Gene: FGFBP1

9982
FGF-BP|FGF-BP1|FGFBP|FGFBP-1|HBP17
fibroblast growth factor binding protein 1
protein-coding
4p15.32
Ensembl:ENSG00000137440 MIM:607737 Vega:OTTHUMG00000097745 UniprotKB:Q14512
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.672e-1 (AD)  2.311e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPINK50.831
SERPINB30.83
ADH70.828
KRT150.803
MUC210.78
DAZ10.747
TMPRSS11B0.744
SPRR2D0.74
KRT6B0.73
IVL0.726

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRR16-0.184
TP53TG3D-0.177
ZNRF4-0.172
POMZP3-0.169
CRYGA-0.166
C16orf87-0.166
PCDHB10-0.166
FAM91A1-0.163
INGX-0.162
SIAH1-0.162

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FGFBP1 mRNA"23146750
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of FGFBP1 mRNA"24172598
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of FGFBP1 mRNA16788091
D020106AcrylamideAcrylamide results in increased expression of FGFBP1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FGFBP1 mRNA22100608
D000393Air PollutantsAir Pollutants analog results in increased expression of FGFBP1 mRNA21757418
D000447AldehydesAldehydes results in increased expression of FGFBP1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGFBP1 mRNA16483693
D001151ArsenicArsenic affects the methylation of FGFBP1 gene25304211
C015001arsenitearsenite results in increased expression of FGFBP1 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of FGFBP1 mRNA]18929588
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FGFBP1 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of FGFBP1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of FGFBP1 mRNA26079696
D002211CapsaicinCapsaicin affects the expression of FGFBP1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]22150557
C100187chloropicrinchloropicrin results in decreased expression of FGFBP1 mRNA26352163|2847649
D002737ChloropreneChloroprene results in increased expression of FGFBP1 mRNA23125180
D016572CyclosporineCyclosporine results in decreased expression of FGFBP1 mRNA22147139
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of FGFBP1 mRNA20705681
D004041Dietary FatsDietary Fats results in increased expression of FGFBP1 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FGFBP1 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of FGFBP1 mRNA15171707
D002117CalcitriolCalcitriol results in decreased expression of FGFBP1 mRNA16002434
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of FGFBP1 mRNA23876855
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of FGFBP1 mRNA"27840820
D004237DiuronDiuron metabolite results in decreased expression of FGFBP1 mRNA24172598
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FGFBP1 mRNA17351261
D005419FlavonoidsFlavonoids results in decreased expression of FGFBP1 mRNA18035473
C039281furanfuran results in increased expression of FGFBP1 mRNA27387713
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FGFBP1 mRNA20044591
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FGFBP1 mRNA26752646
D008345ManganeseManganese results in decreased expression of FGFBP1 mRNA26745496
C025340manganese chloridemanganese chloride results in decreased expression of FGFBP1 mRNA26745496
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of FGFBP1 mRNA23876855
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of FGFBP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FGFBP1 mRNA"25554681
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]22150557
D009532NickelNickel results in increased expression of FGFBP1 mRNA25583101
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of FGFBP1 mRNA17616710
D010126OzoneOzone results in increased expression of FGFBP1 mRNA17095637
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of FGFBP1 mRNA20705681
D000073878Palm OilPalm Oil results in increased expression of FGFBP1 mRNA18042831
C046012pentanalpentanal results in increased expression of FGFBP1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of FGFBP1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of FGFBP1 mRNA22237054
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FGFBP1 mRNA23146750
C006253pirinixic acidpirinixic acid results in increased expression of FGFBP1 mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of FGFBP1 mRNA18037150
C005556propionaldehydepropionaldehyde results in increased expression of FGFBP1 mRNA26079696
C078903seocalcitolseocalcitol results in decreased expression of FGFBP1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FGFBP1 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of FGFBP1 mRNA23876855
C017947sodium arsenitesodium arsenite results in increased expression of FGFBP1 mRNA28595984
D053260SootSoot results in increased expression of FGFBP1 mRNA26551751
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]22150557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FGFBP1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGFBP1 mRNA17035482|1977048
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in increased expression of FGFBP1 mRNA26854739
C009495titanium dioxidetitanium dioxide results in increased expression of FGFBP1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FGFBP1 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of FGFBP1 mRNA16788091
D014639VanadiumVanadium results in decreased expression of FGFBP1 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FGFBP1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FGFBP1 mRNA23034163|2386920
C029297vinylidene chloridevinylidene chloride results in decreased expression of FGFBP1 mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of FGFBP1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16257968  
GO:0008201heparin binding-TAS1885605  
GO:0017134fibroblast growth factor binding-IEA-  
GO:0019838growth factor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS1885605  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007267cell-cell signaling-TAS1885605  
GO:0008285negative regulation of cell proliferation-TAS1885605  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS-  
GO:0045743positive regulation of fibroblast growth factor receptor signaling pathway-IEA-  
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis-IDA27121396  
GO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IDA27121396  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0009986cell surface-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190241FGFR2 ligand binding and activationTAS
R-HSA-190377FGFR2b ligand binding and activationTAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22074045The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate. (2013 Jan)Wang HCleft Palate Craniofac J