rs10115383

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A==0301 (9023/29920,GnomAD)
A==0305 (8885/29118,TOPMED)
A==0351 (1758/5008,1000G)
A==0278 (1070/3854,ALSPAC)
A==0270 (1003/3708,TWINSUK)

Position: chr9:100608250 (GRCh38.p7) (9q31.1)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 67 Enhancers around

Promoter: 10 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 9	NC_000009.12:g.100608250A>G
GRCh37.p13 chr 9	NC_000009.11:g.103370532A>G

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.390	G=0.610
1000Genomes	American	Sub	694	A=0.270	G=0.730
1000Genomes	East Asian	Sub	1008	A=0.373	G=0.627
1000Genomes	Europe	Sub	1006	A=0.307	G=0.693
1000Genomes	Global	Study-wide	5008	A=0.351	G=0.649
1000Genomes	South Asian	Sub	978	A=0.380	G=0.620
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.278	G=0.722
The Genome Aggregation Database	African	Sub	8710	A=0.357	G=0.643
The Genome Aggregation Database	American	Sub	836	A=0.250	G=0.750
The Genome Aggregation Database	East Asian	Sub	1606	A=0.336	G=0.664
The Genome Aggregation Database	Europe	Sub	18466	A=0.274	G=0.725
The Genome Aggregation Database	Global	Study-wide	29920	A=0.301	G=0.698
The Genome Aggregation Database	Other	Sub	302	A=0.320	G=0.680
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.305	G=0.694
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.270	G=0.730

PMID	Title	Author	Journal
19268276	Genome-wide association study of smoking initiation and current smoking.	Vink JM	Am J Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs10115383	7.69E-05	nicotine smoking	19268276

eQTL of rs10115383 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10115383 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr9	103352460	103352594	E067	-17938
chr9	103352753	103353185	E067	-17347
chr9	103353216	103353781	E067	-16751
chr9	103353794	103353939	E067	-16593
chr9	103354032	103354164	E067	-16368
chr9	103357511	103357597	E067	-12935
chr9	103357615	103358575	E067	-11957
chr9	103361852	103361973	E067	-8559
chr9	103353216	103353781	E068	-16751
chr9	103360485	103360681	E068	-9851
chr9	103352753	103353185	E069	-17347
chr9	103353216	103353781	E069	-16751
chr9	103353794	103353939	E069	-16593
chr9	103354032	103354164	E069	-16368
chr9	103354484	103354662	E069	-15870
chr9	103357615	103358575	E069	-11957
chr9	103359406	103360273	E070	-10259
chr9	103360287	103360426	E070	-10106
chr9	103360485	103360681	E070	-9851
chr9	103400771	103400821	E070	30239
chr9	103400823	103400895	E070	30291
chr9	103401000	103401070	E070	30468
chr9	103401331	103401381	E070	30799
chr9	103402259	103402349	E070	31727
chr9	103402458	103402548	E070	31926
chr9	103403061	103403198	E070	32529
chr9	103351402	103351489	E071	-19043
chr9	103351568	103351630	E071	-18902
chr9	103351996	103352121	E071	-18411
chr9	103352460	103352594	E071	-17938
chr9	103352753	103353185	E071	-17347
chr9	103353216	103353781	E071	-16751
chr9	103353794	103353939	E071	-16593
chr9	103354032	103354164	E071	-16368
chr9	103359406	103360273	E071	-10259
chr9	103360287	103360426	E071	-10106
chr9	103360485	103360681	E071	-9851
chr9	103363511	103363912	E071	-6620
chr9	103363926	103364039	E071	-6493
chr9	103323535	103323872	E072	-46660
chr9	103351402	103351489	E072	-19043
chr9	103351568	103351630	E072	-18902
chr9	103351996	103352121	E072	-18411
chr9	103352460	103352594	E072	-17938
chr9	103352753	103353185	E072	-17347
chr9	103353216	103353781	E072	-16751
chr9	103353794	103353939	E072	-16593
chr9	103354032	103354164	E072	-16368
chr9	103357615	103358575	E072	-11957
chr9	103337454	103337506	E073	-33026
chr9	103352460	103352594	E073	-17938
chr9	103353216	103353781	E073	-16751
chr9	103353794	103353939	E073	-16593
chr9	103322264	103322314	E074	-48218
chr9	103351996	103352121	E074	-18411
chr9	103352460	103352594	E074	-17938
chr9	103352753	103353185	E074	-17347
chr9	103353216	103353781	E074	-16751
chr9	103353794	103353939	E074	-16593
chr9	103354032	103354164	E074	-16368
chr9	103333007	103333076	E081	-37456
chr9	103333179	103333244	E081	-37288
chr9	103364648	103365055	E081	-5477
chr9	103367804	103367985	E081	-2547
chr9	103357615	103358575	E082	-11957
chr9	103367693	103367743	E082	-2789
chr9	103367804	103367985	E082	-2547

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr9	103360718	103361792	E067	-8740
chr9	103360718	103361792	E068	-8740
chr9	103360718	103361792	E069	-8740
chr9	103360718	103361792	E070	-8740
chr9	103360718	103361792	E071	-8740
chr9	103360718	103361792	E072	-8740
chr9	103360718	103361792	E073	-8740
chr9	103360718	103361792	E074	-8740
chr9	103360718	103361792	E081	-8740
chr9	103360718	103361792	E082	-8740