rs10274025

Homo sapiens
G>A
DPP6 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0134 (4026/29964,GnomAD)
A=0175 (5109/29118,TOPMED)
A=0150 (753/5008,1000G)
A=0095 (366/3854,ALSPAC)
A=0094 (348/3708,TWINSUK)
chr7:154270195 (GRCh38.p7) (7q36.2)
ND
GWASdb2
1   publication(s)
See rs on genome
60 Enhancers around
60 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.154270195G>A
GRCh37.p13 chr 7NC_000007.13:g.153967280G>A
DPP6 RefSeqGeneNG_033878.1:g.387862G>A

Gene: DPP6, dipeptidyl peptidase like 6(plus strand)

Molecule type Change Amino acid[Codon] SO Term
DPP6 transcript variant 3NM_001039350.2:c.N/AIntron Variant
DPP6 transcript variant 5NM_001290253.1:c.N/AIntron Variant
DPP6 transcript variant 1NM_130797.3:c.N/AIntron Variant
DPP6 transcript variant 4NM_001290252.1:c.N/AGenic Upstream Transcript Variant
DPP6 transcript variant 2NM_001936.4:c.N/AGenic Upstream Transcript Variant
DPP6 transcript variant X1XM_017011808.1:c.N/AIntron Variant
DPP6 transcript variant X2XM_017011809.1:c.N/AIntron Variant
DPP6 transcript variant X3XM_017011810.1:c.N/AIntron Variant
DPP6 transcript variant X4XM_017011811.1:c.N/AIntron Variant
DPP6 transcript variant X5XM_017011812.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.705A=0.295
1000GenomesAmericanSub694G=0.900A=0.100
1000GenomesEast AsianSub1008G=0.941A=0.059
1000GenomesEuropeSub1006G=0.907A=0.093
1000GenomesGlobalStudy-wide5008G=0.850A=0.150
1000GenomesSouth AsianSub978G=0.850A=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.905A=0.095
The Genome Aggregation DatabaseAfricanSub8712G=0.726A=0.274
The Genome Aggregation DatabaseAmericanSub838G=0.890A=0.110
The Genome Aggregation DatabaseEast AsianSub1614G=0.937A=0.063
The Genome Aggregation DatabaseEuropeSub18498G=0.923A=0.076
The Genome Aggregation DatabaseGlobalStudy-wide29964G=0.865A=0.134
The Genome Aggregation DatabaseOtherSub302G=0.890A=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.824A=0.175
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.906A=0.094
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs102740251.85E-05alcohol and nictotine co-dependence20158304

eQTL of rs10274025 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10274025 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7153934779153934847E067-32433
chr7153935082153935289E067-31991
chr7154001437154001516E06734157
chr7154001546154001627E06734266
chr7154007370154007439E06740090
chr7153952213153952735E068-14545
chr7153952768153952826E068-14454
chr7153970962153971156E0683682
chr7154001437154001516E06834157
chr7154001546154001627E06834266
chr7154007370154007439E06840090
chr7154007770154008020E06840490
chr7154001437154001516E06934157
chr7154001546154001627E06934266
chr7154007370154007439E06940090
chr7154007770154008020E06940490
chr7154001437154001516E07034157
chr7154001546154001627E07034266
chr7154007770154008020E07040490
chr7153952213153952735E071-14545
chr7153952768153952826E071-14454
chr7154001437154001516E07134157
chr7154007370154007439E07140090
chr7153952213153952735E072-14545
chr7153952768153952826E072-14454
chr7154001437154001516E07234157
chr7154001546154001627E07234266
chr7154007370154007439E07240090
chr7154007770154008020E07240490
chr7154001437154001516E07334157
chr7154001546154001627E07334266
chr7153975019153975069E0747739
chr7153975287153975347E0748007
chr7154001437154001516E07434157
chr7154001546154001627E07434266
chr7154007370154007439E07440090
chr7154007770154008020E07440490
chr7153928759153928921E081-38359
chr7153928962153929121E081-38159
chr7153929152153929333E081-37947
chr7153929716153929776E081-37504
chr7153929795153930431E081-36849
chr7153949378153949428E081-17852
chr7153949767153950024E081-17256
chr7153950190153950265E081-17015
chr7153950301153950461E081-16819
chr7153950947153951071E081-16209
chr7153970962153971156E0813682
chr7153971576153971674E0814296
chr7153971715153971858E0814435
chr7153971919153971969E0814639
chr7153972324153972414E0815044
chr7154001437154001516E08134157
chr7154001546154001627E08134266
chr7154005918154006308E08138638
chr7154007370154007439E08140090
chr7154007770154008020E08140490
chr7154009772154009822E08142492
chr7153970962153971156E0823682
chr7154007370154007439E08240090










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr7154001754154002123E06734474
chr7154002155154002441E06734875
chr7154002496154002723E06735216
chr7154002774154003090E06735494
chr7154003157154003260E06735877
chr7154003480154003715E06736200
chr7154001754154002123E06834474
chr7154002155154002441E06834875
chr7154002496154002723E06835216
chr7154002774154003090E06835494
chr7154003157154003260E06835877
chr7154003480154003715E06836200
chr7154004461154004529E06837181
chr7154005039154005089E06837759
chr7154001754154002123E06934474
chr7154002155154002441E06934875
chr7154002496154002723E06935216
chr7154002774154003090E06935494
chr7154003157154003260E06935877
chr7154003480154003715E06936200
chr7154001754154002123E07034474
chr7154002155154002441E07034875
chr7154003480154003715E07036200
chr7154001754154002123E07134474
chr7154002155154002441E07134875
chr7154002496154002723E07135216
chr7154002774154003090E07135494
chr7154003157154003260E07135877
chr7154003480154003715E07136200
chr7154004461154004529E07137181
chr7154002155154002441E07234875
chr7154002496154002723E07235216
chr7154002774154003090E07235494
chr7154003157154003260E07235877
chr7154003480154003715E07236200
chr7154004461154004529E07237181
chr7154005039154005089E07237759
chr7154001754154002123E07334474
chr7154002155154002441E07334875
chr7154002496154002723E07335216
chr7154002774154003090E07335494
chr7154003157154003260E07335877
chr7154003480154003715E07336200
chr7154004461154004529E07337181
chr7154005039154005089E07337759
chr7154002155154002441E07434875
chr7154002496154002723E07435216
chr7154002774154003090E07435494
chr7154002155154002441E08134875
chr7154002496154002723E08135216
chr7154002774154003090E08135494
chr7154003157154003260E08135877
chr7154001754154002123E08234474
chr7154002155154002441E08234875
chr7154002496154002723E08235216
chr7154002774154003090E08235494
chr7154003157154003260E08235877
chr7154003480154003715E08236200
chr7154004461154004529E08237181
chr7154005039154005089E08237759