rs1027841

Homo sapiens
G>A
ZNF827 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0184 (5524/29978,GnomAD)
A=0167 (4882/29118,TOPMED)
A=0305 (1526/5008,1000G)
A=0162 (625/3854,ALSPAC)
A=0161 (596/3708,TWINSUK)
chr4:145847922 (GRCh38.p7) (4q31.21)
AD
GWASCatalog
1   publication(s)
See rs on genome
171 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.145847922G>A
GRCh37.p13 chr 4NC_000004.11:g.146769074G>A

Gene: ZNF827, zinc finger protein 827(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNF827 transcript variant 1NM_001306215.1:c.N/AIntron Variant
ZNF827 transcript variant 2NM_178835.4:c.N/AIntron Variant
ZNF827 transcript variant X1XM_011531634.2:c.N/AIntron Variant
ZNF827 transcript variant X4XM_011531635.2:c.N/AIntron Variant
ZNF827 transcript variant X14XM_011531645.2:c.N/AIntron Variant
ZNF827 transcript variant X2XM_017007768.1:c.N/AIntron Variant
ZNF827 transcript variant X3XM_017007769.1:c.N/AIntron Variant
ZNF827 transcript variant X5XM_017007770.1:c.N/AIntron Variant
ZNF827 transcript variant X6XM_017007771.1:c.N/AIntron Variant
ZNF827 transcript variant X8XM_017007772.1:c.N/AIntron Variant
ZNF827 transcript variant X9XM_017007773.1:c.N/AIntron Variant
ZNF827 transcript variant X10XM_017007774.1:c.N/AIntron Variant
ZNF827 transcript variant X11XM_017007775.1:c.N/AIntron Variant
ZNF827 transcript variant X12XM_017007776.1:c.N/AIntron Variant
ZNF827 transcript variant X13XM_017007777.1:c.N/AIntron Variant
ZNF827 transcript variant X7XR_001741145.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.904A=0.096
1000GenomesAmericanSub694G=0.580A=0.420
1000GenomesEast AsianSub1008G=0.370A=0.630
1000GenomesEuropeSub1006G=0.830A=0.170
1000GenomesGlobalStudy-wide5008G=0.695A=0.305
1000GenomesSouth AsianSub978G=0.690A=0.310
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.838A=0.162
The Genome Aggregation DatabaseAfricanSub8724G=0.890A=0.110
The Genome Aggregation DatabaseAmericanSub836G=0.540A=0.460
The Genome Aggregation DatabaseEast AsianSub1618G=0.347A=0.653
The Genome Aggregation DatabaseEuropeSub18498G=0.833A=0.166
The Genome Aggregation DatabaseGlobalStudy-wide29978G=0.815A=0.184
The Genome Aggregation DatabaseOtherSub302G=0.850A=0.150
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.832A=0.167
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.839A=0.161
PMID Title Author Journal
23942779A genome-wide association study of behavioral disinhibition.McGue MBehav Genet

P-Value

SNP ID p-value Traits Study
rs10278412E-06alcohol dependence23942779

eQTL of rs1027841 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1027841 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4146741688146741840E067-27234
chr4146760316146760819E067-8255
chr4146761028146761158E067-7916
chr4146768446146768524E067-550
chr4146768562146768648E067-426
chr4146769046146769188E0670
chr4146772200146772755E0673126
chr4146772782146773268E0673708
chr4146773519146773627E0674445
chr4146773697146773840E0674623
chr4146773973146774044E0674899
chr4146800169146800512E06731095
chr4146800703146800799E06731629
chr4146801611146802265E06732537
chr4146802539146802669E06733465
chr4146802726146803588E06733652
chr4146803784146804043E06734710
chr4146804347146804435E06735273
chr4146804569146804697E06735495
chr4146807092146807196E06738018
chr4146807893146809271E06738819
chr4146740322146740697E068-28377
chr4146741688146741840E068-27234
chr4146760316146760819E068-8255
chr4146761028146761158E068-7916
chr4146761387146761641E068-7433
chr4146761652146761706E068-7368
chr4146768446146768524E068-550
chr4146768562146768648E068-426
chr4146769046146769188E0680
chr4146772200146772755E0683126
chr4146772782146773268E0683708
chr4146773519146773627E0684445
chr4146773697146773840E0684623
chr4146790071146790168E06820997
chr4146791283146791822E06822209
chr4146791953146792057E06822879
chr4146800169146800512E06831095
chr4146800703146800799E06831629
chr4146801611146802265E06832537
chr4146802539146802669E06833465
chr4146802726146803588E06833652
chr4146803784146804043E06834710
chr4146804347146804435E06835273
chr4146804569146804697E06835495
chr4146807092146807196E06838018
chr4146807893146809271E06838819
chr4146813242146813411E06844168
chr4146740322146740697E069-28377
chr4146741688146741840E069-27234
chr4146759952146760042E069-9032
chr4146760316146760819E069-8255
chr4146761028146761158E069-7916
chr4146768446146768524E069-550
chr4146768562146768648E069-426
chr4146769046146769188E0690
chr4146772200146772755E0693126
chr4146772782146773268E0693708
chr4146773519146773627E0694445
chr4146773697146773840E0694623
chr4146800169146800512E06931095
chr4146800703146800799E06931629
chr4146800820146801082E06931746
chr4146801611146802265E06932537
chr4146802539146802669E06933465
chr4146802726146803588E06933652
chr4146804347146804435E06935273
chr4146804569146804697E06935495
chr4146807092146807196E06938018
chr4146802539146802669E07033465
chr4146802726146803588E07033652
chr4146803784146804043E07034710
chr4146804347146804435E07035273
chr4146804569146804697E07035495
chr4146740322146740697E071-28377
chr4146741688146741840E071-27234
chr4146760316146760819E071-8255
chr4146761028146761158E071-7916
chr4146761387146761641E071-7433
chr4146768446146768524E071-550
chr4146768562146768648E071-426
chr4146769046146769188E0710
chr4146770268146770325E0711194
chr4146772200146772755E0713126
chr4146772782146773268E0713708
chr4146773519146773627E0714445
chr4146773697146773840E0714623
chr4146791283146791822E07122209
chr4146791953146792057E07122879
chr4146799620146799764E07130546
chr4146800169146800512E07131095
chr4146800703146800799E07131629
chr4146800820146801082E07131746
chr4146801611146802265E07132537
chr4146802539146802669E07133465
chr4146802726146803588E07133652
chr4146803784146804043E07134710
chr4146804347146804435E07135273
chr4146804569146804697E07135495
chr4146807092146807196E07138018
chr4146807893146809271E07138819
chr4146740322146740697E072-28377
chr4146760316146760819E072-8255
chr4146768446146768524E072-550
chr4146768562146768648E072-426
chr4146769046146769188E0720
chr4146772782146773268E0723708
chr4146773519146773627E0724445
chr4146773697146773840E0724623
chr4146800169146800512E07231095
chr4146800703146800799E07231629
chr4146800820146801082E07231746
chr4146801611146802265E07232537
chr4146802539146802669E07233465
chr4146802726146803588E07233652
chr4146804569146804697E07235495
chr4146807092146807196E07238018
chr4146807893146809271E07238819
chr4146740322146740697E073-28377
chr4146740805146741362E073-27712
chr4146741688146741840E073-27234
chr4146772782146773268E0733708
chr4146791953146792057E07322879
chr4146801611146802265E07332537
chr4146802539146802669E07333465
chr4146802726146803588E07333652
chr4146803784146804043E07334710
chr4146804347146804435E07335273
chr4146804569146804697E07335495
chr4146807092146807196E07338018
chr4146740322146740697E074-28377
chr4146759952146760042E074-9032
chr4146760316146760819E074-8255
chr4146761028146761158E074-7916
chr4146768446146768524E074-550
chr4146768562146768648E074-426
chr4146769046146769188E0740
chr4146770268146770325E0741194
chr4146772200146772755E0743126
chr4146772782146773268E0743708
chr4146773519146773627E0744445
chr4146773697146773840E0744623
chr4146773973146774044E0744899
chr4146790272146790494E07421198
chr4146791283146791822E07422209
chr4146800169146800512E07431095
chr4146800703146800799E07431629
chr4146800820146801082E07431746
chr4146801611146802265E07432537
chr4146802539146802669E07433465
chr4146802726146803588E07433652
chr4146803784146804043E07434710
chr4146804347146804435E07435273
chr4146804569146804697E07435495
chr4146807092146807196E07438018
chr4146807893146809271E07438819
chr4146729024146729881E081-39193
chr4146740805146741362E081-27712
chr4146741688146741840E081-27234
chr4146799620146799764E08130546
chr4146800169146800512E08131095
chr4146801611146802265E08132537
chr4146802539146802669E08133465
chr4146802726146803588E08133652
chr4146803784146804043E08134710
chr4146740322146740697E082-28377
chr4146740805146741362E082-27712
chr4146800169146800512E08231095
chr4146803784146804043E08234710
chr4146804347146804435E08235273
chr4146804569146804697E08235495