rs10091077

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0291 (8725/29900,GnomAD)
A==0279 (8124/29118,TOPMED)
A==0333 (1669/5008,1000G)
A==0337 (1297/3854,ALSPAC)
A==0330 (1223/3708,TWINSUK)
chr8:81793229 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
93 Enhancers around
34 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81793229A>G
GRCh37.p13 chr 8NC_000008.10:g.82705464A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.161G=0.839
1000GenomesAmericanSub694A=0.360G=0.640
1000GenomesEast AsianSub1008A=0.549G=0.451
1000GenomesEuropeSub1006A=0.339G=0.661
1000GenomesGlobalStudy-wide5008A=0.333G=0.667
1000GenomesSouth AsianSub978A=0.320G=0.680
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.337G=0.663
The Genome Aggregation DatabaseAfricanSub8696A=0.182G=0.818
The Genome Aggregation DatabaseAmericanSub834A=0.320G=0.680
The Genome Aggregation DatabaseEast AsianSub1610A=0.576G=0.424
The Genome Aggregation DatabaseEuropeSub18458A=0.316G=0.684
The Genome Aggregation DatabaseGlobalStudy-wide29900A=0.291G=0.708
The Genome Aggregation DatabaseOtherSub302A=0.380G=0.620
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.279G=0.721
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.330G=0.670
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs100910775.34E-05alcohol consumption23743675

eQTL of rs10091077 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10091077 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06177744135241213.4532e-23
cg23324259chr8:82754387SNX160.01878342246737589.6486e-16
cg27398817chr8:82754497SNX160.0379080385831951.3218e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E06721457
chr88272708482727145E06721620
chr88272739782727713E06721933
chr88275141582751459E06745951
chr88275155182751632E06746087
chr88275169382751743E06746229
chr88275176982751905E06746305
chr88275192082751978E06746456
chr88275205182752101E06746587
chr88275213682752286E06746672
chr88275242482752500E06746960
chr88275252382752586E06747059
chr88274913582749745E06843671
chr88275040382750493E06844939
chr88275055782750622E06845093
chr88275073382750913E06845269
chr88275118682751259E06845722
chr88275141582751459E06845951
chr88275155182751632E06846087
chr88275169382751743E06846229
chr88275242482752500E06846960
chr88275252382752586E06847059
chr88275264882752702E06847184
chr88275205182752101E06946587
chr88275213682752286E06946672
chr88275242482752500E06946960
chr88275252382752586E06947059
chr88275264882752702E06947184
chr88270876682709232E0703302
chr88270927582709325E0703811
chr88270935482709440E0703890
chr88273635982736422E07030895
chr88273760682737656E07032142
chr88273770482737783E07032240
chr88274913582749745E07043671
chr88272692182727044E07121457
chr88272739782727713E07121933
chr88275040382750493E07144939
chr88275055782750622E07145093
chr88275073382750913E07145269
chr88275176982751905E07146305
chr88275192082751978E07146456
chr88275205182752101E07146587
chr88275213682752286E07146672
chr88275242482752500E07146960
chr88275252382752586E07147059
chr88275264882752702E07147184
chr88269268482693377E072-12087
chr88272629482726439E07220830
chr88272692182727044E07221457
chr88272708482727145E07221620
chr88272739782727713E07221933
chr88272739782727713E07321933
chr88272692182727044E07421457
chr88275040382750493E07444939
chr88275055782750622E07445093
chr88275073382750913E07445269
chr88275118682751259E07445722
chr88275141582751459E07445951
chr88275155182751632E07446087
chr88275169382751743E07446229
chr88275176982751905E07446305
chr88275192082751978E07446456
chr88275205182752101E07446587
chr88275213682752286E07446672
chr88275242482752500E07446960
chr88275252382752586E07447059
chr88275264882752702E07447184
chr88269268482693377E081-12087
chr88274894182748991E08143477
chr88275118682751259E08145722
chr88275141582751459E08145951
chr88275155182751632E08146087
chr88275169382751743E08146229
chr88275176982751905E08146305
chr88275192082751978E08146456
chr88275205182752101E08146587
chr88275213682752286E08146672
chr88275242482752500E08146960
chr88275252382752586E08147059
chr88275264882752702E08147184
chr88269939382699447E082-6017
chr88269957982699654E082-5810
chr88274913582749745E08243671
chr88274982582749873E08244361
chr88275155182751632E08246087
chr88275169382751743E08246229
chr88275176982751905E08246305
chr88275192082751978E08246456
chr88275205182752101E08246587
chr88275213682752286E08246672
chr88275242482752500E08246960
chr88275252382752586E08247059










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E06747438
chr88275314082753307E06747676
chr88275349982753591E06748035
chr88275360282754599E06748138
chr88275349982753591E06848035
chr88275360282754599E06848138
chr88275290282753069E06947438
chr88275314082753307E06947676
chr88275349982753591E06948035
chr88275360282754599E06948138
chr88275290282753069E07047438
chr88275314082753307E07047676
chr88275349982753591E07048035
chr88275360282754599E07048138
chr88275290282753069E07147438
chr88275314082753307E07147676
chr88275349982753591E07148035
chr88275360282754599E07148138
chr88275290282753069E07247438
chr88275314082753307E07247676
chr88275349982753591E07248035
chr88275360282754599E07248138
chr88275290282753069E07347438
chr88275314082753307E07347676
chr88275349982753591E07348035
chr88275360282754599E07348138
chr88275314082753307E07447676
chr88275349982753591E07448035
chr88275360282754599E07448138
chr88275360282754599E08148138
chr88275290282753069E08247438
chr88275314082753307E08247676
chr88275349982753591E08248035
chr88275360282754599E08248138