Gene: DOPEY2

9980
21orf5|C21orf5
dopey family member 2
protein-coding
21q22.12
Ensembl:ENSG00000142197 MIM:604803 Vega:OTTHUMG00000086619 UniprotKB:Q9Y3R5
NC_000021.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.160e-1 (AD)  9.911e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2284642chr21:36279015 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DMXL20.935
GPRASP10.934
RNMT0.933
FOCAD0.93
DEPDC50.929
HERC10.924
COG10.921
AVL90.92
POLR3A0.92
RASAL20.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.491
HEY2-0.483
YES1-0.469
AKR1C3-0.466
ROM1-0.464
CSAG1-0.456
MTRNR2L6-0.455
MTRNR2L9-0.454
COPZ2-0.454
MYL3-0.453

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DOPEY2 mRNA"27291303
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DOPEY2 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of DOPEY2 mRNA22230336|2906747
C015001arsenitearsenite results in decreased methylation of DOPEY2 promoter23974009
D001280AtrazineAtrazine results in decreased expression of DOPEY2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of DOPEY2 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOPEY2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DOPEY2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOPEY2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DOPEY2 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of DOPEY2 mRNA19167446
C006780bisphenol Abisphenol A results in increased expression of DOPEY2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DOPEY2 gene28505145
C584509C646 compoundC646 compound results in increased expression of DOPEY2 mRNA26191083
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DOPEY2 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DOPEY2 mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of DOPEY2 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of DOPEY2 mRNA19167446
C029892cupric chloridecupric chloride results in decreased expression of DOPEY2 mRNA19174923
D016572CyclosporineCyclosporine results in increased expression of DOPEY2 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DOPEY2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of DOPEY2 mRNA27392435|2759478
D004147DioxinsDioxins affects the expression of DOPEY2 mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DOPEY2 mRNA22079256
D000431EthanolEthanol results in increased expression of DOPEY2 mRNA19167417
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DOPEY2 mRNA21179406
C492448ICG 001ICG 001 results in increased expression of DOPEY2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DOPEY2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of DOPEY2 mRNA21889194|2479639
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of DOPEY2 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DOPEY2 mRNA23649840
C059539midostaurinmidostaurin results in increased expression of DOPEY2 mRNA20980353
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of DOPEY2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DOPEY2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DOPEY2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DOPEY2 mRNA"25620056
D010100OxygenOxygen deficiency affects the methylation of DOPEY2 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of DOPEY2 mRNA24205000
C016030pantogabpantogab results in increased expression of DOPEY2 mRNA17379144
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DOPEY2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of DOPEY2 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DOPEY2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DOPEY2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DOPEY2 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of DOPEY2 mRNA28903501
C045950propiconazolepropiconazole results in increased expression of DOPEY2 mRNA21278054
D015474IsotretinoinIsotretinoin results in decreased expression of DOPEY2 mRNA20436886
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DOPEY2 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DOPEY2 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DOPEY2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DOPEY2 mRNA29024780
D014520UrethaneUrethane results in increased expression of DOPEY2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DOPEY2 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of DOPEY2 mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of DOPEY2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006895Golgi to endosome transport-IBA21873635  
GO:0006895Golgi to endosome transport-ISS16301316  
GO:0007029endoplasmic reticulum organization-ISS16301316  
GO:0007275multicellular organism development-NAS10950924  
GO:0015031protein transport-IEA-  
GO:0050890cognition-IMP23227193  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-ISS16301316  
GO:0005768endosome-IBA21873635  
GO:0005802trans-Golgi network-IBA21873635  
GO:0005829cytosol-IEA-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal