Gene: SLC12A6

9990
ACCPN|KCC3|KCC3A|KCC3B
solute carrier family 12 member 6
protein-coding
15q14
Ensembl:ENSG00000140199 MIM:604878 Vega:OTTHUMG00000129441 UniprotKB:Q9UHW9
NG_007951.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.071e-1 (AD)  4.179e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE4A0.951
FTO0.935
LNPEP0.933
SMCR80.924
USP320.923
NEU30.92
PLEKHM30.916
TRIQK0.912
DDX60.91
FBXO110.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.464
BCL7C-0.455
PPP1R14B-0.418
S100A14-0.413
HMX1-0.41
RBP1-0.406
RARRES2-0.403
RAB13-0.394
ROM1-0.386
VAX2-0.38

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00761Potassium ChlorideSmall Molecule7447-40-7Approved|WithdrawnTransporter
DB00761Potassium ChlorideSmall Molecule7447-40-7Approved|WithdrawnTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC12A6 mRNA19933214
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC12A6 mRNA]"19467301
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of SLC12A6 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC12A6 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC12A6 gene27153756
D001280AtrazineAtrazine results in decreased expression of SLC12A6 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC12A6 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of SLC12A6 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SLC12A6 mRNA25181051
D001965BromidesSLC12A6 protein results in increased transport of Bromides11443066
D002034BumetanideBumetanide results in decreased activity of SLC12A6 protein11443066
C059041calyculin Acalyculin A results in decreased activity of SLC12A6 protein11443066
D002712ChloridesSLC12A6 protein results in increased transport of Chlorides11443066
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC12A6 mRNA23650126
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SLC12A6 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of SLC12A6 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of SLC12A6 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SLC12A6 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SLC12A6 mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC12A6 mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC12A6 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SLC12A6 mRNA19467301
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of SLC12A6 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SLC12A6 mRNA17547211
D005033EthylmaleimideEthylmaleimide results in increased activity of SLC12A6 protein11443066
C069837fullerene C60fullerene C60 results in decreased expression of SLC12A6 mRNA19167457
D005665FurosemideFurosemide results in decreased activity of SLC12A6 protein11443066
D005839GentamicinsGentamicins results in increased expression of SLC12A6 mRNA22061828
C030691gluconic acidSLC12A6 protein results in increased transport of gluconic acid11443066
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SLC12A6 mRNA21889194|2479639
D008627Mercuric ChlorideMercuric Chloride results in increased activity of SLC12A6 protein11443066
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC12A6 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC12A6 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC12A6 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC12A6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC12A6 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of SLC12A6 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SLC12A6 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of SLC12A6 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC12A6 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SLC12A6 protein26879310
D019800PhenolPhenol results in increased expression of SLC12A6 mRNA17547211
D010710PhosphatesSLC12A6 protein results in increased transport of Phosphates11443066
D010936Plant ExtractsPlant Extracts results in increased expression of SLC12A6 mRNA23557933
D011188PotassiumSLC12A6 protein results in increased transport of Potassium11443066
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLC12A6 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC12A6 mRNA24780913
D012413RubidiumSLC12A6 protein results in increased uptake of Rubidium11443066
C009277sodium arsenatesodium arsenate results in increased expression of SLC12A6 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC12A6 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC12A6 mRNA19770486|1993321
D013792ThalidomideSLC12A6 gene SNP results in increased susceptibility to Thalidomide21245421
C031760thiocyanateSLC12A6 protein results in increased transport of thiocyanate11443066
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC12A6 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SLC12A6 mRNA25729387
D014520UrethaneUrethane results in increased expression of SLC12A6 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015379potassium:chloride symporter activity-IBA21873635  
GO:0015379potassium:chloride symporter activity-IDA10187864  16048901  
GO:0015379potassium:chloride symporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-NAS10187864  
GO:0006811ion transport-IDA10187864  
GO:0006811ion transport-TAS-  
GO:0006884cell volume homeostasis-IBA21873635  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0010107potassium ion import-IBA21873635  
GO:0055064chloride ion homeostasis-IBA21873635  
GO:0055075potassium ion homeostasis-IBA21873635  
GO:0071477cellular hypotonic salinity response-IDA16048901  
GO:0071805potassium ion transmembrane transport-IEA-  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0016021integral component of membrane-NAS10187864  
GO:0016323basolateral plasma membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-426117Cation-coupled Chloride cotransportersTAS
R-HSA-5619039Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29551738Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus. (2018 Mar 15)Dong JClin Gastroenterol Hepatol