rs10172167

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
T==0198 (5900/29746,GnomAD)
T==0176 (5134/29116,TOPMED)
T==0260 (1301/5008,1000G)
T==0231 (891/3854,ALSPAC)
T==0231 (857/3708,TWINSUK)
chr2:94963293 (GRCh38.p7) (2q11.1)
AD
GWASdb2
1   publication(s)
See rs on genome
15 Enhancers around
5 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.94963293T>G
GRCh37.p13 chr 2NC_000002.11:g.95629038T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.095G=0.905
1000GenomesAmericanSub694T=0.350G=0.650
1000GenomesEast AsianSub1008T=0.438G=0.562
1000GenomesEuropeSub1006T=0.221G=0.779
1000GenomesGlobalStudy-wide5008T=0.260G=0.740
1000GenomesSouth AsianSub978T=0.270G=0.730
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.231G=0.769
The Genome Aggregation DatabaseAfricanSub8704T=0.105G=0.895
The Genome Aggregation DatabaseAmericanSub820T=0.350G=0.650
The Genome Aggregation DatabaseEast AsianSub1552T=0.511G=0.489
The Genome Aggregation DatabaseEuropeSub18368T=0.210G=0.790
The Genome Aggregation DatabaseGlobalStudy-wide29746T=0.198G=0.801
The Genome Aggregation DatabaseOtherSub302T=0.160G=0.840
Trans-Omics for Precision MedicineGlobalStudy-wide29116T=0.176G=0.823
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.231G=0.769
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs101721673.22E-05alcohol dependence21314694

eQTL of rs10172167 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr2:95629038PROM2ENSG00000155066.11T>G2.7212e-6-311163Frontal_Cortex_BA9
Chr2:95629038CYP4F32PENSG00000223564.1T>G1.6660e-8203014Hypothalamus
Chr2:95629038PROM2ENSG00000155066.11T>G1.2890e-9-311163Cortex
Chr2:95629038PROM2ENSG00000155066.11T>G1.5950e-6-311163Cerebellar_Hemisphere
Chr2:95629038KCNIP3ENSG00000115041.8T>G1.9462e-3-334014Cerebellar_Hemisphere
Chr2:95629038CYP4F32PENSG00000223564.1T>G0.0000e+0203014Caudate_basal_ganglia
Chr2:95629038AC073464.7ENSG00000232502.1T>G2.3907e-11202177Caudate_basal_ganglia
Chr2:95629038CYP4F32PENSG00000223564.1T>G1.0164e-8203014Hippocampus
Chr2:95629038CYP4F32PENSG00000223564.1T>G3.0068e-20203014Putamen_basal_ganglia
Chr2:95629038CYP4F32PENSG00000223564.1T>G8.0216e-24203014Nucleus_accumbens_basal_ganglia
Chr2:95629038AC073464.7ENSG00000232502.1T>G4.3449e-8202177Nucleus_accumbens_basal_ganglia
Chr2:95629038AC073464.11ENSG00000204717.4T>G1.3578e-3156841Nucleus_accumbens_basal_ganglia
Chr2:95629038ANKRD20A8PENSG00000229089.2T>G2.6335e-11106011Nucleus_accumbens_basal_ganglia

meQTL of rs10172167 in Fetal Brain

Probe ID Position Gene beta p-value
cg23064556chr2:95742689-0.0124500339120751.0632e-21

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr29567356095673947E06744522
chr29567412095674296E06745082
chr29567356095673947E06944522
chr29567412095674296E06945082
chr29567642295676464E06947384
chr29567666995676807E06947631
chr29562156595621712E070-7326
chr29562187595621941E070-7097
chr29567356095673947E07144522
chr29567356095673947E07244522
chr29567412095674296E07245082
chr29567436395674417E07245325
chr29567356095673947E07344522
chr29567356095673947E07444522
chr29567412095674296E07445082







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr29566370395664328E06834665
chr29566370395664328E06934665
chr29566370395664328E07134665
chr29566370395664328E07234665
chr29566370395664328E07334665