rs1014674

Homo sapiens
C>A / C>T
None
Check p-value
SNV (Single Nucleotide Variation)
A=0335 (10019/29856,GnomAD)
A=0348 (10146/29114,TOPMED)
A=0327 (1638/5008,1000G)
A=0284 (1094/3854,ALSPAC)
A=0287 (1065/3708,TWINSUK)
chr22:48057849 (GRCh38.p7) (22q13.31)
AD
GWASdb2
1   publication(s)
See rs on genome
185 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.48057849C>A
GRCh38.p7 chr 22NC_000022.11:g.48057849C>T
GRCh37.p13 chr 22NC_000022.10:g.48453666C>A
GRCh37.p13 chr 22NC_000022.10:g.48453666C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.554A=0.446
1000GenomesAmericanSub694C=0.630A=0.370
1000GenomesEast AsianSub1008C=0.679A=0.321
1000GenomesEuropeSub1006C=0.717A=0.283
1000GenomesGlobalStudy-wide5008C=0.673A=0.327
1000GenomesSouth AsianSub978C=0.810A=0.190
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.716A=0.284
The Genome Aggregation DatabaseAfricanSub8690C=0.572T=0.000
The Genome Aggregation DatabaseAmericanSub838C=0.650T=0.00,
The Genome Aggregation DatabaseEast AsianSub1608C=0.687T=0.000
The Genome Aggregation DatabaseEuropeSub18418C=0.705T=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29856C=0.664T=0.000
The Genome Aggregation DatabaseOtherSub302C=0.760T=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29114C=0.651A=0.348
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.713A=0.287
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs10146743.02E-05alcohol dependence21703634

eQTL of rs1014674 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1014674 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr224092944940931379E067-40854
chr224093138740931469E067-40764
chr224096314740963538E067-8695
chr224096354240963627E067-8606
chr224096381240963942E067-8291
chr224096403340964268E067-7965
chr224096442640964491E067-7742
chr224096478640964838E067-7395
chr224096509940965159E067-7074
chr224096517740965245E067-6988
chr224097916340979443E0676930
chr224099293840993176E06720705
chr224099325640993447E06721023
chr224099347440994330E06721241
chr224092944940931379E068-40854
chr224093138740931469E068-40764
chr224095663840956890E068-15343
chr224095690640957036E068-15197
chr224096303340963077E068-9156
chr224096314740963538E068-8695
chr224096354240963627E068-8606
chr224096381240963942E068-8291
chr224096403340964268E068-7965
chr224096442640964491E068-7742
chr224096478640964838E068-7395
chr224096509940965159E068-7074
chr224096517740965245E068-6988
chr224097916340979443E0686930
chr224099325640993447E06821023
chr224099347440994330E06821241
chr224099445940994587E06822226
chr224099805740998546E06825824
chr224099890740998947E06826674
chr224099907340999698E06826840
chr224100193741002660E06829704
chr224100266141002725E06830428
chr224100274241002930E06830509
chr224100638841006449E06834155
chr224100646041006597E06834227
chr224100668341006733E06834450
chr224092944940931379E069-40854
chr224094928140949431E069-22802
chr224094962340949700E069-22533
chr224094974140949791E069-22442
chr224095663840956890E069-15343
chr224095690640957036E069-15197
chr224096314740963538E069-8695
chr224096354240963627E069-8606
chr224096381240963942E069-8291
chr224096403340964268E069-7965
chr224096442640964491E069-7742
chr224096478640964838E069-7395
chr224097867140978716E0696438
chr224097916340979443E0696930
chr224098287240983655E06910639
chr224098960540990462E06917372
chr224099279740992847E06920564
chr224099293840993176E06920705
chr224099325640993447E06921023
chr224099347440994330E06921241
chr224099794540998029E06925712
chr224099805740998546E06925824
chr224099890740998947E06926674
chr224099907340999698E06926840
chr224100638841006449E06934155
chr224100646041006597E06934227
chr224100668341006733E06934450
chr224095268140952887E070-19346
chr224095306040953220E070-19013
chr224102066241020728E07048429
chr224102089041021085E07048657
chr224092944940931379E071-40854
chr224093138740931469E071-40764
chr224093637040936590E071-35643
chr224093667540936729E071-35504
chr224093684040936946E071-35287
chr224093702040937070E071-35163
chr224094892740949031E071-23202
chr224094908440949156E071-23077
chr224094928140949431E071-22802
chr224094962340949700E071-22533
chr224094974140949791E071-22442
chr224095268140952887E071-19346
chr224095306040953220E071-19013
chr224095330140953375E071-18858
chr224096314740963538E071-8695
chr224096354240963627E071-8606
chr224096381240963942E071-8291
chr224096403340964268E071-7965
chr224096442640964491E071-7742
chr224096478640964838E071-7395
chr224096509940965159E071-7074
chr224096517740965245E071-6988
chr224097867140978716E0716438
chr224097916340979443E0716930
chr224097947440979636E0717241
chr224099279740992847E07120564
chr224099293840993176E07120705
chr224099325640993447E07121023
chr224099347440994330E07121241
chr224099445940994587E07122226
chr224099890740998947E07126674
chr224100120541001273E07128972
chr224100135641001484E07129123
chr224100178241001934E07129549
chr224100638841006449E07134155
chr224100646041006597E07134227
chr224100668341006733E07134450
chr224100923741009281E07137004
chr224100945541009576E07137222
chr224092944940931379E072-40854
chr224093138740931469E072-40764
chr224093171540931775E072-40458
chr224093179440931973E072-40260
chr224094928140949431E072-22802
chr224096381240963942E072-8291
chr224096403340964268E072-7965
chr224096442640964491E072-7742
chr224096478640964838E072-7395
chr224096509940965159E072-7074
chr224096517740965245E072-6988
chr224099325640993447E07221023
chr224099347440994330E07221241
chr224099644340996493E07224210
chr224099657640996641E07224343
chr224099702240997095E07224789
chr224099794540998029E07225712
chr224099805740998546E07225824
chr224100352341003611E07231290
chr224100361341003733E07231380
chr224092591440926115E073-46118
chr224092614440926237E073-45996
chr224092679640926840E073-45393
chr224092685840926997E073-45236
chr224092701840927084E073-45149
chr224092712240927201E073-45032
chr224092944940931379E073-40854
chr224097916340979443E0736930
chr224097947440979636E0737241
chr224099325640993447E07321023
chr224099347440994330E07321241
chr224099794540998029E07325712
chr224099805740998546E07325824
chr224099890740998947E07326674
chr224099907340999698E07326840
chr224092858740929383E074-42850
chr224092944940931379E074-40854
chr224094928140949431E074-22802
chr224094962340949700E074-22533
chr224094974140949791E074-22442
chr224096303340963077E074-9156
chr224096314740963538E074-8695
chr224096354240963627E074-8606
chr224096381240963942E074-8291
chr224096403340964268E074-7965
chr224096442640964491E074-7742
chr224096478640964838E074-7395
chr224097867140978716E0746438
chr224097916340979443E0746930
chr224097947440979636E0747241
chr224098960540990462E07417372
chr224099051040991305E07418277
chr224099141840991468E07419185
chr224099152540991839E07419292
chr224099347440994330E07421241
chr224099794540998029E07425712
chr224099805740998546E07425824
chr224099890740998947E07426674
chr224099907340999698E07426840
chr224092614440926237E081-45996
chr224092679640926840E081-45393
chr224092772540927765E081-44468
chr224092858740929383E081-42850
chr224092944940931379E081-40854
chr224093138740931469E081-40764
chr224099293840993176E08120705
chr224099325640993447E08121023
chr224099347440994330E08121241
chr224092701840927084E082-45149
chr224092712240927201E082-45032
chr224092740840927454E082-44779
chr224092772540927765E082-44468
chr224099325640993447E08221023
chr224099347440994330E08221241
chr224100815541008306E08235922