rs10223341

Homo sapiens
G>T
SAMD3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0057 (1737/29980,GnomAD)
T=0045 (1318/29118,TOPMED)
T=0037 (186/5008,1000G)
T=0070 (268/3854,ALSPAC)
T=0079 (294/3708,TWINSUK)
chr6:130174738 (GRCh38.p7) (6q23.1)
OD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.130174738G>T
GRCh37.p13 chr 6NC_000006.11:g.130495883G>T

Gene: SAMD3, sterile alpha motif domain containing 3(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SAMD3 transcript variant 1NM_001017373.3:c.N/AIntron Variant
SAMD3 transcript variant 3NM_001258275.2:c.N/AIntron Variant
SAMD3 transcript variant 4NM_001277185.1:c.N/AIntron Variant
SAMD3 transcript variant X6XM_017010305.1:c.N/AIntron Variant
SAMD3 transcript variant X6XM_017010306.1:c.N/AIntron Variant
SAMD3 transcript variant X11XM_017010307.1:c.N/AIntron Variant
SAMD3 transcript variant X8XM_017010308.1:c.N/AIntron Variant
SAMD3 transcript variant X9XM_017010309.1:c.N/AGenic Downstream Transcript Variant
SAMD3 transcript variant X10XM_017010310.1:c.N/AGenic Downstream Transcript Variant
SAMD3 transcript variant X1XR_001743171.1:n.N/AIntron Variant
SAMD3 transcript variant X2XR_001743172.1:n.N/AIntron Variant
SAMD3 transcript variant X3XR_001743173.1:n.N/AIntron Variant
SAMD3 transcript variant X4XR_001743174.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.966T=0.034
1000GenomesAmericanSub694G=0.960T=0.040
1000GenomesEast AsianSub1008G=0.996T=0.004
1000GenomesEuropeSub1006G=0.924T=0.076
1000GenomesGlobalStudy-wide5008G=0.963T=0.037
1000GenomesSouth AsianSub978G=0.960T=0.040
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.930T=0.070
The Genome Aggregation DatabaseAfricanSub8730G=0.964T=0.036
The Genome Aggregation DatabaseAmericanSub838G=0.980T=0.020
The Genome Aggregation DatabaseEast AsianSub1622G=0.991T=0.009
The Genome Aggregation DatabaseEuropeSub18488G=0.925T=0.074
The Genome Aggregation DatabaseGlobalStudy-wide29980G=0.942T=0.057
The Genome Aggregation DatabaseOtherSub302G=0.970T=0.030
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.954T=0.045
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.921T=0.079
PMID Title Author Journal
23183491Genome-wide association study identifies a potent locus associated with human opioid sensitivity.Nishizawa DMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs102233413.72E-05Opioid sensitivity23183491

eQTL of rs10223341 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10223341 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6130481109130481521E081-14362
chr6130455755130456062E082-39821