Gene: SCO2

9997
CEMCOX1|MYP6|SCO1L
SCO2, cytochrome c oxidase assembly protein
protein-coding
22q13.33
Ensembl:ENSG00000284194 MIM:604272 Vega:OTTHUMG00000191637 UniprotKB:O43819
NG_016235.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.288e-1 (AD)  8.483e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRCC0.889
USF10.885
ATP6V0B0.885
RAB240.882
NAPA0.882
ATG4B0.878
CORO1A0.876
SCYL10.874
AP2S10.873
NUP620.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.631
OR4F29-0.572
ASB4-0.345
MYOM1-0.325
MBNL3-0.318
PARD3B-0.317
LRAT-0.311
C5orf64-0.302
KIAA0754-0.289
TRPV5-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SCO2 mRNA"20453058
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of SCO2 mRNA"19561079
D000082AcetaminophenAcetaminophen results in decreased expression of SCO2 mRNA25704631
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SCO2 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of SCO2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SCO2 mRNA15034205
D001629BezafibrateBezafibrate results in increased activity of SCO2 protein mutant form22515166
D001629Bezafibratecupric chloride promotes the reaction [Bezafibrate results in increased activity of SCO2 protein mutant form]22515166
D003300CopperSCO2 gene mutant form results in decreased abundance of Copper21563821
D003300Copper[SCO2 protein affects the oxidation of SCO1 protein] which affects the abundance of Copper23345593
D019327Copper SulfateCopper Sulfate results in decreased expression of SCO2 mRNA19549813
C029892cupric chloridecupric chloride promotes the reaction [Bezafibrate results in increased activity of SCO2 protein mutant form]22515166
D016572CyclosporineCyclosporine results in decreased expression of SCO2 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SCO2 mRNA]27941970
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SCO2 mRNA23649840
D017313FenretinideFenretinide results in increased expression of SCO2 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SCO2 protein18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SCO2 mRNA23086925
D048628KetolidesKetolides analog results in decreased expression of SCO2 mRNA24967691
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SCO2 mRNA23649840
D009532NickelNickel results in increased expression of SCO2 mRNA25583101
D010656PhenylephrinePhenylephrine results in decreased expression of SCO2 protein25107896
D010656PhenylephrineVEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein]25107896
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of SCO2 protein27634759
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of SCO2 mRNA21042727
D017382Reactive Oxygen SpeciesTP53 protein promotes the reaction [Reactive Oxygen Species results in increased expression of SCO2 mRNA]21042727
D012643SeleniumSelenium results in increased expression of SCO2 mRNA19244175
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of SCO2 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCO2 mRNA15034205|2892240
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SCO2 protein18951874
D014520UrethaneUrethane results in decreased expression of SCO2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of SCO2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of SCO2 gene29154799
D014750VincristineVincristine results in decreased expression of SCO2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005507copper ion binding-NAS10545952  
GO:0005515protein binding-IPI24403053  25959673  28330871  29154948  29381136  
GO:0015035protein disulfide oxidoreductase activity-IDA19336478  
GO ID GO Term Qualifier Evidence PubMed
GO:0001654eye development-IMP23643385  
GO:0006825copper ion transport-IEA-  
GO:0006878cellular copper ion homeostasis-IEA-  
GO:0033617mitochondrial respiratory chain complex IV assembly-IMP15229189  
GO:0045454cell redox homeostasis-IEA-  
GO:0055114oxidation-reduction process-TAS10545952  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-TAS10545952  
GO:0005759mitochondrial matrix-TAS-  
GO:0030016myofibril-IDA20864674  
GO:0031305integral component of mitochondrial inner membrane-IDA15229189  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29634976High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma. (2018 Apr 7)Liu JHum Pathol
3662082Accuracy of response of six pulse oximeters to profound hypoxia. (1987 Oct)Severinghaus JWAnesthesiology