rs10096565

Organism: Homo sapiens

Alleles: A>C / A>T

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C=0224 (6724/29912,GnomAD)
C=0272 (1361/5008,1000G)
C=0259 (998/3854,ALSPAC)
C=0252 (934/3708,TWINSUK)

Position: chr8:57757793 (GRCh38.p7) (8q12.1)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 195 Enhancers around

Promoter: 40 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 8	NC_000008.11:g.57757793A>C
GRCh38.p7 chr 8	NC_000008.11:g.57757793A>T
GRCh37.p13 chr 8	NC_000008.10:g.58670352A>C
GRCh37.p13 chr 8	NC_000008.10:g.58670352A>T

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.870	C=0.130
1000Genomes	American	Sub	694	A=0.750	C=0.250
1000Genomes	East Asian	Sub	1008	A=0.596	C=0.404
1000Genomes	Europe	Sub	1006	A=0.738	C=0.262
1000Genomes	Global	Study-wide	5008	A=0.728	C=0.272
1000Genomes	South Asian	Sub	978	A=0.650	C=0.350
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.741	C=0.259
The Genome Aggregation Database	African	Sub	8714	A=0.863	C=0.137
The Genome Aggregation Database	American	Sub	830	A=0.720	C=0.28,
The Genome Aggregation Database	East Asian	Sub	1602	A=0.566	C=0.434
The Genome Aggregation Database	Europe	Sub	18464	A=0.753	C=0.246
The Genome Aggregation Database	Global	Study-wide	29912	A=0.775	C=0.224
The Genome Aggregation Database	Other	Sub	302	A=0.790	C=0.20,
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.748	C=0.252

PMID	Title	Author	Journal
24277619	ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.	Quillen EE	Am J Med Genet B Neuropsychiatr Genet

SNP ID	p-value	Traits	Study
rs10096565	0.00041	alcohol dependence	24277619

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr8	18613287	18614152	E067	-42198
chr8	18663441	18663493	E067	7091
chr8	18663539	18663672	E067	7189
chr8	18667473	18667523	E067	11123
chr8	18667547	18667671	E067	11197
chr8	18667724	18667818	E067	11374
chr8	18696478	18697636	E067	40128
chr8	18697729	18697870	E067	41379
chr8	18697989	18698335	E067	41639
chr8	18698355	18698439	E067	42005
chr8	18698590	18698914	E067	42240
chr8	18698955	18699273	E067	42605
chr8	18699278	18699343	E067	42928
chr8	18699417	18699876	E067	43067
chr8	18701976	18702082	E067	45626
chr8	18702101	18702192	E067	45751
chr8	18702290	18702517	E067	45940
chr8	18702696	18702770	E067	46346
chr8	18702821	18703189	E067	46471
chr8	18705090	18705140	E067	48740
chr8	18615364	18615411	E068	-40939
chr8	18615495	18615539	E068	-40811
chr8	18615720	18615770	E068	-40580
chr8	18615839	18615883	E068	-40467
chr8	18615953	18616111	E068	-40239
chr8	18616266	18616680	E068	-39670
chr8	18626086	18626167	E068	-30183
chr8	18661974	18662151	E068	5624
chr8	18662177	18662298	E068	5827
chr8	18662301	18662363	E068	5951
chr8	18663441	18663493	E068	7091
chr8	18663539	18663672	E068	7189
chr8	18663823	18663917	E068	7473
chr8	18664034	18664112	E068	7684
chr8	18664117	18664176	E068	7767
chr8	18664187	18664238	E068	7837
chr8	18664305	18664356	E068	7955
chr8	18664426	18664504	E068	8076
chr8	18664533	18664590	E068	8183
chr8	18691963	18692120	E068	35613
chr8	18696478	18697636	E068	40128
chr8	18697729	18697870	E068	41379
chr8	18697989	18698335	E068	41639
chr8	18698355	18698439	E068	42005
chr8	18698590	18698914	E068	42240
chr8	18698955	18699273	E068	42605
chr8	18699278	18699343	E068	42928
chr8	18699417	18699876	E068	43067
chr8	18701976	18702082	E068	45626
chr8	18702101	18702192	E068	45751
chr8	18702290	18702517	E068	45940
chr8	18702696	18702770	E068	46346
chr8	18702821	18703189	E068	46471
chr8	18703657	18705062	E068	47307
chr8	18705090	18705140	E068	48740
chr8	18625944	18626031	E069	-30319
chr8	18626086	18626167	E069	-30183
chr8	18626182	18626343	E069	-30007
chr8	18646342	18646451	E069	-9899
chr8	18663260	18663312	E069	6910
chr8	18663441	18663493	E069	7091
chr8	18663539	18663672	E069	7189
chr8	18663823	18663917	E069	7473
chr8	18664034	18664112	E069	7684
chr8	18664117	18664176	E069	7767
chr8	18664187	18664238	E069	7837
chr8	18664305	18664356	E069	7955
chr8	18664426	18664504	E069	8076
chr8	18664533	18664590	E069	8183
chr8	18666840	18666911	E069	10490
chr8	18696478	18697636	E069	40128
chr8	18697729	18697870	E069	41379
chr8	18697989	18698335	E069	41639
chr8	18698355	18698439	E069	42005
chr8	18698590	18698914	E069	42240
chr8	18698955	18699273	E069	42605
chr8	18699278	18699343	E069	42928
chr8	18699417	18699876	E069	43067
chr8	18702290	18702517	E069	45940
chr8	18702696	18702770	E069	46346
chr8	18702821	18703189	E069	46471
chr8	18703657	18705062	E069	47307
chr8	18705090	18705140	E069	48740
chr8	18616266	18616680	E070	-39670
chr8	18613287	18614152	E071	-42198
chr8	18615720	18615770	E071	-40580
chr8	18627275	18627355	E071	-28995
chr8	18627468	18627824	E071	-28526
chr8	18646611	18646727	E071	-9623
chr8	18663539	18663672	E071	7189
chr8	18663823	18663917	E071	7473
chr8	18664034	18664112	E071	7684
chr8	18664117	18664176	E071	7767
chr8	18664187	18664238	E071	7837
chr8	18664305	18664356	E071	7955
chr8	18664426	18664504	E071	8076
chr8	18664533	18664590	E071	8183
chr8	18667473	18667523	E071	11123
chr8	18667547	18667671	E071	11197
chr8	18671527	18671668	E071	15177
chr8	18671738	18672073	E071	15388
chr8	18672190	18672444	E071	15840
chr8	18691605	18691661	E071	35255
chr8	18691963	18692120	E071	35613
chr8	18696478	18697636	E071	40128
chr8	18697729	18697870	E071	41379
chr8	18697989	18698335	E071	41639
chr8	18698355	18698439	E071	42005
chr8	18698590	18698914	E071	42240
chr8	18698955	18699273	E071	42605
chr8	18699278	18699343	E071	42928
chr8	18699417	18699876	E071	43067
chr8	18701976	18702082	E071	45626
chr8	18702101	18702192	E071	45751
chr8	18702290	18702517	E071	45940
chr8	18702696	18702770	E071	46346
chr8	18702821	18703189	E071	46471
chr8	18705090	18705140	E071	48740
chr8	18647091	18647460	E072	-8890
chr8	18656337	18656815	E072	0
chr8	18656826	18656998	E072	476
chr8	18667473	18667523	E072	11123
chr8	18667547	18667671	E072	11197
chr8	18691963	18692120	E072	35613
chr8	18696478	18697636	E072	40128
chr8	18697729	18697870	E072	41379
chr8	18697989	18698335	E072	41639
chr8	18698355	18698439	E072	42005
chr8	18698590	18698914	E072	42240
chr8	18698955	18699273	E072	42605
chr8	18699278	18699343	E072	42928
chr8	18699417	18699876	E072	43067
chr8	18699968	18700018	E072	43618
chr8	18701976	18702082	E072	45626
chr8	18702101	18702192	E072	45751
chr8	18702290	18702517	E072	45940
chr8	18702696	18702770	E072	46346
chr8	18702821	18703189	E072	46471
chr8	18703657	18705062	E072	47307
chr8	18705090	18705140	E072	48740
chr8	18613287	18614152	E073	-42198
chr8	18672190	18672444	E073	15840
chr8	18691963	18692120	E073	35613
chr8	18696478	18697636	E073	40128
chr8	18697729	18697870	E073	41379
chr8	18697989	18698335	E073	41639
chr8	18698355	18698439	E073	42005
chr8	18698590	18698914	E073	42240
chr8	18698955	18699273	E073	42605
chr8	18699278	18699343	E073	42928
chr8	18699417	18699876	E073	43067
chr8	18699968	18700018	E073	43618
chr8	18701976	18702082	E073	45626
chr8	18702101	18702192	E073	45751
chr8	18702290	18702517	E073	45940
chr8	18702696	18702770	E073	46346
chr8	18702821	18703189	E073	46471
chr8	18705090	18705140	E073	48740
chr8	18615364	18615411	E074	-40939
chr8	18616266	18616680	E074	-39670
chr8	18617195	18617245	E074	-39105
chr8	18626086	18626167	E074	-30183
chr8	18626182	18626343	E074	-30007
chr8	18627468	18627824	E074	-28526
chr8	18627908	18628720	E074	-27630
chr8	18663539	18663672	E074	7189
chr8	18664187	18664238	E074	7837
chr8	18664305	18664356	E074	7955
chr8	18664426	18664504	E074	8076
chr8	18664533	18664590	E074	8183
chr8	18666840	18666911	E074	10490
chr8	18671738	18672073	E074	15388
chr8	18672190	18672444	E074	15840
chr8	18691963	18692120	E074	35613
chr8	18696478	18697636	E074	40128
chr8	18697729	18697870	E074	41379
chr8	18697989	18698335	E074	41639
chr8	18698355	18698439	E074	42005
chr8	18698590	18698914	E074	42240
chr8	18698955	18699273	E074	42605
chr8	18699278	18699343	E074	42928
chr8	18699417	18699876	E074	43067
chr8	18699968	18700018	E074	43618
chr8	18702290	18702517	E074	45940
chr8	18702696	18702770	E074	46346
chr8	18702821	18703189	E074	46471
chr8	18703657	18705062	E074	47307
chr8	18705090	18705140	E074	48740
chr8	18606411	18606479	E081	-49871
chr8	18613287	18614152	E081	-42198
chr8	18615495	18615539	E081	-40811
chr8	18615953	18616111	E081	-40239
chr8	18656826	18656998	E082	476
chr8	18698590	18698914	E082	42240
chr8	18698955	18699273	E082	42605

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr8	18664684	18665063	E067	8334
chr8	18665152	18665440	E067	8802
chr8	18665479	18665586	E067	9129
chr8	18665689	18665751	E067	9339
chr8	18665999	18666112	E067	9649
chr8	18666271	18666619	E067	9921
chr8	18664684	18665063	E068	8334
chr8	18665152	18665440	E068	8802
chr8	18665479	18665586	E068	9129
chr8	18665689	18665751	E068	9339
chr8	18665999	18666112	E068	9649
chr8	18666271	18666619	E068	9921
chr8	18664684	18665063	E069	8334
chr8	18665152	18665440	E069	8802
chr8	18665479	18665586	E069	9129
chr8	18665689	18665751	E069	9339
chr8	18665999	18666112	E069	9649
chr8	18666271	18666619	E069	9921
chr8	18664684	18665063	E071	8334
chr8	18665152	18665440	E071	8802
chr8	18665479	18665586	E071	9129
chr8	18665689	18665751	E071	9339
chr8	18665999	18666112	E071	9649
chr8	18666271	18666619	E071	9921
chr8	18664684	18665063	E072	8334
chr8	18665152	18665440	E072	8802
chr8	18665479	18665586	E072	9129
chr8	18665689	18665751	E072	9339
chr8	18665999	18666112	E072	9649
chr8	18666271	18666619	E072	9921
chr8	18664684	18665063	E073	8334
chr8	18665152	18665440	E073	8802
chr8	18665999	18666112	E073	9649
chr8	18666271	18666619	E073	9921
chr8	18664684	18665063	E074	8334
chr8	18665152	18665440	E074	8802
chr8	18665479	18665586	E074	9129
chr8	18665689	18665751	E074	9339
chr8	18665999	18666112	E074	9649
chr8	18666271	18666619	E074	9921

rs10096565

Genomic Coordinates

Population Frequency

P-Value

eQTL of rs10096565 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs10096565 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)

Promoter Annotation (GRCh37.p13)