rs1009746

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0416 (12469/29920,GnomAD)
G=0378 (11021/29118,TOPMED)
G=0445 (2231/5008,1000G)
T==0487 (1876/3854,ALSPAC)
T==0482 (1788/3708,TWINSUK)
chr11:116248195 (GRCh38.p7) (11q23.3)
AD
GWASdb2
1   publication(s)
See rs on genome
173 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.116248195T>G
GRCh37.p13 chr 11NC_000011.9:g.116118912T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.803G=0.197
1000GenomesAmericanSub694T=0.600G=0.400
1000GenomesEast AsianSub1008T=0.481G=0.519
1000GenomesEuropeSub1006T=0.482G=0.518
1000GenomesGlobalStudy-wide5008T=0.555G=0.445
1000GenomesSouth AsianSub978T=0.330G=0.670
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.487G=0.513
The Genome Aggregation DatabaseAfricanSub8722T=0.770G=0.230
The Genome Aggregation DatabaseAmericanSub838T=0.620G=0.380
The Genome Aggregation DatabaseEast AsianSub1612T=0.491G=0.509
The Genome Aggregation DatabaseEuropeSub18448T=0.501G=0.498
The Genome Aggregation DatabaseGlobalStudy-wide29920T=0.583G=0.416
The Genome Aggregation DatabaseOtherSub300T=0.550G=0.450
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.621G=0.378
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.482G=0.518
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs10097460.000018Alcohol dependence (early age of onset)20201924
rs10097460.0000183alcoholismpha002893
rs10097460.00004alcohol dependence20201924
rs10097460.0000403alcoholismpha002892

eQTL of rs1009746 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1009746 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr11116089825116089984E067-28928
chr11116095592116095644E067-23268
chr11116095694116095765E067-23147
chr11116095804116096349E067-22563
chr11116095592116095644E068-23268
chr11116095694116095765E068-23147
chr11116099906116101440E068-17472
chr11116127862116128078E0688950
chr11116133891116134128E06814979
chr11116089720116089802E069-29110
chr11116089825116089984E069-28928
chr11116090062116090437E069-28475
chr11116095189116095526E069-23386
chr11116095592116095644E069-23268
chr11116095694116095765E069-23147
chr11116146992116148073E06928080
chr11116069983116070181E070-48731
chr11116070403116070475E070-48437
chr11116070568116070654E070-48258
chr11116087692116088108E070-30804
chr11116090062116090437E070-28475
chr11116090459116090536E070-28376
chr11116094790116094855E070-24057
chr11116095037116095119E070-23793
chr11116095189116095526E070-23386
chr11116095592116095644E070-23268
chr11116095694116095765E070-23147
chr11116095804116096349E070-22563
chr11116096354116096463E070-22449
chr11116096588116096789E070-22123
chr11116099356116099477E070-19435
chr11116099519116099573E070-19339
chr11116099906116101440E070-17472
chr11116101508116101564E070-17348
chr11116101588116101684E070-17228
chr11116101846116101933E070-16979
chr11116102142116102668E070-16244
chr11116102787116102841E070-16071
chr11116103046116103101E070-15811
chr11116103133116103547E070-15365
chr11116103566116103710E070-15202
chr11116103799116103986E070-14926
chr11116104186116104374E070-14538
chr11116104419116104679E070-14233
chr11116113708116113782E070-5130
chr11116113863116113913E070-4999
chr11116113940116113990E070-4922
chr11116114823116114863E070-4049
chr11116114872116114984E070-3928
chr11116114994116115094E070-3818
chr11116115422116115658E070-3254
chr11116115669116115940E070-2972
chr11116120645116120695E0701733
chr11116133279116133345E07014367
chr11116133426116133511E07014514
chr11116133516116133566E07014604
chr11116133891116134128E07014979
chr11116134195116134902E07015283
chr11116134996116135069E07016084
chr11116136393116136443E07017481
chr11116136598116136687E07017686
chr11116136712116136759E07017800
chr11116137006116137218E07018094
chr11116137366116137446E07018454
chr11116137818116137899E07018906
chr11116138000116138126E07019088
chr11116143100116143199E07024188
chr11116144276116144347E07025364
chr11116144512116144570E07025600
chr11116144870116144920E07025958
chr11116145010116145973E07026098
chr11116146041116146091E07027129
chr11116146122116146179E07027210
chr11116146455116146643E07027543
chr11116146827116146990E07027915
chr11116146992116148073E07028080
chr11116148123116148187E07029211
chr11116149494116149683E07030582
chr11116149740116149823E07030828
chr11116150195116150728E07031283
chr11116150970116151021E07032058
chr11116155376116155466E07036464
chr11116155756116156105E07036844
chr11116156163116156293E07037251
chr11116095037116095119E071-23793
chr11116095189116095526E071-23386
chr11116095592116095644E071-23268
chr11116095694116095765E071-23147
chr11116095804116096349E071-22563
chr11116095592116095644E072-23268
chr11116095694116095765E072-23147
chr11116095804116096349E072-22563
chr11116133891116134128E07214979
chr11116089720116089802E073-29110
chr11116089825116089984E073-28928
chr11116090062116090437E073-28475
chr11116090459116090536E073-28376
chr11116094656116094732E073-24180
chr11116094790116094855E073-24057
chr11116095189116095526E073-23386
chr11116095592116095644E073-23268
chr11116095694116095765E073-23147
chr11116136712116136759E07317800
chr11116146827116146990E07327915
chr11116146992116148073E07328080
chr11116078972116079022E081-39890
chr11116090062116090437E081-28475
chr11116090459116090536E081-28376
chr11116095189116095526E081-23386
chr11116095592116095644E081-23268
chr11116095694116095765E081-23147
chr11116095804116096349E081-22563
chr11116096354116096463E081-22449
chr11116096588116096789E081-22123
chr11116099906116101440E081-17472
chr11116101508116101564E081-17348
chr11116101588116101684E081-17228
chr11116101846116101933E081-16979
chr11116120645116120695E0811733
chr11116133426116133511E08114514
chr11116133516116133566E08114604
chr11116133891116134128E08114979
chr11116134195116134902E08115283
chr11116134996116135069E08116084
chr11116141106116141156E08122194
chr11116141462116141717E08122550
chr11116141981116142083E08123069
chr11116142476116142516E08123564
chr11116143100116143199E08124188
chr11116144276116144347E08125364
chr11116144512116144570E08125600
chr11116144870116144920E08125958
chr11116145010116145973E08126098
chr11116146041116146091E08127129
chr11116146122116146179E08127210
chr11116146455116146643E08127543
chr11116146827116146990E08127915
chr11116146992116148073E08128080
chr11116149494116149683E08130582
chr11116149740116149823E08130828
chr11116150195116150728E08131283
chr11116150970116151021E08132058
chr11116155376116155466E08136464
chr11116155756116156105E08136844
chr11116156163116156293E08137251
chr11116156915116156965E08138003
chr11116158328116158609E08139416
chr11116158700116158867E08139788
chr11116090062116090437E082-28475
chr11116090459116090536E082-28376
chr11116095189116095526E082-23386
chr11116095592116095644E082-23268
chr11116095694116095765E082-23147
chr11116095804116096349E082-22563
chr11116096354116096463E082-22449
chr11116096588116096789E082-22123
chr11116099906116101440E082-17472
chr11116101508116101564E082-17348
chr11116101588116101684E082-17228
chr11116133891116134128E08214979
chr11116134195116134902E08215283
chr11116136598116136687E08217686
chr11116136712116136759E08217800
chr11116137006116137218E08218094
chr11116137366116137446E08218454
chr11116144512116144570E08225600
chr11116144870116144920E08225958
chr11116145010116145973E08226098
chr11116146041116146091E08227129
chr11116146122116146179E08227210
chr11116155756116156105E08236844
chr11116156163116156293E08237251
chr11116156915116156965E08238003