rs1007894

Homo sapiens
G>A
GPR137C : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0119 (3581/29932,GnomAD)
A=0092 (2695/29118,TOPMED)
A=0116 (579/5008,1000G)
A=0106 (409/3854,ALSPAC)
A=0113 (420/3708,TWINSUK)
chr14:52627877 (GRCh38.p7) (14q22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
4 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.52627877G>A
GRCh37.p13 chr 14NC_000014.8:g.53094595G>A

Gene: GPR137C, G protein-coupled receptor 137C(plus strand)

Molecule type Change Amino acid[Codon] SO Term
GPR137C transcript variant 2NM_001099652.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.921A=0.079
1000GenomesAmericanSub694G=0.940A=0.060
1000GenomesEast AsianSub1008G=0.871A=0.129
1000GenomesEuropeSub1006G=0.873A=0.127
1000GenomesGlobalStudy-wide5008G=0.884A=0.116
1000GenomesSouth AsianSub978G=0.820A=0.180
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.894A=0.106
The Genome Aggregation DatabaseAfricanSub8704G=0.918A=0.082
The Genome Aggregation DatabaseAmericanSub838G=0.910A=0.090
The Genome Aggregation DatabaseEast AsianSub1616G=0.832A=0.168
The Genome Aggregation DatabaseEuropeSub18472G=0.864A=0.135
The Genome Aggregation DatabaseGlobalStudy-wide29932G=0.880A=0.119
The Genome Aggregation DatabaseOtherSub302G=0.900A=0.100
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.907A=0.092
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.887A=0.113
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs10078940.000784alcohol dependence24277619

eQTL of rs1007894 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1007894 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr145306893353069029E068-25566
chr145306903153069162E068-25433
chr145305649553056576E073-38019
chr145309855953098714E0813964