Gene: NR1D2

9975
BD73|EAR-1R|REVERBB|REVERBbeta|RVR
nuclear receptor subfamily 1 group D member 2
protein-coding
3p24.2
Ensembl:ENSG00000174738 MIM:602304 Vega:OTTHUMG00000155659 UniprotKB:Q14995
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.129e-1 (AD)  4.681e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAPEPLD0.933
FAM217B0.929
ARHGAP320.928
COL4A3BP0.924
NPEPPS0.924
DSTYK0.922
ZADH20.919
CAND10.918
GRIA20.918
EFR3A0.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.539
OR4F29-0.509
TFPI2-0.452
CSAG1-0.408
MYL3-0.404
ARHGEF5-0.398
C9orf135-0.397
KLRB1-0.397
MDFI-0.397
KLF17-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NR1D2 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of NR1D2 mRNA"19162173
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NR1D2 mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of NR1D2 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NR1D2 mRNA"27291303
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NR1D2 mRNA"28433925
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of NR1D2 mRNA"20406850
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of NR1D2 mRNA28522335
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NR1D2 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR1D2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR1D2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of NR1D2 mRNA19191707
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of NR1D2 mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR1D2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR1D2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NR1D2 mRNA21420995|2906747
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NR1D2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of NR1D2 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of NR1D2 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of NR1D2 mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NR1D2 mRNA24449571
D001151ArsenicArsenic affects the expression of NR1D2 mRNA18414638
D001151ArsenicArsenic results in decreased expression of NR1D2 mRNA19654921
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NR1D2 mRNA"18687144
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of NR1D2 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D2 mRNA27858113
D001554BenzeneBenzene results in increased expression of NR1D2 mRNA17905399
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NR1D2 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NR1D2 mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of NR1D2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NR1D2 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NR1D2 mRNA20064835
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NR1D2 mRNA]15034205
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NR1D2 mRNA20127859
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NR1D2 mRNA15034205|1977048
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in increased expression of NR1D2 mRNA18192240
C006780bisphenol Abisphenol A results in increased expression of NR1D2 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of NR1D2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of NR1D2 mRNA25594700
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NR1D2 mRNA"28433925
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of NR1D2 mRNA22079614
D002065BuspironeBuspirone results in increased expression of NR1D2 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of NR1D2 mRNA26079696
D002118CalciumCalcium affects the expression of NR1D2 mRNA15913539
D002220CarbamazepineCarbamazepine affects the expression of NR1D2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NR1D2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NR1D2 mRNA12734012
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of NR1D2 mRNA19072826
D002737ChloropreneChloroprene results in increased expression of NR1D2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR1D2 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D2 mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of NR1D2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NR1D2 mRNA]17585979
D003033Coal TarCoal Tar results in decreased expression of NR1D2 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of NR1D2 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NR1D2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of NR1D2 mRNA19549813
C030123coumarincoumarin results in increased expression of NR1D2 mRNA18480146
D016572CyclosporineCyclosporine affects the expression of NR1D2 mRNA21632981
D016572CyclosporineCyclosporine results in increased expression of NR1D2 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NR1D2 mRNA23640034
D013759DronabinolDronabinol results in increased expression of NR1D2 mRNA16597638
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of NR1D2 mRNA16556975
C023614dibenzofurandibenzofuran analog results in increased expression of NR1D2 mRNA20566336
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NR1D2 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of NR1D2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NR1D2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NR1D2 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of NR1D2 mRNA28302478
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NR1D2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of NR1D2 mRNA19467301
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NR1D2 mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NR1D2 mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of NR1D2 mRNA19638242
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NR1D2 mRNA17351261
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NR1D2 mRNA23649840
D005419FlavonoidsFlavonoids results in increased expression of NR1D2 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NR1D2 mRNA28329830
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of NR1D2 mRNA]15016801
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR1D2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of NR1D2 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of NR1D2 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of NR1D2 mRNA22061828
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of NR1D2 mRNA16556975
D005947GlucoseGlucose results in decreased expression of NR1D2 mRNA17178593
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NR1D2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NR1D2 mRNA27392435
C045463leflunomideleflunomide results in increased expression of NR1D2 mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of NR1D2 mRNA26378955
D008627Mercuric ChlorideMercuric Chloride results in increased expression of NR1D2 mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NR1D2 gene20938992
D008752Methylene ChlorideMethylene Chloride results in increased expression of NR1D2 mRNA28392392
C002950methylformamidemethylformamide analog results in increased expression of NR1D2 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of NR1D2 mRNA17040096
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NR1D2 mRNA23649840
C437683motexafin gadoliniummotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of NR1D2 mRNA16357179
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of NR1D2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NR1D2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NR1D2 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of NR1D2 mRNA24136188
D009532NickelNickel results in increased expression of NR1D2 mRNA23195993
C012655nimesulidenimesulide results in increased expression of NR1D2 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of NR1D2 mRNA19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NR1D2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NR1D2 mRNA25729387
D010269ParaquatParaquat results in decreased expression of NR1D2 mRNA21371552
C046012pentanalpentanal results in decreased expression of NR1D2 mRNA26079696
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of NR1D2 mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NR1D2 mRNA17560707
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NR1D2 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NR1D2 mRNA17560707|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NR1D2 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of NR1D2 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of NR1D2 mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of NR1D2 mRNA18445702|2381119
C006253pirinixic acidpirinixic acid results in increased expression of NR1D2 mRNA17426115
D010938Plant OilsPlant Oils results in increased expression of NR1D2 mRNA23370395
D011374ProgesteroneProgesterone affects the expression of NR1D2 mRNA17251523
C005556propionaldehydepropionaldehyde results in decreased expression of NR1D2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of NR1D2 mRNA24780913
C459379SCH 351591SCH 351591 results in increased expression of NR1D2 mRNA20585143
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NR1D2 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of NR1D2 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of NR1D2 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of NR1D2 mRNA19072884
D053260SootSoot results in increased expression of NR1D2 mRNA22461453|2655175
D020058StyreneStyrene results in increased expression of NR1D2 mRNA28951217
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of NR1D2 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of NR1D2 mRNA14699072
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in increased expression of NR1D2 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NR1D2 mRNA20055451
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NR1D2 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NR1D2 mRNA19770486|2157046
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NR1D2 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NR1D2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NR1D2 mRNA15034205|2597527
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of NR1D2 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of NR1D2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NR1D2 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NR1D2 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NR1D2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of NR1D2 mRNA28973375
D014241TrichloroethyleneTrichloroethylene results in increased expression of NR1D2 mRNA17905399
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR1D2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NR1D2 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NR1D2 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of NR1D2 mRNA22378314
C406224valdecoxibvaldecoxib results in increased expression of NR1D2 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NR1D2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NR1D2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NR1D2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of NR1D2 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of NR1D2 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of NR1D2 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NR1D2 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of NR1D2 mRNA19165385
C025643vinclozolinvinclozolin results in decreased expression of NR1D2 mRNA22496781
D015032ZincZinc results in increased expression of NR1D2 mRNA17074742
D019345Zinc Acetatemotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of NR1D2 mRNA16357179
D019287Zinc SulfateZinc Sulfate results in increased expression of NR1D2 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17892483  17996965  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001206transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0003700DNA-binding transcription factor activityCONTRIBUTES_TOIBA21873635  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0004879nuclear receptor activity-TAS7997240  
GO:0005515protein binding-IPI17892483  17996965  23455924  23555304  
GO:0008134transcription factor binding-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006355regulation of transcription, DNA-templated-TAS7997240  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007275multicellular organism development-IBA21873635  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0019216regulation of lipid metabolic process-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0033993response to lipid-IBA21873635  
GO:0042752regulation of circadian rhythm-IBA21873635  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA17892483  17996965  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0048511rhythmic process-IEA-  
GO:0050727regulation of inflammatory response-ISS-  
GO:0055088lipid homeostasis-ISS-  
GO:0097009energy homeostasis-ISS-  
GO:2001014regulation of skeletal muscle cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17892483  17996965  
GO:0005634nucleus-TAS7997240  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One