Gene: CDC42

998
CDC42Hs|G25K|TKS
cell division cycle 42
protein-coding
1p36.12
Ensembl:ENSG00000070831 MIM:116952 Vega:OTTHUMG00000002753 UniprotKB:P60953
NG_047042.1
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.602e-1 (AD)  6.746e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11572548chr1:22401641CDC42Promoter5.896e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB1A0.959
RAB11A0.957
PSMB20.955
PSMA10.955
UBE2D20.953
HNRNPH20.952
RAB140.951
GNL30.949
PSMC20.949
PSMD70.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.753
OR4F29-0.717
MTRNR2L6-0.285
MTRNR2L9-0.275
MTRNR2L10-0.268
FOXJ1-0.26
EVC2-0.24
ZBTB20-0.232
WDR38-0.225
KCNK5-0.221

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02623Aminophosphonic Acid-Guanylate EsterSmall MoleculeExperimentalTarget
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of CDC42 mRNA"23826121
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of CDC42 protein"23628706
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of CDC42 protein"23628706
C4681141-palmitoyl-2-arachidonyl-3-phosphorylcholine1-palmitoyl-2-arachidonyl-3-phosphorylcholine affects the localization of CDC42 protein15472119
C4681141-palmitoyl-2-arachidonyl-3-phosphorylcholine1-palmitoyl-2-arachidonyl-3-phosphorylcholine results in increased activity of CDC42 protein15472119
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CDC42 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CDC42 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of CDC42 protein"25670856
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of CDC42 mRNA26975756
D000082AcetaminophenAcetaminophen results in increased expression of CDC42 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CDC42 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of CDC42 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CDC42 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDC42 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDC42 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CDC42 mRNA24449571
D001151ArsenicArsenic affects the expression of CDC42 mRNA18414638
D001151ArsenicArsenic affects the methylation of CDC42 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of CDC42 mRNA20458559
D001241AspirinAspirin results in decreased expression of CDC42 mRNA14976132
D001280AtrazineAtrazine results in increased expression of CDC42 mRNA22378314
C447119bazedoxifenebazedoxifene results in increased expression of CDC42 mRNA19914376
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDC42 mRNA22209252
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDC42 mRNA20504355|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC42 mRNA"20018196
C033363beta-1,3-glucan"[resveratrol co-treated with beta-1,3-glucan] results in increased expression of CDC42 mRNA"17690738
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CDC42 mRNA19687787
D004958EstradiolEstradiol results in increased expression of CDC42 mRNA19687787
D004958EstradiolEstradiol results in increased expression of CDC42 protein22342969
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of CDC42 protein22342969
C006780bisphenol Abisphenol A affects the expression of CDC42 mRNA21786754
D000069286BortezomibBortezomib results in decreased expression of CDC42 mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CDC42 mRNA15336504
D002104CadmiumCadmium results in decreased expression of CDC42 mRNA21679763
D002104CadmiumCadmium results in decreased expression of CDC42 protein21679763
D002104CadmiumCadmium results in increased oxidation of CDC42 protein24077948
C028031cadmium acetatecadmium acetate affects the expression of CDC42 mRNA16249259
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDC42 mRNA25863597
D019256Cadmium ChlorideCDC42 protein affects the susceptibility to Cadmium Chloride25863597
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDC42 protein15618353
D002118CalciumCalcium promotes the reaction [PAFAH1B1 protein binds to IQGAP1 protein binds to CDC42 protein]16369480
D002273CarcinogensCarcinogens results in increased expression of CDC42 mRNA16316942
C054133casticincasticin results in decreased expression of CDC42 mRNA28444820
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CDC42 mRNA24763279
D002509CephaloridineCephaloridine results in decreased expression of CDC42 mRNA18172885
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC42 mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC42 protein23650126
C031180chrysenechrysene results in decreased expression of CDC42 mRNA26377693
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B results in decreased activity of CDC42 protein11158304
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CDC42 mRNA15467011
D003300CopperMT1 affects the reaction [Copper results in increased expression of CDC42 mRNA]16629173
D003300CopperMT2 affects the reaction [Copper results in increased expression of CDC42 mRNA]16629173
C030973cupric oxidecupric oxide results in decreased expression of CDC42 protein25470785
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CDC42 mRNA17654400
D013759DronabinolDronabinol results in decreased expression of CDC42 mRNA18454173
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDC42 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of CDC42 mRNA29111458
D016190CarboplatinCarboplatin results in decreased expression of CDC42 mRNA18172885
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CDC42 mRNA27514524
D002945CisplatinCisplatin results in increased expression of CDC42 mRNA25450742
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of CDC42 mRNA21858171
D002945CisplatinCisplatin results in decreased expression of CDC42 mRNA18172885
D002945CisplatinCisplatin results in decreased expression of CDC42 protein23628706
D000431EthanolEthanol results in decreased expression of CDC42 protein20133374|2082942
D000431EthanolEthanol results in decreased expression of [CDC42 protein binds to Guanosine Triphosphate]20829428
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDC42 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC42 mRNA17942748
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of CDC42 protein]"24203571
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in decreased expression of CDC42 mRNA22406618
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in increased expression of CDC42 mRNA22406618
C061365flusilazoleflusilazole affects the expression of CDC42 mRNA21195148
D005557FormaldehydeFormaldehyde results in increased expression of CDC42 mRNA23649840
C056933fumonisin B1fumonisin B1 results in increased expression of CDC42 mRNA16221962
D005707Gallic AcidGallic Acid results in decreased expression of CDC42 protein23153558
D005839GentamicinsGentamicins results in increased expression of CDC42 mRNA22061828
D005947GlucoseGlucose results in increased expression of CDC42 mRNA24659233
D005947GlucoseGlucose results in increased expression of CDC42 protein24659233
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of CDC42 mRNA]24659233
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of CDC42 protein]24659233
C010974glyphosateglyphosate results in decreased expression of CDC42 mRNA26302742
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CDC42 mRNA24763279
D006160Guanosine Triphosphateresveratrol promotes the reaction [CDC42 protein binds to Guanosine Triphosphate]15217905
D006160Guanosine TriphosphateRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]16734383
D006160Guanosine Triphosphatezoledronic acid results in increased expression of [CDC42 protein binds to Guanosine Triphosphate]28871336
D006160Guanosine TriphosphateRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]16734383
D006160Guanosine Triphosphatezoledronic acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]16734383
D006160Guanosine TriphosphateEthanol results in decreased expression of [CDC42 protein binds to Guanosine Triphosphate]20829428
D006220HaloperidolHaloperidol results in increased expression of CDC42 mRNA15860345
C409722hexaconazolehexaconazole affects the expression of CDC42 mRNA21195148
D017313FenretinideFenretinide results in increased expression of CDC42 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CDC42 mRNA17183730
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of CDC42 mRNA19376150
C492448ICG 001ICG 001 results in decreased expression of CDC42 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of CDC42 mRNA18299717
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDC42 mRNA16054899
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDC42 mRNA23086925
D007608Kainic AcidKainic Acid results in increased expression of CDC42 mRNA19700661
D007854LeadLead affects the expression of CDC42 mRNA28903495
D007854LeadLead results in decreased expression of CDC42 mRNA19921347
C065536lead titanate zirconate"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of CDC42 protein]"24203571
C065536lead titanate zirconatelead titanate zirconate results in decreased expression of CDC42 protein24203571
D001556LindaneLindane results in decreased expression of CDC42 mRNA17785943
D008148LovastatinLovastatin results in increased expression of CDC42 protein18766339
D008148LovastatinLovastatin results in decreased expression of CDC42 mRNA20493250
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of CDC42 protein22223485
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CDC42 protein22223485
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of CDC42 mRNA20020106
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of CDC42 protein19000711|2322056
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CDC42 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDC42 mRNA24810058
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA]"20230807
C008493methylselenic acidmethylselenic acid results in decreased expression of CDC42 mRNA11830524
D008777MethyltestosteroneMethyltestosterone results in increased expression of CDC42 mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CDC42 mRNA20024957
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDC42 mRNA"23634900
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA]"20230807
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of CDC42 mRNA17616710
C487513NSC 23766NSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]22166487
D010416PentachlorophenolPentachlorophenol results in increased expression of CDC42 mRNA23892564
D026023Permethrin[fluoranthene co-treated with Permethrin] results in decreased expression of CDC42 mRNA22406618
D026023Permethrin[fluoranthene co-treated with Permethrin] results in increased expression of CDC42 mRNA22406618
D026023PermethrinPermethrin results in decreased expression of CDC42 mRNA22406618
D026023PermethrinPermethrin results in increased expression of CDC42 mRNA22406618
D010634PhenobarbitalPhenobarbital results in increased expression of CDC42 mRNA19363144
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of CDC42 mRNA21858171
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of CDC42 mRNA20020106
D059808PolyphenolsPolyphenols results in decreased expression of CDC42 protein22279137
D059808Polyphenols[Polyphenols results in decreased expression of CDC42 protein] which results in increased expression of VHL protein22279137
D059808Polyphenols[[Polyphenols results in decreased expression of CDC42 protein] which results in increased expression of VHL protein] which results in increased degradation of HIF1A protein22279137
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CDC42 mRNA19687787
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of CDC42 protein22342969
D011374ProgesteroneProgesterone results in increased expression of CDC42 protein22342969
C015586propiverinepropiverine binds to CDC42 protein29273565
D011429PropolisPropolis results in decreased expression of CDC42 protein22279137
D011429Propolis[Propolis results in decreased expression of CDC42 protein] which results in increased expression of VHL protein22279137
D011429Propolis[[Propolis results in decreased expression of CDC42 protein] which results in increased expression of VHL protein] which results in increased degradation of HIF1A protein22279137
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CDC42 mRNA27514524
C059514resveratrolresveratrol promotes the reaction [CDC42 protein binds to Guanosine Triphosphate]15217905
C059514resveratrolresveratrol results in increased activity of and affects the localization of CDC42 protein15217905
C059514resveratrol"[resveratrol co-treated with beta-1,3-glucan] results in increased expression of CDC42 mRNA"17690738
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of CDC42 mRNA]24659233
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of CDC42 protein]24659233
C059514resveratrolCDC42 protein affects the susceptibility to resveratrol15217905
C059514resveratrolCDC42 protein mutant form inhibits the reaction [resveratrol results in increased expression of FASLG]15217905
C059514resveratrolCDC42 protein mutant form results in decreased susceptibility to resveratrol15217905
D000068296Risedronate SodiumRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]16734383
D000068296Risedronate SodiumRisedronate Sodium results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]16734383
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDC42 mRNA16054899
D012402RotenoneRotenone results in decreased activity of CDC42 protein18480073
D012402RotenoneRotenone results in decreased expression of CDC42 protein22223485
C508970secramine Asecramine A results in decreased activity of CDC42 protein19430526
D012715Sesame OilSesame Oil results in decreased expression of CDC42 mRNA29191790
D019821SimvastatinSimvastatin results in decreased activity of CDC42 protein17169357
C080703SK&F 83959SK&F 83959 results in decreased expression of CDC42 protein25852303
C017947sodium arsenitesodium arsenite results in decreased expression of CDC42 protein19072884
C016104sodium bichromatesodium bichromate results in increased expression of CDC42 mRNA12325037
D018038Sodium SeleniteSodium Selenite results in increased expression of CDC42 mRNA18175754
D013629TamoxifenTamoxifen affects the expression of CDC42 mRNA17555576
D013739TestosteroneTestosterone results in increased expression of CDC42 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDC42 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC42 mRNA17942748
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of CDC42 protein"25852303
C009495titanium dioxidetitanium dioxide results in decreased expression of CDC42 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CDC42 mRNA28065790
C036454toosendanintoosendanin results in decreased expression of CDC42 protein23111283
C005846tremolitetremolite results in decreased expression of CDC42 protein22578742
D014212TretinoinTretinoin results in decreased expression of CDC42 mRNA23724009
C032910triadimefontriadimefon affects the expression of CDC42 mRNA21195148
C001899triptolidetriptolide results in decreased expression of CDC42 mRNA27554044
C001899triptolidetriptolide results in decreased expression of CDC42 protein27554044
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDC42 mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CDC42 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of CDC42 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CDC42 gene25560391
D014859WarfarinWarfarin results in decreased expression of CDC42 mRNA20493250
D014873Water PollutantsWater Pollutants results in decreased expression of CDC42 mRNA23591932
C016837zinc chloridezinc chloride results in increased expression of CDC42 mRNA16973896
D015034Zinc OxideNSC 23766 inhibits the reaction [Zinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]]22166487
D015034Zinc Oxide[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein]22166487
D015034Zinc OxideZinc Oxide results in increased activity of and results in increased phosphorylation of [RAC1 protein binds to CDC42 protein]22166487
C088658zoledronic acidzoledronic acid results in increased expression of and affects the localization of CDC42 protein28871336
C088658zoledronic acidzoledronic acid results in increased expression of [CDC42 protein binds to Guanosine Triphosphate]28871336
C088658zoledronic acidzoledronic acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]16734383

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IDA19787194  
GO:0003924GTPase activity-TAS11035016  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI7493928  7512369  7629060  7738010  7744004  8034624  
8107774  8625410  8670801  8702968  8798539  9082982  
9418861  9422512  9660763  10051605  10587647  10713100  
10816584  10934474  11035016  11090627  11260256  11807099  
12093730  12456510  12606577  12745076  12879077  14676191  
15194684  15361624  15728724  15834156  16189514  16293614  
16443932  16968699  17145773  17353931  19171758  19596003  
19798448  20890305  20936779  21029865  21048939  21167153  
21311754  21435037  21454543  21566117  21900206  21988832  
22653441  23022564  23175184  23455922  24076653  25074804  
25241761  25284480  25416956  26496610  28028151  
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-IDA8625410  15601624  23620790  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IDA19039103  
GO:0019901protein kinase binding-IPI8625410  20873783  21048939  
GO:0031996thioesterase binding-IPI12612085  
GO:0032427GBD domain binding-IPI8625410  10724160  
GO:0034191apolipoprotein A-I receptor binding-IPI16443932  
GO:0042802identical protein binding-IPI9748241  
GO:0061630ubiquitin protein ligase activity-IDA21435037  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0006897endocytosis-IBA21873635  
GO:0006911phagocytosis, engulfment-IMP26465210  
GO:0007015actin filament organization-IBA21873635  
GO:0007015actin filament organization-IMP26465210  
GO:0007030Golgi organization-ISS-  
GO:0007163establishment or maintenance of cell polarity-IBA21873635  
GO:0007163establishment or maintenance of cell polarity-TAS11260256  
GO:0007229integrin-mediated signaling pathway-IMP26051942  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0007596blood coagulation-TAS-  
GO:0008360regulation of cell shape-IBA21873635  
GO:0010591regulation of lamellipodium assembly-IGI8625410  
GO:0010592positive regulation of lamellipodium assembly-IMP8625410  
GO:0016477cell migration-IBA21873635  
GO:0016567protein ubiquitination-IEA-  
GO:0021762substantia nigra development-HEP22926577  
GO:0030031cell projection assembly-IBA21873635  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0030036actin cytoskeleton organization-IDA11035016  
GO:0030225macrophage differentiation-TAS11260256  
GO:0030307positive regulation of cell growth-IMP21435037  
GO:0030865cortical cytoskeleton organization-IBA21873635  
GO:0031274positive regulation of pseudopodium assembly-IDA11035016  
GO:0031295T cell costimulation-TAS-  
GO:0031333negative regulation of protein complex assembly-IPI11584266  
GO:0032467positive regulation of cytokinesis-IMP15642749  
GO:0032488Cdc42 protein signal transduction-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0034329cell junction assembly-IMP22891260  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0038189neuropilin signaling pathway-IMP26051942  
GO:0039694viral RNA genome replication-IMP19376974  
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway-TAS-  
GO:0045198establishment of epithelial cell apical/basal polarity-IMP22891260  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0051149positive regulation of muscle cell differentiation-TAS-  
GO:0051489regulation of filopodium assembly-IDA14978216  
GO:0051491positive regulation of filopodium assembly-IMP26051942  
GO:0051491positive regulation of filopodium assembly-ISS-  
GO:0051492regulation of stress fiber assembly-IGI8625410  
GO:0051496positive regulation of stress fiber assembly-IMP8625410  26051942  
GO:0051683establishment of Golgi localization-ISS-  
GO:0051988regulation of attachment of spindle microtubules to kinetochore-IMP15642749  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO:0060997dendritic spine morphogenesis-ISS-  
GO:0072384organelle transport along microtubule-ISS-  
GO:0099563modification of synaptic structure-IBA21873635  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-IDA11807099  
GO:2000251positive regulation of actin cytoskeleton reorganization-IMP26051942  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA11260256  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005813centrosomecolocalizes_withIDA20873783  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA11260256  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005938cell cortex-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IDA11807099  
GO:0017119Golgi transport complex-IMP16380373  
GO:0030175filopodium-IDA11035016  
GO:0030496midbody-IDA15642749  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0031982vesicle-IBA21873635  
GO:0032991protein-containing complex-IDA20873783  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA15121898  
GO:0042995cell projection-IBA21873635  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-IDA21048939  
GO:0043025neuronal cell body-IDA21048939  
GO:0043197dendritic spine-IBA21873635  
GO:0043197dendritic spine-IDA24352656  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0051233spindle midzone-IDA15642749  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
GO:0072686mitotic spindle-IDA15642749  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa04660T cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04912GnRH signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114604GPVI-mediated activation cascadeTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-177929Signaling by EGFRTAS
R-HSA-182971EGFR downregulationTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-194840Rho GTPase cycleTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisIEA
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationIEA
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373752Netrin-1 signalingTAS
R-HSA-375170CDO in myogenesisTAS
R-HSA-375170CDO in myogenesisIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389359CD28 dependent Vav1 pathwayTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-418885DCC mediated attractive signalingTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-428543Inactivation of CDC42 and RAC1IEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-525793MyogenesisTAS
R-HSA-525793MyogenesisIEA
R-HSA-5625970RHO GTPases activate KTN1TAS
R-HSA-5626467RHO GTPases activate IQGAPsTAS
R-HSA-5627123RHO GTPases activate PAKsTAS
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsTAS
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsIEA
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-5663220RHO GTPases Activate ForminsIEA
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9020591Interleukin-12 signalingTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22295116Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. (2012)Pei YFPLoS One
28816646Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. (2017 Aug)Solanki HSOMICS
27998433[Effects of mTOR-Cdc42 signaling pathway on phagocytosis of alveolar macrophages in chronic obstructive pulmonary disease mice]. (2016 Dec 13)Wang YJZhonghua Yi Xue Za Zhi
26366560RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin. (2015)Ojelade SAPLoS One
24107512The alpha4 nicotinic receptor promotes CD4+ T-cell proliferation and a helper T-cell immune response. (2014 Jan)Nordman JCMol Pharmacol