rs10063505

Organism: Homo sapiens

Alleles: C>A

Gene : Feature

MYO10 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C==0113 (3354/29648,GnomAD)
C==0155 (4527/29118,TOPMED)
C==0138 (693/5008,1000G)
C==0040 (156/3854,ALSPAC)
C==0039 (145/3708,TWINSUK)

Position: chr5:16822062 (GRCh38.p7) (5p15.1)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 77 Enhancers around

Promoter: 16 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 5	NC_000005.10:g.16822062C>A
GRCh37.p13 chr 5	NC_000005.9:g.16822171C>A

Gene: MYO10, myosin X(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
MYO10 transcript	NM_012334.2:c.	N/A	Intron Variant
MYO10 transcript variant X1	XM_006714475.2:c.	N/A	Intron Variant
MYO10 transcript variant X2	XM_005248306.4:c.	N/A	Genic Upstream Transcript Variant
MYO10 transcript variant X4	XM_005248307.2:c.	N/A	Genic Upstream Transcript Variant
MYO10 transcript variant X3	XM_011514046.2:c.	N/A	Genic Upstream Transcript Variant

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.352	A=0.648
1000Genomes	American	Sub	694	C=0.160	A=0.840
1000Genomes	East Asian	Sub	1008	C=0.040	A=0.960
1000Genomes	Europe	Sub	1006	C=0.042	A=0.958
1000Genomes	Global	Study-wide	5008	C=0.138	A=0.862
1000Genomes	South Asian	Sub	978	C=0.030	A=0.970
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.040	A=0.960
The Genome Aggregation Database	African	Sub	8630	C=0.286	A=0.714
The Genome Aggregation Database	American	Sub	834	C=0.150	A=0.850
The Genome Aggregation Database	East Asian	Sub	1620	C=0.036	A=0.964
The Genome Aggregation Database	Europe	Sub	18262	C=0.037	A=0.962
The Genome Aggregation Database	Global	Study-wide	29648	C=0.113	A=0.886
The Genome Aggregation Database	Other	Sub	302	C=0.090	A=0.910
Trans-Omics for Precision Medicine	Global	Study-wide	29118	C=0.155	A=0.844
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.039	A=0.961

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs10063505	0.000886	alcohol dependence	20201924

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr5	16785331	16785524	E067	-36647
chr5	16809338	16810567	E067	-11604
chr5	16774222	16774413	E070	-47758
chr5	16780471	16780681	E070	-41490
chr5	16791913	16792024	E070	-30147
chr5	16792096	16792222	E070	-29949
chr5	16792263	16792336	E070	-29835
chr5	16792359	16792450	E070	-29721
chr5	16792455	16792696	E070	-29475
chr5	16792737	16793347	E070	-28824
chr5	16809338	16810567	E070	-11604
chr5	16855311	16855524	E070	33140
chr5	16855631	16856123	E070	33460
chr5	16785331	16785524	E071	-36647
chr5	16791222	16791858	E071	-30313
chr5	16809338	16810567	E071	-11604
chr5	16835998	16836587	E071	13827
chr5	16836758	16836808	E071	14587
chr5	16841361	16841691	E071	19190
chr5	16784948	16784998	E072	-37173
chr5	16785331	16785524	E072	-36647
chr5	16785331	16785524	E073	-36647
chr5	16808264	16808457	E073	-13714
chr5	16809136	16809322	E073	-12849
chr5	16809338	16810567	E073	-11604
chr5	16841361	16841691	E074	19190
chr5	16841733	16842023	E074	19562
chr5	16855631	16856123	E074	33460
chr5	16782379	16782456	E081	-39715
chr5	16783084	16783134	E081	-39037
chr5	16784948	16784998	E081	-37173
chr5	16785331	16785524	E081	-36647
chr5	16791222	16791858	E081	-30313
chr5	16791913	16792024	E081	-30147
chr5	16792096	16792222	E081	-29949
chr5	16792263	16792336	E081	-29835
chr5	16792359	16792450	E081	-29721
chr5	16792455	16792696	E081	-29475
chr5	16792737	16793347	E081	-28824
chr5	16794122	16794176	E081	-27995
chr5	16794375	16794770	E081	-27401
chr5	16800025	16800189	E081	-21982
chr5	16801364	16801423	E081	-20748
chr5	16801521	16801943	E081	-20228
chr5	16806784	16808043	E081	-14128
chr5	16809136	16809322	E081	-12849
chr5	16809338	16810567	E081	-11604
chr5	16810779	16810839	E081	-11332
chr5	16819406	16820060	E081	-2111
chr5	16820264	16820464	E081	-1707
chr5	16838802	16839049	E081	16631
chr5	16842774	16842844	E081	20603
chr5	16842904	16843065	E081	20733
chr5	16843066	16843411	E081	20895
chr5	16843598	16843642	E081	21427
chr5	16857844	16858042	E081	35673
chr5	16858071	16858217	E081	35900
chr5	16864347	16864441	E081	42176
chr5	16864647	16865280	E081	42476
chr5	16865320	16865535	E081	43149
chr5	16791222	16791858	E082	-30313
chr5	16791913	16792024	E082	-30147
chr5	16792096	16792222	E082	-29949
chr5	16792263	16792336	E082	-29835
chr5	16792359	16792450	E082	-29721
chr5	16792455	16792696	E082	-29475
chr5	16792737	16793347	E082	-28824
chr5	16794375	16794770	E082	-27401
chr5	16806784	16808043	E082	-14128
chr5	16809136	16809322	E082	-12849
chr5	16809338	16810567	E082	-11604
chr5	16819406	16820060	E082	-2111
chr5	16838802	16839049	E082	16631
chr5	16864647	16865280	E082	42476
chr5	16865320	16865535	E082	43149
chr5	16866548	16866876	E082	44377
chr5	16866941	16867580	E082	44770

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr5	16826529	16826787	E067	4358
chr5	16826964	16827086	E067	4793
chr5	16827188	16827268	E067	5017
chr5	16826529	16826787	E068	4358
chr5	16826964	16827086	E068	4793
chr5	16826964	16827086	E069	4793
chr5	16827188	16827268	E069	5017
chr5	16826529	16826787	E072	4358
chr5	16826964	16827086	E072	4793
chr5	16827188	16827268	E072	5017
chr5	16826964	16827086	E073	4793
chr5	16827188	16827268	E073	5017
chr5	16826964	16827086	E081	4793
chr5	16826529	16826787	E082	4358
chr5	16826964	16827086	E082	4793
chr5	16827188	16827268	E082	5017

rs10063505

Genomic Coordinates

Gene: MYO10, myosin X(minus strand)

Population Frequency

P-Value

eQTL of rs10063505 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs10063505 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)

Promoter Annotation (GRCh37.p13)