rs10413195

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

ZNF225 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A==0225 (6558/29118,TOPMED)
A==0208 (5939/28426,GnomAD)
A==0314 (1573/5008,1000G)
A==0115 (443/3854,ALSPAC)
A==0119 (441/3708,TWINSUK)

Position: chr19:44130750 (GRCh38.p7) (19q13.31)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 29 Enhancers around

Promoter: 60 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.44130750A>G
GRCh37.p13 chr 19	NC_000019.9:g.44634903A>G

Gene: ZNF225, zinc finger protein 225(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ZNF225 transcript variant 2	NM_001321685.1:c.	N/A	Intron Variant
ZNF225 transcript variant 1	NM_013362.3:c.	N/A	Intron Variant
ZNF225 transcript variant X3	XM_005259223.3:c.	N/A	Intron Variant
ZNF225 transcript variant X1	XM_011527285.2:c.	N/A	Intron Variant
ZNF225 transcript variant X2	XM_011527286.2:c.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.325	G=0.675
1000Genomes	American	Sub	694	A=0.420	G=0.580
1000Genomes	East Asian	Sub	1008	A=0.496	G=0.504
1000Genomes	Europe	Sub	1006	A=0.129	G=0.871
1000Genomes	Global	Study-wide	5008	A=0.314	G=0.686
1000Genomes	South Asian	Sub	978	A=0.230	G=0.770
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.115	G=0.885
The Genome Aggregation Database	African	Sub	8458	A=0.287	G=0.713
The Genome Aggregation Database	American	Sub	792	A=0.440	G=0.560
The Genome Aggregation Database	East Asian	Sub	1586	A=0.463	G=0.537
The Genome Aggregation Database	Europe	Sub	17296	A=0.138	G=0.861
The Genome Aggregation Database	Global	Study-wide	28426	A=0.208	G=0.791
The Genome Aggregation Database	Other	Sub	294	A=0.120	G=0.880
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.225	G=0.774
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.119	G=0.881

PMID	Title	Author	Journal
23743675	A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.	Kapoor M	Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs10413195	0.000258	alcohol consumption	23743675

eQTL of rs10413195 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10413195 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr19	44670758	44670818	E067	35855
chr19	44670933	44671011	E067	36030
chr19	44671049	44671115	E067	36146
chr19	44618883	44619034	E068	-15869
chr19	44670758	44670818	E068	35855
chr19	44670933	44671011	E068	36030
chr19	44600148	44600194	E069	-34709
chr19	44600148	44600194	E070	-34709
chr19	44618883	44619034	E070	-15869
chr19	44619037	44619091	E070	-15812
chr19	44619125	44619165	E070	-15738
chr19	44670758	44670818	E070	35855
chr19	44670933	44671011	E070	36030
chr19	44671049	44671115	E070	36146
chr19	44671876	44671938	E070	36973
chr19	44618883	44619034	E071	-15869
chr19	44670758	44670818	E071	35855
chr19	44670758	44670818	E072	35855
chr19	44670933	44671011	E072	36030
chr19	44670758	44670818	E074	35855
chr19	44670933	44671011	E074	36030
chr19	44671876	44671938	E074	36973
chr19	44670758	44670818	E081	35855
chr19	44670933	44671011	E081	36030
chr19	44671049	44671115	E081	36146
chr19	44671876	44671938	E081	36973
chr19	44600816	44600930	E082	-33973
chr19	44670933	44671011	E082	36030
chr19	44671049	44671115	E082	36146

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	44598047	44599722	E067	-35181
chr19	44615925	44616789	E067	-18114
chr19	44616806	44618482	E067	-16421
chr19	44644881	44646741	E067	9978
chr19	44668498	44670041	E067	33595
chr19	44597812	44597885	E068	-37018
chr19	44597935	44597989	E068	-36914
chr19	44598047	44599722	E068	-35181
chr19	44615787	44615827	E068	-19076
chr19	44615925	44616789	E068	-18114
chr19	44616806	44618482	E068	-16421
chr19	44644743	44644803	E068	9840
chr19	44644881	44646741	E068	9978
chr19	44668498	44670041	E068	33595
chr19	44598047	44599722	E069	-35181
chr19	44615787	44615827	E069	-19076
chr19	44615925	44616789	E069	-18114
chr19	44616806	44618482	E069	-16421
chr19	44644881	44646741	E069	9978
chr19	44668498	44670041	E069	33595
chr19	44598047	44599722	E070	-35181
chr19	44615925	44616789	E070	-18114
chr19	44616806	44618482	E070	-16421
chr19	44644743	44644803	E070	9840
chr19	44644881	44646741	E070	9978
chr19	44668498	44670041	E070	33595
chr19	44598047	44599722	E071	-35181
chr19	44615787	44615827	E071	-19076
chr19	44615925	44616789	E071	-18114
chr19	44616806	44618482	E071	-16421
chr19	44644743	44644803	E071	9840
chr19	44644881	44646741	E071	9978
chr19	44668498	44670041	E071	33595
chr19	44598047	44599722	E072	-35181
chr19	44615925	44616789	E072	-18114
chr19	44616806	44618482	E072	-16421
chr19	44644743	44644803	E072	9840
chr19	44644881	44646741	E072	9978
chr19	44668498	44670041	E072	33595
chr19	44598047	44599722	E073	-35181
chr19	44615925	44616789	E073	-18114
chr19	44616806	44618482	E073	-16421
chr19	44644881	44646741	E073	9978
chr19	44668498	44670041	E073	33595
chr19	44598047	44599722	E074	-35181
chr19	44615925	44616789	E074	-18114
chr19	44616806	44618482	E074	-16421
chr19	44644881	44646741	E074	9978
chr19	44668498	44670041	E074	33595
chr19	44598047	44599722	E081	-35181
chr19	44615925	44616789	E081	-18114
chr19	44616806	44618482	E081	-16421
chr19	44644881	44646741	E081	9978
chr19	44668498	44670041	E081	33595
chr19	44598047	44599722	E082	-35181
chr19	44615925	44616789	E082	-18114
chr19	44616806	44618482	E082	-16421
chr19	44644743	44644803	E082	9840
chr19	44644881	44646741	E082	9978
chr19	44668498	44670041	E082	33595