rs10089021

Homo sapiens
T>C
LOC105379315 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0222 (6654/29916,GnomAD)
C=0216 (6306/29118,TOPMED)
C=0280 (1402/5008,1000G)
C=0230 (887/3854,ALSPAC)
C=0219 (813/3708,TWINSUK)
chr8:20781983 (GRCh38.p7) (8p21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
53 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.20781983T>C
GRCh37.p13 chr 8NC_000008.10:g.20639494T>C

Gene: LOC105379315, uncharacterized LOC105379315(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105379315 transcriptXR_949569.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.789C=0.211
1000GenomesAmericanSub694T=0.740C=0.260
1000GenomesEast AsianSub1008T=0.658C=0.342
1000GenomesEuropeSub1006T=0.757C=0.243
1000GenomesGlobalStudy-wide5008T=0.720C=0.280
1000GenomesSouth AsianSub978T=0.640C=0.360
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.770C=0.230
The Genome Aggregation DatabaseAfricanSub8704T=0.806C=0.194
The Genome Aggregation DatabaseAmericanSub830T=0.770C=0.230
The Genome Aggregation DatabaseEast AsianSub1606T=0.638C=0.362
The Genome Aggregation DatabaseEuropeSub18474T=0.778C=0.221
The Genome Aggregation DatabaseGlobalStudy-wide29916T=0.777C=0.222
The Genome Aggregation DatabaseOtherSub302T=0.690C=0.310
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.783C=0.216
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.781C=0.219
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs100890218.1E-05alcoholism (heaviness of drinking)21529783

eQTL of rs10089021 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10089021 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr82059417220595288E070-44206
chr82059534420595496E070-43998
chr82065738020657513E07017886
chr82065755220657687E07018058
chr82065773020657780E07018236
chr82065779920657864E07018305
chr82065806220658171E07018568
chr82065830320658740E07018809
chr82065894020659010E07019446
chr82065905920659355E07019565
chr82067786020678001E07038366
chr82067816820678248E07038674
chr82067688520677572E07337391
chr82059169320591773E081-47721
chr82059226320592389E081-47105
chr82059246920592560E081-46934
chr82059299520593045E081-46449
chr82059322720593279E081-46215
chr82059341420593604E081-45890
chr82059397220594027E081-45467
chr82059417220595288E081-44206
chr82059534420595496E081-43998
chr82059605220596335E081-43159
chr82059646420597356E081-42138
chr82059739420597775E081-41719
chr82064657920646881E0817085
chr82064695020647000E0817456
chr82067680420676884E08137310
chr82067688520677572E08137391
chr82068288220683023E08143388
chr82068311320683163E08143619
chr82068323220684197E08143738
chr82058963220589682E082-49812
chr82059226320592389E082-47105
chr82059299520593045E082-46449
chr82059322720593279E082-46215
chr82059341420593604E082-45890
chr82059397220594027E082-45467
chr82059417220595288E082-44206
chr82059534420595496E082-43998
chr82059605220596335E082-43159
chr82064551720645889E0826023
chr82064593020646010E0826436
chr82064619020646240E0826696
chr82064637320646464E0826879
chr82064657920646881E0827085
chr82064695020647000E0827456
chr82065830320658740E08218809
chr82067688520677572E08237391
chr82067786020678001E08238366
chr82068288220683023E08243388
chr82068311320683163E08243619
chr82068323220684197E08243738