rs10153321

Homo sapiens
G>A
MYOM1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0082 (2472/29972,GnomAD)
A=0102 (2997/29118,TOPMED)
A=0081 (405/5008,1000G)
A=0060 (233/3854,ALSPAC)
A=0068 (253/3708,TWINSUK)
chr18:3176379 (GRCh38.p7) (18p11.31)
ND
GWASdb2
1   publication(s)
See rs on genome
21 Enhancers around
4 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.3176379G>A
GRCh37.p13 chr 18NC_000018.9:g.3176377G>A
MYOM1 RefSeqGene LRG_426

Gene: MYOM1, myomesin 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
MYOM1 transcript variant 1NM_003803.3:c.N/AIntron Variant
MYOM1 transcript variant 2NM_019856.1:c.N/AIntron Variant
MYOM1 transcript variant X2XM_017026062.1:c.N/AIntron Variant
MYOM1 transcript variant X3XR_935071.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.866A=0.134
1000GenomesAmericanSub694G=0.930A=0.070
1000GenomesEast AsianSub1008G=0.992A=0.008
1000GenomesEuropeSub1006G=0.912A=0.088
1000GenomesGlobalStudy-wide5008G=0.919A=0.081
1000GenomesSouth AsianSub978G=0.920A=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.940A=0.060
The Genome Aggregation DatabaseAfricanSub8716G=0.847A=0.153
The Genome Aggregation DatabaseAmericanSub836G=0.940A=0.060
The Genome Aggregation DatabaseEast AsianSub1622G=0.987A=0.013
The Genome Aggregation DatabaseEuropeSub18496G=0.943A=0.056
The Genome Aggregation DatabaseGlobalStudy-wide29972G=0.917A=0.082
The Genome Aggregation DatabaseOtherSub302G=0.930A=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.897A=0.102
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.932A=0.068
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs101533218.73E-07alcohol and nictotine co-dependence20158304

eQTL of rs10153321 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10153321 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1831289553129816E067-46561
chr1831298773129937E067-46440
chr1832094803209635E06733103
chr1832097153209775E06733338
chr1832112003212022E06834823
chr1832192143221043E06842837
chr1831288003128868E069-47509
chr1831289553129816E069-46561
chr1831298773129937E069-46440
chr1831358233135905E069-40472
chr1832112003212022E06934823
chr1832192143221043E06942837
chr1832112003212022E07134823
chr1831298773129937E072-46440
chr1831358233135905E072-40472
chr1831288003128868E074-47509
chr1831289553129816E074-46561
chr1831298773129937E074-46440
chr1832112003212022E07434823
chr1832255503225932E07449173
chr1832260833226328E07449706






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1832189113219179E06842534
chr1831355813135782E071-40595
chr1832189113219179E07142534
chr1831355813135782E074-40595