rs10277421

Homo sapiens
T>C
PLXNA4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0307 (9209/29930,GnomAD)
T==0259 (7551/29118,TOPMED)
T==0206 (1033/5008,1000G)
T==0407 (1568/3854,ALSPAC)
T==0411 (1523/3708,TWINSUK)
chr7:132174318 (GRCh38.p7) (7q32.3)
AD
GWASdb2
1   publication(s)
See rs on genome
125 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.132174318T>C
GRCh37.p13 chr 7NC_000007.13:g.131859077T>C

Gene: PLXNA4, plexin A4(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PLXNA4 transcript variant 1NM_020911.1:c.N/AIntron Variant
PLXNA4 transcript variant 3NM_001105543.1:c.N/AGenic Downstream Transcript Variant
PLXNA4 transcript variant 2NM_181775.3:c.N/AGenic Downstream Transcript Variant
PLXNA4 transcript variant X2XM_005250686.4:c.N/AIntron Variant
PLXNA4 transcript variant X1XM_006716171.3:c.N/AIntron Variant
PLXNA4 transcript variant X4XM_011516676.2:c.N/AIntron Variant
PLXNA4 transcript variant X3XM_017012779.1:c.N/AIntron Variant
PLXNA4 transcript variant X5XR_927546.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.021C=0.979
1000GenomesAmericanSub694T=0.280C=0.720
1000GenomesEast AsianSub1008T=0.307C=0.693
1000GenomesEuropeSub1006T=0.391C=0.609
1000GenomesGlobalStudy-wide5008T=0.206C=0.794
1000GenomesSouth AsianSub978T=0.110C=0.890
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.407C=0.593
The Genome Aggregation DatabaseAfricanSub8718T=0.078C=0.922
The Genome Aggregation DatabaseAmericanSub838T=0.340C=0.660
The Genome Aggregation DatabaseEast AsianSub1622T=0.302C=0.698
The Genome Aggregation DatabaseEuropeSub18450T=0.416C=0.584
The Genome Aggregation DatabaseGlobalStudy-wide29930T=0.307C=0.692
The Genome Aggregation DatabaseOtherSub302T=0.280C=0.720
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.259C=0.740
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.411C=0.589
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs102774218.45E-05alcohol consumption23743675

eQTL of rs10277421 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10277421 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7131824892131825282E067-33795
chr7131825393131825569E067-33508
chr7131829948131830001E067-29076
chr7131830013131830097E067-28980
chr7131830162131830629E067-28448
chr7131836810131837186E067-21891
chr7131845356131846405E067-12672
chr7131861840131862016E0682763
chr7131862056131862145E0682979
chr7131875288131875338E06816211
chr7131875472131875566E06816395
chr7131829948131830001E069-29076
chr7131830013131830097E069-28980
chr7131830162131830629E069-28448
chr7131845356131846405E069-12672
chr7131845356131846405E070-12672
chr7131846926131847325E070-11752
chr7131847370131847868E070-11209
chr7131861697131861776E0702620
chr7131861840131862016E0702763
chr7131862056131862145E0702979
chr7131862195131862862E0703118
chr7131862938131863000E0703861
chr7131863053131863194E0703976
chr7131863195131863433E0704118
chr7131899000131899050E07039923
chr7131899054131899270E07039977
chr7131845356131846405E071-12672
chr7131829858131829944E072-29133
chr7131829948131830001E072-29076
chr7131830162131830629E072-28448
chr7131837670131837720E072-21357
chr7131845356131846405E072-12672
chr7131846926131847325E072-11752
chr7131825393131825569E073-33508
chr7131845356131846405E074-12672
chr7131809077131809131E081-49946
chr7131825393131825569E081-33508
chr7131825941131826221E081-32856
chr7131826797131826848E081-32229
chr7131826927131827042E081-32035
chr7131827477131827531E081-31546
chr7131827611131827745E081-31332
chr7131828076131828184E081-30893
chr7131828621131828674E081-30403
chr7131828790131828856E081-30221
chr7131828922131828972E081-30105
chr7131829260131829340E081-29737
chr7131829351131829401E081-29676
chr7131829662131829790E081-29287
chr7131829858131829944E081-29133
chr7131829948131830001E081-29076
chr7131834103131834532E081-24545
chr7131834788131834895E081-24182
chr7131835168131835257E081-23820
chr7131835358131835421E081-23656
chr7131840708131840810E081-18267
chr7131840979131841097E081-17980
chr7131841344131841420E081-17657
chr7131842565131842615E081-16462
chr7131842745131842825E081-16252
chr7131842846131842896E081-16181
chr7131842969131843244E081-15833
chr7131843356131843477E081-15600
chr7131843791131843867E081-15210
chr7131845086131845126E081-13951
chr7131845356131846405E081-12672
chr7131846450131846564E081-12513
chr7131846592131846827E081-12250
chr7131846926131847325E081-11752
chr7131847370131847868E081-11209
chr7131847937131847991E081-11086
chr7131848242131848322E081-10755
chr7131848540131848590E081-10487
chr7131848628131848718E081-10359
chr7131848848131849019E081-10058
chr7131849242131849292E081-9785
chr7131849342131849477E081-9600
chr7131860522131860572E0811445
chr7131862056131862145E0812979
chr7131862195131862862E0813118
chr7131862938131863000E0813861
chr7131863053131863194E0813976
chr7131863195131863433E0814118
chr7131863522131863576E0814445
chr7131863673131863813E0814596
chr7131863841131864073E0814764
chr7131864312131864449E0815235
chr7131867569131867669E0818492
chr7131867684131867734E0818607
chr7131867776131868096E0818699
chr7131868144131868184E0819067
chr7131868245131868843E0819168
chr7131868880131869103E0819803
chr7131809077131809131E082-49946
chr7131825941131826221E082-32856
chr7131826797131826848E082-32229
chr7131828790131828856E082-30221
chr7131828922131828972E082-30105
chr7131829260131829340E082-29737
chr7131829351131829401E082-29676
chr7131829662131829790E082-29287
chr7131829858131829944E082-29133
chr7131829948131830001E082-29076
chr7131834788131834895E082-24182
chr7131839415131839463E082-19614
chr7131839564131839735E082-19342
chr7131839841131839891E082-19186
chr7131839991131840235E082-18842
chr7131840380131840494E082-18583
chr7131842745131842825E082-16252
chr7131842846131842896E082-16181
chr7131842969131843244E082-15833
chr7131843356131843477E082-15600
chr7131845356131846405E082-12672
chr7131846450131846564E082-12513
chr7131846592131846827E082-12250
chr7131846926131847325E082-11752
chr7131847370131847868E082-11209
chr7131847937131847991E082-11086
chr7131861840131862016E0822763
chr7131862056131862145E0822979
chr7131862195131862862E0823118
chr7131868245131868843E0829168
chr7131868880131869103E0829803