rs1008509

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0219 (6572/29934,GnomAD)
C=0285 (8316/29118,TOPMED)
C=0208 (1040/5008,1000G)
C=0208 (803/3854,ALSPAC)
C=0201 (746/3708,TWINSUK)
chr17:50328890 (GRCh38.p7) (17q21.33)
ND
GWASdb2
1   publication(s)
See rs on genome
116 Enhancers around
21 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.50328890T>C
GRCh37.p13 chr 17NC_000017.10:g.48406251T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.627C=0.373
1000GenomesAmericanSub694T=0.740C=0.260
1000GenomesEast AsianSub1008T=0.964C=0.036
1000GenomesEuropeSub1006T=0.793C=0.207
1000GenomesGlobalStudy-wide5008T=0.792C=0.208
1000GenomesSouth AsianSub978T=0.880C=0.120
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.792C=0.208
The Genome Aggregation DatabaseAfricanSub8708T=0.651C=0.349
The Genome Aggregation DatabaseAmericanSub838T=0.690C=0.310
The Genome Aggregation DatabaseEast AsianSub1622T=0.967C=0.033
The Genome Aggregation DatabaseEuropeSub18464T=0.829C=0.170
The Genome Aggregation DatabaseGlobalStudy-wide29934T=0.780C=0.219
The Genome Aggregation DatabaseOtherSub302T=0.720C=0.280
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.714C=0.285
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.799C=0.201
PMID Title Author Journal
23542338A genomewide association study of smoking relapse in four European population-based samples.Tozzi FPsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs10085095.64E-06nicotine dependence (smoking)23542338

eQTL of rs1008509 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1008509 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr174838204648382135E067-24116
chr174838217148382457E067-23794
chr174842518848425312E06718937
chr174842532748425431E06719076
chr174843897448440269E06732723
chr174844038648440524E06734135
chr174844057348441475E06734322
chr174844151748442055E06735266
chr174844864248448846E06742391
chr174844889848449355E06742647
chr174836655148366658E068-39593
chr174836670248366936E068-39315
chr174836705848368182E068-38069
chr174838217148382457E068-23794
chr174842518848425312E06818937
chr174842532748425431E06819076
chr174842545248425551E06819201
chr174843897448440269E06832723
chr174844038648440524E06834135
chr174844057348441475E06834322
chr174844151748442055E06835266
chr174844207048442377E06835819
chr174844864248448846E06842391
chr174844889848449355E06842647
chr174842518848425312E06918937
chr174842532748425431E06919076
chr174842545248425551E06919201
chr174842565548425778E06919404
chr174842582548425909E06919574
chr174842597648426194E06919725
chr174842621448426278E06919963
chr174842628148426503E06920030
chr174843897448440269E06932723
chr174844038648440524E06934135
chr174844057348441475E06934322
chr174844151748442055E06935266
chr174844207048442377E06935819
chr174844254348442708E06936292
chr174844275148442817E06936500
chr174844282448442917E06936573
chr174844295248443022E06936701
chr174844864248448846E06942391
chr174844889848449355E06942647
chr174842518848425312E07018937
chr174842532748425431E07019076
chr174836578648366043E071-40208
chr174836609248366197E071-40054
chr174836622748366297E071-39954
chr174836655148366658E071-39593
chr174836670248366936E071-39315
chr174836705848368182E071-38069
chr174838217148382457E071-23794
chr174842217648422354E07115925
chr174842518848425312E07118937
chr174842532748425431E07119076
chr174842545248425551E07119201
chr174843897448440269E07132723
chr174844038648440524E07134135
chr174844057348441475E07134322
chr174844151748442055E07135266
chr174844207048442377E07135819
chr174844254348442708E07136292
chr174844275148442817E07136500
chr174844889848449355E07142647
chr174836655148366658E072-39593
chr174836670248366936E072-39315
chr174842518848425312E07218937
chr174842532748425431E07219076
chr174842545248425551E07219201
chr174842565548425778E07219404
chr174842582548425909E07219574
chr174842597648426194E07219725
chr174843897448440269E07232723
chr174844038648440524E07234135
chr174844057348441475E07234322
chr174844151748442055E07235266
chr174844207048442377E07235819
chr174844864248448846E07242391
chr174844889848449355E07242647
chr174838217148382457E073-23794
chr174840616148406506E0730
chr174840654748406597E073296
chr174842518848425312E07318937
chr174842532748425431E07319076
chr174842545248425551E07319201
chr174842565548425778E07319404
chr174842582548425909E07319574
chr174842597648426194E07319725
chr174842621448426278E07319963
chr174843897448440269E07332723
chr174844038648440524E07334135
chr174844057348441475E07334322
chr174844151748442055E07335266
chr174844864248448846E07342391
chr174844889848449355E07342647
chr174836670248366936E074-39315
chr174836705848368182E074-38069
chr174842518848425312E07418937
chr174842532748425431E07419076
chr174844038648440524E07434135
chr174844057348441475E07434322
chr174844151748442055E07435266
chr174844207048442377E07435819
chr174844864248448846E07442391
chr174844889848449355E07442647
chr174839527248395337E081-10914
chr174839596148396597E081-9654
chr174839662248396699E081-9552
chr174842518848425312E08118937
chr174844057348441475E08134322
chr174844151748442055E08135266
chr174844889848449355E08142647
chr174842518848425312E08218937
chr174844057348441475E08234322
chr174844824348448361E08241992
chr174844864248448846E08242391










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr174842241248424514E06716161
chr174844985948450914E06743608
chr174842241248424514E06816161
chr174844985948450914E06843608
chr174842241248424514E06916161
chr174844985948450914E06943608
chr174842241248424514E07016161
chr174844985948450914E07043608
chr174845112948451213E07044878
chr174842241248424514E07116161
chr174844985948450914E07143608
chr174845112948451213E07144878
chr174842241248424514E07216161
chr174844985948450914E07243608
chr174842241248424514E07316161
chr174844985948450914E07343608
chr174842241248424514E07416161
chr174844985948450914E07443608
chr174844985948450914E08143608
chr174842241248424514E08216161
chr174844985948450914E08243608