rs10189905

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0115 (3444/29794,GnomAD)
G=0143 (4176/29118,TOPMED)
G=0129 (644/5008,1000G)
G=0090 (346/3854,ALSPAC)
G=0097 (359/3708,TWINSUK)
chr2:198814386 (GRCh38.p7) (2q33.1)
ND
GWASdb2
2   publication(s)
See rs on genome
11 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.198814386T>G
GRCh37.p13 chr 2NC_000002.11:g.199679110T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.761G=0.239
1000GenomesAmericanSub694T=0.900G=0.100
1000GenomesEast AsianSub1008T=0.912G=0.088
1000GenomesEuropeSub1006T=0.912G=0.088
1000GenomesGlobalStudy-wide5008T=0.871G=0.129
1000GenomesSouth AsianSub978T=0.920G=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.910G=0.090
The Genome Aggregation DatabaseAfricanSub8696T=0.798G=0.202
The Genome Aggregation DatabaseAmericanSub830T=0.900G=0.100
The Genome Aggregation DatabaseEast AsianSub1608T=0.897G=0.103
The Genome Aggregation DatabaseEuropeSub18358T=0.923G=0.076
The Genome Aggregation DatabaseGlobalStudy-wide29794T=0.884G=0.115
The Genome Aggregation DatabaseOtherSub302T=0.880G=0.120
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.856G=0.143
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.903G=0.097
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet
22666496Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.Shiffman DPLoS One

P-Value

SNP ID p-value Traits Study
rs101899052.29E-05alcohol and nictotine co-dependence20158304

eQTL of rs10189905 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10189905 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2199671912199672074E081-7036
chr2199673539199673686E081-5424
chr2199674226199674358E081-4752
chr2199674692199675122E081-3988
chr2199682275199682650E0813165
chr2199683118199683168E0814008
chr2199673539199673686E082-5424
chr2199674226199674358E082-4752
chr2199674692199675122E082-3988
chr2199677302199677359E082-1751
chr2199683118199683168E0824008