rs10256873

Organism: Homo sapiens

Alleles: G>A / G>C

Gene : Feature

GRM8 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0490 (14647/29884,GnomAD)
G==0485 (14132/29118,TOPMED)
A=0461 (2308/5008,1000G)
A=0367 (1415/3854,ALSPAC)
A=0369 (1370/3708,TWINSUK)

Position: chr7:126728238 (GRCh38.p7) (7q31.33)

Phenotype: AD

Dataset:

GWASdb2

Publications: 2 publication(s)

Genomic View: See rs on genome

Enhancer: 9 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 7	NC_000007.14:g.126728238G>A
GRCh38.p7 chr 7	NC_000007.14:g.126728238G>C
GRCh37.p13 chr 7	NC_000007.13:g.126368292G>A
GRCh37.p13 chr 7	NC_000007.13:g.126368292G>C
GRM8 RefSeqGene	NG_029532.1:g.529137C>T
GRM8 RefSeqGene	NG_029532.1:g.529137C>G

Gene: GRM8, glutamate metabotropic receptor 8(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
GRM8 transcript variant 1	NM_000845.2:c.	N/A	Intron Variant
GRM8 transcript variant 2	NM_001127323.1:c.	N/A	Intron Variant
GRM8 transcript variant 3	NR_028041.1:n.	N/A	Intron Variant
GRM8 transcript variant X2	XM_006715938.3:c.	N/A	Intron Variant
GRM8 transcript variant X1	XM_011516091.1:c.	N/A	Intron Variant
GRM8 transcript variant X3	XM_011516092.2:c.	N/A	Intron Variant
GRM8 transcript variant X5	XM_011516094.1:c.	N/A	Intron Variant
GRM8 transcript variant X6	XM_011516095.2:c.	N/A	Intron Variant
GRM8 transcript variant X12	XM_011516101.2:c.	N/A	Intron Variant
GRM8 transcript variant X13	XM_011516102.2:c.	N/A	Intron Variant
GRM8 transcript variant X14	XM_011516103.2:c.	N/A	Intron Variant
GRM8 transcript variant X17	XM_011516108.2:c.	N/A	Intron Variant
GRM8 transcript variant X4	XM_017012074.1:c.	N/A	Intron Variant
GRM8 transcript variant X7	XM_017012075.1:c.	N/A	Intron Variant
GRM8 transcript variant X8	XM_017012076.1:c.	N/A	Intron Variant
GRM8 transcript variant X9	XM_017012077.1:c.	N/A	Intron Variant
GRM8 transcript variant X10	XM_017012078.1:c.	N/A	Intron Variant
GRM8 transcript variant X11	XM_017012079.1:c.	N/A	Intron Variant
GRM8 transcript variant X15	XM_017012080.1:c.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.292	A=0.708
1000Genomes	American	Sub	694	G=0.650	A=0.350
1000Genomes	East Asian	Sub	1008	G=0.631	A=0.369
1000Genomes	Europe	Sub	1006	G=0.605	A=0.395
1000Genomes	Global	Study-wide	5008	G=0.539	A=0.461
1000Genomes	South Asian	Sub	978	G=0.630	A=0.370
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.633	A=0.367
The Genome Aggregation Database	African	Sub	8714	G=0.321	C=0.000
The Genome Aggregation Database	American	Sub	838	G=0.590	C=0.00,
The Genome Aggregation Database	East Asian	Sub	1592	G=0.622	C=0.000
The Genome Aggregation Database	Europe	Sub	18438	G=0.583	C=0.000
The Genome Aggregation Database	Global	Study-wide	29884	G=0.509	C=0.000
The Genome Aggregation Database	Other	Sub	302	G=0.660	C=0.00,
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.485	A=0.514
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.631	A=0.369

PMID	Title	Author	Journal
21314694	Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	Kendler KS	Alcohol Clin Exp Res
18618593	Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.	Chen AC	Am J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID	p-value	Traits	Study
rs10256873	0.000914	alcohol dependence	21314694

eQTL of rs10256873 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10256873 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr7	85260203	85260713	E067	19957
chr7	85260203	85260713	E069	19957
chr7	85260732	85260829	E069	20486
chr7	85230407	85230492	E071	-9754
chr7	85230576	85230703	E071	-9543
chr7	85260203	85260713	E071	19957
chr7	85260732	85260829	E071	20486
chr7	85260203	85260713	E074	19957
chr7	85260732	85260829	E074	20486