG_008733.1
PubMed
0   ANCO-SNPs
CD|ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.798e-3 (AD)  2.447e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAA10.91
SCRN20.894
ZFPL10.889
PYCR20.885
ACBD40.882
VPS280.88
QTRT10.875
GPS10.872
BRAT10.871
TRMT2A0.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.722
OR4F29-0.679
FER1L6-0.331
SULT1E1-0.305
SPRR4-0.302
GSDMA-0.299
PABPC4L-0.298
GADL1-0.296
MTRNR2L6-0.294
UNC45B-0.28

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0221772,3,2-tetramine"2,3,2-tetramine results in increased expression of CCS protein"12832419
C0221772,3,2-tetramine"Copper Sulfate inhibits the reaction [2,3,2-tetramine results in increased expression of CCS protein]"12832419
C0221772,3,2-tetramine"2,3,2-tetramine results in increased expression of CCS protein"12832419
C0221772,3,2-tetramine"2,3,2-tetramine results in increased stability of CCS protein"12832419
C0221772,3,2-tetramine"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]"12832419
C0221772,3,2-tetramine"[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein"12832419
C0221772,3,2-tetramine"Copper Sulfate inhibits the reaction [2,3,2-tetramine results in increased expression of CCS protein]"12832419
C0221772,3,2-tetramine"lactacystin inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]"12832419
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CCS mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of CCS mRNA"20702594
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CCS mRNA25781201
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of CCS mRNA"20702594
D000082AcetaminophenAcetaminophen affects the expression of CCS mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of CCS mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CCS mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of CCS mRNA28959563
D000638AmiodaroneAmiodarone affects the expression of CCS mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCS mRNA16483693
D052157Aptamers, Nucleotide"Aptamers, Nucleotide inhibits the reaction [CCS protein binds to BACE1 protein]"16888322
D001280AtrazineAtrazine results in decreased expression of CCS mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCS mRNA26001963
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]"12832419
C006780bisphenol Abisphenol A results in increased expression of CCS mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CCS mRNA14729362|1533650
C584509C646 compoundC646 compound results in increased expression of CCS mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCS protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCS mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CCS mRNA27339419
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] affects the expression of CCS mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of CCS mRNA28954213
D002746ChlorpromazineChlorpromazine affects the expression of CCS mRNA25064622
D002994ClofibrateClofibrate affects the expression of CCS mRNA17585979
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CCS mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCS mRNA17602206
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]19039664
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein19039664
C007095cobaltiprotoporphyrinlactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]19039664
C018021cobaltous chlorideCCS protein affects the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]22619252
D003300CopperCCS protein affects the localization of Copper23900152
D003300CopperCCS protein affects the transport of Copper12872841
D003300CopperCCS protein binds to Copper25673218
D003300CopperCCS protein promotes the reaction [Copper results in increased activity of HIF1A protein]17339407
D003300CopperCCS protein promotes the reaction [[Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein]17339407
D003300CopperCopper binds to CCS protein15736924|2172209
D003300CopperCopper deficiency results in increased expression of CCS protein24708542
D003300CopperCopper results in increased expression of CCS protein16627626
D003300CopperCCS protein affects the reaction [Copper binds to and results in increased activity of SOD1 protein]12815046
D003300CopperCCS protein promotes the reaction [Copper binds to and results in increased activity of SOD1 protein]10694572
D003300CopperCopper deficiency results in increased expression of CCS protein19815072|2219002
D003300Copper[SLC31A1 gene mutant form results in increased abundance of CCS protein] which results in decreased abundance of Copper22842628
D003300Copper[Copper deficiency co-treated with Zinc] results in increased expression of CCS18820153
D003300CopperCopper deficiency results in decreased expression of CCS protein12514262
D003300CopperCopper deficiency results in increased expression of CCS protein12832419|2016436
D003300CopperAPBA1 protein binds to [CCS protein binds to Copper]16545469
D003300CopperBACE1 protein binds to [CCS protein binds to Copper]16545469
D003300CopperCCS protein promotes the reaction [Copper binds to SOD1 protein]12514262
D003300CopperCCS protein results in increased transport of Copper18779302|1882015
D003300CopperCopper affects the localization of and affects the degradation of CCS protein16545469
D019327Copper Sulfate[Copper Sulfate co-treated with CP protein] results in increased expression of CCS mRNA17683925
D019327Copper Sulfate"Copper Sulfate inhibits the reaction [2,3,2-tetramine results in increased expression of CCS protein]"12832419
D019327Copper SulfateCopper Sulfate results in decreased expression of CCS mRNA19549813
D019327Copper SulfateCopper Sulfate inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]19039664
D019327Copper Sulfate"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]"12832419
D019327Copper Sulfate"[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein"12832419
D019327Copper Sulfate"Copper Sulfate inhibits the reaction [2,3,2-tetramine results in increased expression of CCS protein]"12832419
D019327Copper Sulfate"lactacystin inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]"12832419
D019327Copper SulfateCopper Sulfate affects the expression of CCS mRNA26368670
D003407CreosoteCreosote results in increased expression of CCS mRNA19389177
C029892cupric chloridecupric chloride results in increased degradation of and results in decreased expression of CCS protein16531609
D003471CuprizoneCuprizone results in increased expression of CCS mRNA26577399
C099343cuprous sulfidecuprous sulfide results in decreased expression of CCS protein24343031
D016572CyclosporineCyclosporine affects the expression of CCS mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of CCS mRNA19770486
C017160cypermethrincypermethrin results in increased expression of CCS mRNA21142847
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of CCS mRNA28659758
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CCS mRNA27392435
D002945CisplatinCisplatin results in increased expression of CCS mRNA27392435
D002945CisplatinCisplatin results in increased expression of CCS mRNA24865317
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CCS mRNA17602206
D004050DitiocarbDitiocarb results in decreased expression of CCS protein20452388
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CCS protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CCS mRNA25064622
D005047EtoposideEtoposide results in increased expression of CCS mRNA21527772
D006418Heme[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]19039664
D006418Heme[Heme binds to HPX protein] which results in increased degradation of CCS protein19039664
D006418Hemelactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]19039664
D006418Heme[[Heme binds to HPX protein] which results in increased expression of HMOX1 mRNA] which affects the expression of CCS mRNA19039664
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CCS mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CCS mRNA14729362
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCS mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CCS mRNA27392435
C544151jinfukangjinfukang results in increased expression of CCS mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CCS mRNA23430699
C067713lactacystinlactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]19039664
C067713lactacystinlactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]19039664
C067713lactacystin"lactacystin inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]"12832419
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] affects the expression of CCS mRNA28954213
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCS mRNA22369063
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CCS mRNA25613284
D014975LuteinLutein results in increased expression of CCS mRNA24865317
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCS mRNA23649840
C051752nefazodonenefazodone results in increased expression of CCS mRNA24136188
D009538NicotineNicotine results in increased expression of CCS protein16627626
C464660obeticholic acidobeticholic acid results in decreased expression of CCS mRNA27939613
C030110oxaliplatinCCS protein affects the susceptibility to oxaliplatin16773204
C030110oxaliplatinoxaliplatin results in increased expression of CCS mRNA16773204
D010100OxygenOxygen deficiency results in decreased expression of CCS protein19351718
D010269ParaquatParaquat affects the expression of CCS mRNA25064622
D010269ParaquatCCS gene mutant form results in increased susceptibility to Paraquat10694572
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CCS protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CCS protein19954255
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of CCS mRNA28659758
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCS mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CCS mRNA17426115|1830175
C010313pseudocumenepseudocumene results in decreased expression of CCS protein17337753
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of CCS mRNA28659758
D012834SilverSilver affects the expression of CCS mRNA19429238
D013311StreptozocinStreptozocin results in decreased expression of CCS mRNA24927960
D013311StreptozocinStreptozocin results in decreased expression of CCS protein24927960
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA]24927960
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]24927960
C004648testosterone enanthatetestosterone enanthate affects the expression of CCS mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCS mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CCS mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CCS mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCS mRNA18796159|1977048
D013752TetracyclineTetracycline affects the expression of CCS mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCS mRNA25613284
C034269tetraethylenepentaminetetraethylenepentamine results in increased expression of CCS protein24343031
C020809tetrathiomolybdatetetrathiomolybdate results in increased expression of CCS protein21784888
D013853ThioacetamideThioacetamide affects the expression of CCS mRNA25064622
C012589trichostatin Atrichostatin A affects the expression of CCS mRNA28542535
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA]24927960
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]24927960
D013721Triethylenephosphoramide[cobaltiprotoporphyrin binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]19039664
D013721TriethylenephosphoramideCopper Sulfate inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]19039664
D013721Triethylenephosphoramide[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]19039664
D013721TriethylenephosphoramideTriethylenephosphoramide results in increased expression of CCS protein19039664
D014635Valproic AcidValproic Acid affects the expression of CCS mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of CCS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CCS gene29154799
D014640VancomycinVancomycin results in increased expression of CCS mRNA18930951
D014810Vitamin EVitamin E results in increased expression of CCS mRNA19244175
D015032ZincZinc binds to CCS protein15736924
D015032Zinc[Copper deficiency co-treated with Zinc] results in increased expression of CCS18820153

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004784superoxide dismutase activity-IBA21873635  
GO:0004784superoxide dismutase activity-IEA-  
GO:0005507copper ion binding-IBA21873635  
GO:0005507copper ion binding-IDA9726962  
GO:0005515protein binding-IPI9726962  20154138  
GO:0008270zinc ion binding-IBA21873635  
GO:0015035protein disulfide oxidoreductase activity-TAS-  
GO:0016532superoxide dismutase copper chaperone activity-IBA21873635  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006801superoxide metabolic process-TAS9295278  
GO:0015680intracellular copper ion transport-TAS9726962  
GO:0019430removal of superoxide radicals-IBA21873635  
GO:0019430removal of superoxide radicals-IEA-  
GO:0034599cellular response to oxidative stress-TAS-  
GO:0051353positive regulation of oxidoreductase activity-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-IDA9726962  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9726962  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26666465Assessment of Subclinical Atherosclerosis Using Computed Tomography Calcium Scores in Patients with Familial and Nonfamilial Hypercholesterolemia. (2016 May 2)Galaska RJ Atheroscler Thromb
28232172Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. (2017 May)Abdul-Muneer PMBrain Behav Immun
28177498Effects of Switching to the Menthol Tobacco Heating System 2.2, Smoking Abstinence, or Continued Cigarette Smoking on Clinically Relevant Risk Markers: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 2). (2018 Jan 5)Ludicke FNicotine Tob Res
27693654Assessment of the reduction in levels of exposure to harmful and potentially harmful constituents in Japanese subjects using a novel tobacco heating system compared with conventional cigarettes and smoking abstinence: A randomized controlled study in confinement. (2016 Nov)Haziza CRegul Toxicol Pharmacol
14975543Cigarette smoking and inflammatory indices in coronary artery disease. (2004 Feb)Mizia-Stec KInt J Cardiol
22855882Assessing tobacco dependence among cannabis users smoking cigarettes. (2013 Feb)Flatz ANicotine Tob Res
27190066Macrophage migration inhibitory factor, a role in COPD. (2016 Jul 1)Husebo GRAm J Physiol Lung Cell Mol Physiol
23866471Is there any benefit of preoperative oral trimetazidine in coronary artery bypass graft? (2012 Dec)Sher-i-Murtaza MJ Pak Med Assoc
28177489Effects of Switching to the Tobacco Heating System 2.2 Menthol, Smoking Abstinence, or Continued Cigarette Smoking on Biomarkers of Exposure: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 1). (2018 Jan 5)Ludicke FNicotine Tob Res
20069434Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk. (2010 Jul)Palma SJ Cancer Res Clin Oncol
25279458Predictors of exacerbations in chronic obstructive pulmonary disease--results from the Bergen COPD cohort study. (2014)Husebo GRPLoS One
9735641Risks of cerebrovascular events related to open heart surgery. (1998 Aug)Attum AAJ Ky Med Assoc