rs10070699

Homo sapiens
G>A
TRPC7 : Intron Variant
TRPC7-AS2 : 500B Downstream Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0324 (9698/29928,GnomAD)
G==0278 (8098/29118,TOPMED)
G==0313 (1569/5008,1000G)
G==0365 (1407/3854,ALSPAC)
G==0359 (1333/3708,TWINSUK)
chr5:136316252 (GRCh38.p7) (5q31.1)
ND
GWASdb2
1   publication(s)
See rs on genome
1 Enhancer around
3 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.136316252G>A
GRCh37.p13 chr 5NC_000005.9:g.135651940G>A

Gene: TRPC7, transient receptor potential cation channel subfamily C member 7(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TRPC7 transcript variant 3NM_001167576.1:c.N/AIntron Variant
TRPC7 transcript variant 2NM_001167577.1:c.N/AIntron Variant
TRPC7 transcript variant 1NM_020389.2:c.N/AIntron Variant

Gene: TRPC7-AS2, TRPC7 antisense RNA 2(plus strand): 500B Downstream Variant

Molecule type Change Amino acid[Codon] SO Term
TRPC7-AS2 transcriptNR_133682.1:n.N/ADownstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.215A=0.785
1000GenomesAmericanSub694G=0.220A=0.780
1000GenomesEast AsianSub1008G=0.271A=0.729
1000GenomesEuropeSub1006G=0.343A=0.657
1000GenomesGlobalStudy-wide5008G=0.313A=0.687
1000GenomesSouth AsianSub978G=0.520A=0.480
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.365A=0.635
The Genome Aggregation DatabaseAfricanSub8712G=0.232A=0.768
The Genome Aggregation DatabaseAmericanSub838G=0.260A=0.740
The Genome Aggregation DatabaseEast AsianSub1614G=0.270A=0.730
The Genome Aggregation DatabaseEuropeSub18462G=0.376A=0.623
The Genome Aggregation DatabaseGlobalStudy-wide29928G=0.324A=0.676
The Genome Aggregation DatabaseOtherSub302G=0.250A=0.750
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.278A=0.721
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.359A=0.641
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs100706990.000162nicotine dependence17158188

eQTL of rs10070699 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10070699 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5135643688135644372E081-7568

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5135700942135701290E06849002
chr5135700942135701290E07349002
chr5135700942135701290E08249002