rs10229281

Homo sapiens
G>A
FAM188B : Intron Variant
INMT-FAM188B : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0145 (4342/29918,GnomAD)
A=0159 (4634/29118,TOPMED)
A=0233 (1169/5008,1000G)
A=0095 (368/3854,ALSPAC)
A=0097 (358/3708,TWINSUK)
chr7:30837026 (GRCh38.p7) (7p14.3)
ND
GWASdb2
1   publication(s)
See rs on genome
129 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.30837026G>A
GRCh37.p13 chr 7NC_000007.13:g.30876642G>A

Gene: FAM188B, family with sequence similarity 188 member B(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MINDY4 transcriptNM_032222.2:c.N/AIntron Variant

Gene: INMT-FAM188B, INMT-FAM188B readthrough (NMD candidate)(plus strand)

Molecule type Change Amino acid[Codon] SO Term
INMT-MINDY4 transcriptNR_037598.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.711A=0.289
1000GenomesAmericanSub694G=0.890A=0.110
1000GenomesEast AsianSub1008G=0.612A=0.388
1000GenomesEuropeSub1006G=0.910A=0.090
1000GenomesGlobalStudy-wide5008G=0.767A=0.233
1000GenomesSouth AsianSub978G=0.770A=0.230
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.905A=0.095
The Genome Aggregation DatabaseAfricanSub8690G=0.755A=0.245
The Genome Aggregation DatabaseAmericanSub838G=0.920A=0.080
The Genome Aggregation DatabaseEast AsianSub1618G=0.625A=0.375
The Genome Aggregation DatabaseEuropeSub18472G=0.919A=0.080
The Genome Aggregation DatabaseGlobalStudy-wide29918G=0.854A=0.145
The Genome Aggregation DatabaseOtherSub300G=0.850A=0.150
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.840A=0.159
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.903A=0.097
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs102292812.85E-05alcohol and nictotine co-dependence20158304

eQTL of rs10229281 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10229281 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr73084518730845296E067-31346
chr73084530930845359E067-31283
chr73088517930885782E0678537
chr73090269630903894E06726054
chr73090391530904113E06727273
chr73090411530904194E06727473
chr73084334730843516E068-33126
chr73084518730845296E068-31346
chr73084530930845359E068-31283
chr73085443030854995E068-21647
chr73085503630855501E068-21141
chr73088207130882121E0685429
chr73088234730882430E0685705
chr73088251930882576E0685877
chr73088264230882947E0686000
chr73088298230883036E0686340
chr73088308030883170E0686438
chr73088339030883484E0686748
chr73088383730883921E0687195
chr73088418330884233E0687541
chr73088517930885782E0688537
chr73088578430886420E0689142
chr73088681130886883E06810169
chr73088692230887012E06810280
chr73090269630903894E06826054
chr73090391530904113E06827273
chr73090411530904194E06827473
chr73091873530918785E06842093
chr73091883730918930E06842195
chr73091896330919299E06842321
chr73091945530919509E06842813
chr73091966330920531E06843021
chr73092053830920593E06843896
chr73092060030920891E06843958
chr73092095730921138E06844315
chr73092118030921230E06844538
chr73092123830921359E06844596
chr73083893930841063E069-35579
chr73085503630855501E069-21141
chr73090269630903894E06926054
chr73090391530904113E06927273
chr73090411530904194E06927473
chr73090948530910379E06932843
chr73090909930909200E07032457
chr73090933430909399E07032692
chr73090948530910379E07032843
chr73084518730845296E071-31346
chr73084530930845359E071-31283
chr73084540830846218E071-30424
chr73087917130879258E0712529
chr73087935730879407E0712715
chr73087949330879543E0712851
chr73087962630879682E0712984
chr73087975930879809E0713117
chr73087981330879925E0713171
chr73088207130882121E0715429
chr73088234730882430E0715705
chr73088251930882576E0715877
chr73088264230882947E0716000
chr73088298230883036E0716340
chr73088308030883170E0716438
chr73088339030883484E0716748
chr73088517930885782E0718537
chr73088578430886420E0719142
chr73090188330902082E07125241
chr73090220130902251E07125559
chr73090239030902455E07125748
chr73090269630903894E07126054
chr73090391530904113E07127273
chr73090411530904194E07127473
chr73085443030854995E072-21647
chr73085503630855501E072-21141
chr73087902330879109E0722381
chr73087917130879258E0722529
chr73088517930885782E0728537
chr73090269630903894E07226054
chr73090391530904113E07227273
chr73090411530904194E07227473
chr73090466430905262E07228022
chr73084530930845359E073-31283
chr73085443030854995E073-21647
chr73085503630855501E073-21141
chr73085550830857271E073-19371
chr73088578430886420E0739142
chr73088681130886883E07310169
chr73090269630903894E07326054
chr73090391530904113E07327273
chr73090411530904194E07327473
chr73084442330844640E074-32002
chr73084471230844841E074-31801
chr73084506530845115E074-31527
chr73084518730845296E074-31346
chr73084530930845359E074-31283
chr73084540830846218E074-30424
chr73085503630855501E074-21141
chr73087853030878608E0741888
chr73087861930878704E0741977
chr73087892730878977E0742285
chr73087902330879109E0742381
chr73087917130879258E0742529
chr73087935730879407E0742715
chr73087949330879543E0742851
chr73088517930885782E0748537
chr73088578430886420E0749142
chr73090269630903894E07426054
chr73090391530904113E07427273
chr73090411530904194E07427473
chr73090188330902082E08125241
chr73090220130902251E08125559
chr73090239030902455E08125748
chr73090269630903894E08126054
chr73090864330908693E08132001
chr73090872230908782E08132080
chr73090909930909200E08132457
chr73090933430909399E08132692
chr73090948530910379E08132843
chr73091052030910580E08133878
chr73091061930910669E08133977
chr73091070630910756E08134064
chr73091087930910939E08134237
chr73091105830911108E08134416
chr73090088530900985E08224243
chr73090909930909200E08232457
chr73090933430909399E08232692
chr73090948530910379E08232843
chr73091052030910580E08233878
chr73091061930910669E08233977
chr73091070630910756E08234064
chr73091087930910939E08234237