rs10137287

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0490 (14639/29858,GnomAD)
G==0428 (12478/29118,TOPMED)
G==0458 (2292/5008,1000G)
A=0374 (1443/3854,ALSPAC)
A=0388 (1439/3708,TWINSUK)
chr14:27824902 (GRCh38.p7) (14q12)
AD
GWASdb2
1   publication(s)
See rs on genome
6 Enhancers around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.27824902G>A
GRCh37.p13 chr 14NC_000014.8:g.28294108G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.156A=0.844
1000GenomesAmericanSub694G=0.630A=0.370
1000GenomesEast AsianSub1008G=0.577A=0.423
1000GenomesEuropeSub1006G=0.605A=0.395
1000GenomesGlobalStudy-wide5008G=0.458A=0.542
1000GenomesSouth AsianSub978G=0.470A=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.626A=0.374
The Genome Aggregation DatabaseAfricanSub8698G=0.213A=0.787
The Genome Aggregation DatabaseAmericanSub836G=0.720A=0.280
The Genome Aggregation DatabaseEast AsianSub1608G=0.609A=0.391
The Genome Aggregation DatabaseEuropeSub18414G=0.629A=0.370
The Genome Aggregation DatabaseGlobalStudy-wide29858G=0.509A=0.490
The Genome Aggregation DatabaseOtherSub302G=0.650A=0.350
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.428A=0.571
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.612A=0.388
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs101372870.000171alcohol consumption (maxi-drinks)24277619

eQTL of rs10137287 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10137287 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr142826868728268754E068-25354
chr142826912228269196E068-24912
chr142828547428285568E070-8540
chr142828584928285932E070-8176
chr142830801028308139E07013902
chr142826912228269196E072-24912



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr142828465028284789E067-9319
chr142828486928285086E067-9022
chr142828465028284789E068-9319
chr142828486928285086E068-9022
chr142828465028284789E069-9319
chr142828486928285086E069-9022
chr142828465028284789E071-9319
chr142828486928285086E071-9022
chr142828465028284789E072-9319
chr142828486928285086E072-9022
chr142828465028284789E074-9319
chr142828486928285086E074-9022
chr142828486928285086E082-9022