SNP Detail Info-rs10224675

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 7	NC_000007.14:g.144595669A>G
GRCh37.p13 chr 7	NC_000007.13:g.144292762A>G
TPK1 RefSeqGene	NG_032112.1:g.245385T>C

Gene: TPK1, thiamin pyrophosphokinase 1(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
TPK1 transcript variant 2	NM_001042482.1:c.	N/A	Intron Variant
TPK1 transcript variant 1	NM_022445.3:c.	N/A	Intron Variant
TPK1 transcript variant X11	XM_005249970.1:c.	N/A	Intron Variant
TPK1 transcript variant X1	XM_011516031.1:c.	N/A	Intron Variant
TPK1 transcript variant X3	XM_011516032.2:c.	N/A	Intron Variant
TPK1 transcript variant X2	XM_011516033.2:c.	N/A	Intron Variant
TPK1 transcript variant X4	XM_011516034.2:c.	N/A	Intron Variant
TPK1 transcript variant X7	XM_011516035.2:c.	N/A	Intron Variant
TPK1 transcript variant X8	XM_011516037.2:c.	N/A	Intron Variant
TPK1 transcript variant X13	XM_011516039.2:c.	N/A	Intron Variant
TPK1 transcript variant X15	XM_011516040.2:c.	N/A	Intron Variant
TPK1 transcript variant X21	XM_011516041.2:c.	N/A	Intron Variant
TPK1 transcript variant X16	XM_011516043.1:c.	N/A	Intron Variant
TPK1 transcript variant X25	XM_011516044.1:c.	N/A	Intron Variant
TPK1 transcript variant X24	XM_011516047.2:c.	N/A	Intron Variant
TPK1 transcript variant X23	XM_011516048.1:c.	N/A	Intron Variant
TPK1 transcript variant X37	XM_011516050.1:c.	N/A	Intron Variant
TPK1 transcript variant X5	XM_017011969.1:c.	N/A	Intron Variant
TPK1 transcript variant X7	XM_017011970.1:c.	N/A	Intron Variant
TPK1 transcript variant X9	XM_017011971.1:c.	N/A	Intron Variant
TPK1 transcript variant X10	XM_017011972.1:c.	N/A	Intron Variant
TPK1 transcript variant X12	XM_017011973.1:c.	N/A	Intron Variant
TPK1 transcript variant X12	XM_017011974.1:c.	N/A	Intron Variant
TPK1 transcript variant X14	XM_017011975.1:c.	N/A	Intron Variant
TPK1 transcript variant X18	XM_017011976.1:c.	N/A	Intron Variant
TPK1 transcript variant X19	XM_017011977.1:c.	N/A	Intron Variant
TPK1 transcript variant X20	XM_017011978.1:c.	N/A	Intron Variant
TPK1 transcript variant X24	XM_017011979.1:c.	N/A	Intron Variant
TPK1 transcript variant X26	XM_017011980.1:c.	N/A	Intron Variant
TPK1 transcript variant X27	XM_017011981.1:c.	N/A	Intron Variant
TPK1 transcript variant X22	XM_017011982.1:c.	N/A	Intron Variant
TPK1 transcript variant X30	XM_017011983.1:c.	N/A	Intron Variant
TPK1 transcript variant X31	XM_017011984.1:c.	N/A	Intron Variant
TPK1 transcript variant X34	XM_017011985.1:c.	N/A	Intron Variant
TPK1 transcript variant X36	XM_017011986.1:c.	N/A	Intron Variant
TPK1 transcript variant X21	XM_011516046.1:c.	N/A	Genic Downstream Transcript Variant
TPK1 transcript variant X17	XR_001744630.1:n.	N/A	Intron Variant
TPK1 transcript variant X6	XR_927446.2:n.	N/A	Intron Variant
TPK1 transcript variant X35	XR_927453.1:n.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.900	G=0.100
1000Genomes	American	Sub	694	A=0.990	G=0.010
1000Genomes	East Asian	Sub	1008	A=1.000	G=0.000
1000Genomes	Europe	Sub	1006	A=0.999	G=0.001
1000Genomes	Global	Study-wide	5008	A=0.973	G=0.027
1000Genomes	South Asian	Sub	978	A=1.000	G=0.000
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=1.000	G=0.000
The Genome Aggregation Database	African	Sub	8706	A=0.911	G=0.089
The Genome Aggregation Database	American	Sub	836	A=0.990	G=0.010
The Genome Aggregation Database	East Asian	Sub	1620	A=1.000	G=0.000
The Genome Aggregation Database	Europe	Sub	18398	A=0.999	G=0.000
The Genome Aggregation Database	Global	Study-wide	29862	A=0.973	G=0.026
The Genome Aggregation Database	Other	Sub	302	A=1.000	G=0.000
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.963	G=0.036
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.999	G=0.001

PMID	Title	Author	Journal
20202923	A genome-wide association study of alcohol dependence.	Bierut LJ	Proc Natl Acad Sci U S A
21956439	Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.	Zuo L	Neuropsychopharmacology

P-Value

SNP ID	p-value	Traits	Study
rs10224675	3.8E-05	alcohol dependence	21956439

eQTL of rs10224675 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10224675 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

rs10224675

Genomic Coordinates

Gene: TPK1, thiamin pyrophosphokinase 1(minus strand)

Population Frequency

P-Value

eQTL of rs10224675 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs10224675 in Fetal Brain

Genomic View

Chromatin Interaction