rs10227063

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0360 (10715/29708,GnomAD)
G=0337 (9823/29118,TOPMED)
G=0293 (1467/5008,1000G)
G=0345 (1330/3854,ALSPAC)
G=0362 (1341/3708,TWINSUK)
chr7:121635423 (GRCh38.p7) (7q31.32)
AD
GWASdb2
1   publication(s)
See rs on genome
56 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.121635423A>G
GRCh37.p13 chr 7NC_000007.13:g.121275477A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.618G=0.382
1000GenomesAmericanSub694A=0.670G=0.330
1000GenomesEast AsianSub1008A=0.893G=0.107
1000GenomesEuropeSub1006A=0.641G=0.359
1000GenomesGlobalStudy-wide5008A=0.707G=0.293
1000GenomesSouth AsianSub978A=0.730G=0.270
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.655G=0.345
The Genome Aggregation DatabaseAfricanSub8566A=0.634G=0.366
The Genome Aggregation DatabaseAmericanSub834A=0.700G=0.300
The Genome Aggregation DatabaseEast AsianSub1594A=0.891G=0.109
The Genome Aggregation DatabaseEuropeSub18412A=0.616G=0.383
The Genome Aggregation DatabaseGlobalStudy-wide29708A=0.639G=0.360
The Genome Aggregation DatabaseOtherSub302A=0.700G=0.300
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.662G=0.337
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.638G=0.362
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs102270635.2E-05alcoholism (heaviness of drinking)21529783

eQTL of rs10227063 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10227063 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7121316481121316609E07041004
chr7121317220121317312E07041743
chr7121317531121317685E07042054
chr7121245809121245860E071-29617
chr7121245974121246116E071-29361
chr7121265098121265509E071-9968
chr7121260392121260570E074-14907
chr7121234630121234680E081-40797
chr7121235500121235607E081-39870
chr7121235657121236780E081-38697
chr7121237168121237315E081-38162
chr7121237457121237526E081-37951
chr7121241605121241655E081-33822
chr7121241864121242290E081-33187
chr7121242360121242426E081-33051
chr7121242448121242515E081-32962
chr7121242584121242750E081-32727
chr7121242961121243011E081-32466
chr7121243124121243197E081-32280
chr7121243575121243756E081-31721
chr7121243846121243896E081-31581
chr7121244059121244274E081-31203
chr7121244400121245784E081-29693
chr7121245809121245860E081-29617
chr7121245974121246116E081-29361
chr7121247936121248062E081-27415
chr7121248157121248541E081-26936
chr7121248900121249124E081-26353
chr7121249351121249488E081-25989
chr7121250007121250121E081-25356
chr7121250143121250249E081-25228
chr7121260392121260570E081-14907
chr7121260582121260885E081-14592
chr7121260909121261498E081-13979
chr7121261627121261937E081-13540
chr7121264892121264942E081-10535
chr7121241605121241655E082-33822
chr7121241864121242290E082-33187
chr7121242360121242426E082-33051
chr7121242448121242515E082-32962
chr7121242584121242750E082-32727
chr7121243846121243896E082-31581
chr7121244059121244274E082-31203
chr7121244400121245784E082-29693
chr7121245809121245860E082-29617
chr7121245974121246116E082-29361
chr7121247936121248062E082-27415
chr7121248157121248541E082-26936
chr7121248900121249124E082-26353
chr7121249351121249488E082-25989
chr7121250007121250121E082-25356
chr7121250143121250249E082-25228
chr7121263086121263137E082-12340
chr7121263230121263469E082-12008
chr7121263593121263776E082-11701
chr7121265861121265951E082-9526