rs10202963

Homo sapiens
T>G
TRAK2 : 500B Downstream Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0473 (14149/29878,GnomAD)
G=0488 (14221/29118,TOPMED)
T==0473 (2370/5008,1000G)
T==0411 (1585/3854,ALSPAC)
T==0418 (1550/3708,TWINSUK)
chr2:201377184 (GRCh38.p7) (2q33.1)
AD
GWASdb2
1   publication(s)
See rs on genome
85 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.201377184T>G
GRCh37.p13 chr 2NC_000002.11:g.202241907T>G

Gene: TRAK2, trafficking protein, kinesin binding 2(minus strand): 500B Downstream Variant

Molecule type Change Amino acid[Codon] SO Term
TRAK2 transcriptNM_015049.2:c.N/ADownstream Transcript Variant
TRAK2 transcript variant X1XM_011511690.1:c.N/ADownstream Transcript Variant
TRAK2 transcript variant X2XM_017004772.1:c.N/ADownstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.556G=0.444
1000GenomesAmericanSub694T=0.500G=0.500
1000GenomesEast AsianSub1008T=0.498G=0.502
1000GenomesEuropeSub1006T=0.424G=0.576
1000GenomesGlobalStudy-wide5008T=0.473G=0.527
1000GenomesSouth AsianSub978T=0.370G=0.630
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.411G=0.589
The Genome Aggregation DatabaseAfricanSub8684T=0.578G=0.422
The Genome Aggregation DatabaseAmericanSub834T=0.500G=0.500
The Genome Aggregation DatabaseEast AsianSub1614T=0.478G=0.522
The Genome Aggregation DatabaseEuropeSub18444T=0.421G=0.578
The Genome Aggregation DatabaseGlobalStudy-wide29878T=0.473G=0.526
The Genome Aggregation DatabaseOtherSub302T=0.530G=0.470
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.511G=0.488
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.418G=0.582
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs102029630.00086alcohol dependence20201924

eQTL of rs10202963 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr2:202241907CASP8ENSG00000064012.17T>G1.1692e-16143741Cerebellum
Chr2:202241907CASP8ENSG00000064012.17T>G6.4882e-11143741Frontal_Cortex_BA9
Chr2:202241907CASP8ENSG00000064012.17T>G1.3634e-11143741Cortex
Chr2:202241907CASP8ENSG00000064012.17T>G3.9218e-19143741Cerebellar_Hemisphere
Chr2:202241907STRADBENSG00000082146.8T>G3.8054e-4-10818Substantia_nigra

meQTL of rs10202963 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2202270900202271593E06728993
chr2202278304202278654E06736397
chr2202278747202279500E06736840
chr2202279865202279962E06737958
chr2202227603202227687E068-14220
chr2202268714202268952E06826807
chr2202269362202269420E06827455
chr2202269574202269778E06827667
chr2202277882202277992E06835975
chr2202278036202278191E06836129
chr2202278304202278654E06836397
chr2202278747202279500E06836840
chr2202284781202285095E06842874
chr2202285136202285724E06843229
chr2202288938202288978E06847031
chr2202289243202289310E06847336
chr2202289646202289851E06847739
chr2202289986202290026E06848079
chr2202268576202268691E06926669
chr2202268714202268952E06926807
chr2202270900202271593E06928993
chr2202271707202271761E06929800
chr2202271892202272333E06929985
chr2202278036202278191E06936129
chr2202278304202278654E06936397
chr2202278747202279500E06936840
chr2202279865202279962E06937958
chr2202280080202280209E06938173
chr2202280310202280361E06938403
chr2202283828202284121E06941921
chr2202284781202285095E06942874
chr2202285136202285724E06943229
chr2202285739202285993E06943832
chr2202286027202286077E06944120
chr2202286083202286174E06944176
chr2202286183202286279E06944276
chr2202289243202289310E06947336
chr2202268576202268691E07026669
chr2202268714202268952E07026807
chr2202271707202271761E07029800
chr2202288938202288978E07047031
chr2202267592202267936E07125685
chr2202268052202268213E07126145
chr2202268576202268691E07126669
chr2202268714202268952E07126807
chr2202270900202271593E07128993
chr2202271707202271761E07129800
chr2202271892202272333E07129985
chr2202277882202277992E07135975
chr2202278036202278191E07136129
chr2202278304202278654E07136397
chr2202278747202279500E07136840
chr2202279865202279962E07137958
chr2202289243202289310E07147336
chr2202289646202289851E07147739
chr2202270900202271593E07228993
chr2202271707202271761E07229800
chr2202271892202272333E07229985
chr2202277882202277992E07235975
chr2202278036202278191E07236129
chr2202278304202278654E07236397
chr2202278747202279500E07236840
chr2202288938202288978E07247031
chr2202289243202289310E07247336
chr2202289646202289851E07247739
chr2202289986202290026E07248079
chr2202270900202271593E07328993
chr2202278036202278191E07336129
chr2202278304202278654E07336397
chr2202278747202279500E07336840
chr2202279865202279962E07337958
chr2202270900202271593E07428993
chr2202271707202271761E07429800
chr2202271892202272333E07429985
chr2202278036202278191E07436129
chr2202278304202278654E07436397
chr2202278747202279500E07436840
chr2202279865202279962E07437958
chr2202280080202280209E07438173
chr2202289243202289310E07447336
chr2202287407202287461E08145500
chr2202287488202287574E08145581
chr2202287697202287741E08145790
chr2202287806202287875E08145899
chr2202270900202271593E08228993