rs10423632

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

ZNF415 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0256 (7669/29884,GnomAD)
G=0205 (5995/29118,TOPMED)
G=0235 (1176/5008,1000G)
G=0267 (1029/3854,ALSPAC)
G=0272 (1008/3708,TWINSUK)

Position: chr19:53130297 (GRCh38.p7) (19q13.42)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 63 Enhancers around

Promoter: 42 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 19	NC_000019.10:g.53130297A>G
GRCh37.p13 chr 19	NC_000019.9:g.53633550A>G

Gene: ZNF415, zinc finger protein 415(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ZNF415 transcript variant 1	NM_001136038.2:c.	N/A	Intron Variant
ZNF415 transcript variant 3	NM_001164309.1:c.	N/A	Intron Variant
ZNF415 transcript variant 2	NM_018355.3:c.	N/A	Intron Variant
ZNF415 transcript variant 4	NR_028343.1:n.	N/A	Intron Variant
ZNF415 transcript variant X2	XM_006723267.1:c.	N/A	Intron Variant
ZNF415 transcript variant X17	XM_006723272.2:c.	N/A	Intron Variant
ZNF415 transcript variant X29	XM_006723273.2:c.	N/A	Intron Variant
ZNF415 transcript variant X36	XM_006723274.2:c.	N/A	Intron Variant
ZNF415 transcript variant X24	XM_006723277.2:c.	N/A	Intron Variant
ZNF415 transcript variant X16	XM_006723279.1:c.	N/A	Intron Variant
ZNF415 transcript variant X27	XM_006723280.2:c.	N/A	Intron Variant
ZNF415 transcript variant X37	XM_006723281.2:c.	N/A	Intron Variant
ZNF415 transcript variant X32	XM_006723282.1:c.	N/A	Intron Variant
ZNF415 transcript variant X13	XM_011527100.1:c.	N/A	Intron Variant
ZNF415 transcript variant X12	XM_011527101.2:c.	N/A	Intron Variant
ZNF415 transcript variant X19	XM_011527103.1:c.	N/A	Intron Variant
ZNF415 transcript variant X25	XM_011527104.1:c.	N/A	Intron Variant
ZNF415 transcript variant X3	XM_017026953.1:c.	N/A	Intron Variant
ZNF415 transcript variant X4	XM_017026954.1:c.	N/A	Intron Variant
ZNF415 transcript variant X5	XM_017026955.1:c.	N/A	Intron Variant
ZNF415 transcript variant X8	XM_017026956.1:c.	N/A	Intron Variant
ZNF415 transcript variant X9	XM_017026957.1:c.	N/A	Intron Variant
ZNF415 transcript variant X9	XM_017026959.1:c.	N/A	Intron Variant
ZNF415 transcript variant X10	XM_017026960.1:c.	N/A	Intron Variant
ZNF415 transcript variant X11	XM_017026961.1:c.	N/A	Intron Variant
ZNF415 transcript variant X15	XM_017026962.1:c.	N/A	Intron Variant
ZNF415 transcript variant X16	XM_017026963.1:c.	N/A	Intron Variant
ZNF415 transcript variant X14	XM_017026964.1:c.	N/A	Intron Variant
ZNF415 transcript variant X20	XM_017026965.1:c.	N/A	Intron Variant
ZNF415 transcript variant X21	XM_017026966.1:c.	N/A	Intron Variant
ZNF415 transcript variant X22	XM_017026967.1:c.	N/A	Intron Variant
ZNF415 transcript variant X15	XM_017026968.1:c.	N/A	Intron Variant
ZNF415 transcript variant X18	XM_017026969.1:c.	N/A	Intron Variant
ZNF415 transcript variant X19	XM_017026970.1:c.	N/A	Intron Variant
ZNF415 transcript variant X20	XM_017026971.1:c.	N/A	Intron Variant
ZNF415 transcript variant X33	XM_017026972.1:c.	N/A	Intron Variant
ZNF415 transcript variant X34	XM_017026973.1:c.	N/A	Intron Variant
ZNF415 transcript variant X35	XM_017026974.1:c.	N/A	Intron Variant
ZNF415 transcript variant X11	XM_006723268.1:c.	N/A	Genic Upstream Transcript Variant
ZNF415 transcript variant X1	XM_017026952.1:c.	N/A	Genic Upstream Transcript Variant
ZNF415 transcript variant X8	XM_017026958.1:c.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.918	G=0.082
1000Genomes	American	Sub	694	A=0.630	G=0.370
1000Genomes	East Asian	Sub	1008	A=0.630	G=0.370
1000Genomes	Europe	Sub	1006	A=0.721	G=0.279
1000Genomes	Global	Study-wide	5008	A=0.765	G=0.235
1000Genomes	South Asian	Sub	978	A=0.840	G=0.160
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.733	G=0.267
The Genome Aggregation Database	African	Sub	8716	A=0.870	G=0.130
The Genome Aggregation Database	American	Sub	836	A=0.610	G=0.390
The Genome Aggregation Database	East Asian	Sub	1614	A=0.643	G=0.357
The Genome Aggregation Database	Europe	Sub	18418	A=0.698	G=0.301
The Genome Aggregation Database	Global	Study-wide	29884	A=0.743	G=0.256
The Genome Aggregation Database	Other	Sub	300	A=0.740	G=0.260
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.794	G=0.205
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.728	G=0.272

PMID	Title	Author	Journal
21314694	Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	Kendler KS	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs10423632	0.000608	alcohol dependence	21314694

eQTL of rs10423632 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs10423632 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr19	53601117	53601304	E067	-32246
chr19	53615479	53615523	E067	-18027
chr19	53615665	53615790	E067	-17760
chr19	53634184	53634272	E067	634
chr19	53589918	53590189	E068	-43361
chr19	53590198	53590784	E068	-42766
chr19	53601117	53601304	E068	-32246
chr19	53603039	53603079	E068	-30471
chr19	53603165	53603218	E068	-30332
chr19	53615665	53615790	E068	-17760
chr19	53634184	53634272	E068	634
chr19	53634464	53634623	E068	914
chr19	53660294	53660407	E068	26744
chr19	53660466	53660546	E068	26916
chr19	53615665	53615790	E069	-17760
chr19	53633882	53634138	E069	332
chr19	53634184	53634272	E069	634
chr19	53660294	53660407	E069	26744
chr19	53660466	53660546	E069	26916
chr19	53633882	53634138	E070	332
chr19	53634184	53634272	E070	634
chr19	53634464	53634623	E070	914
chr19	53660294	53660407	E070	26744
chr19	53660466	53660546	E070	26916
chr19	53589918	53590189	E071	-43361
chr19	53590198	53590784	E071	-42766
chr19	53598997	53599068	E071	-34482
chr19	53600642	53600936	E071	-32614
chr19	53601117	53601304	E071	-32246
chr19	53634464	53634623	E071	914
chr19	53589918	53590189	E072	-43361
chr19	53590198	53590784	E072	-42766
chr19	53598997	53599068	E072	-34482
chr19	53601117	53601304	E072	-32246
chr19	53602010	53602060	E072	-31490
chr19	53602414	53602464	E072	-31086
chr19	53615479	53615523	E072	-18027
chr19	53615665	53615790	E072	-17760
chr19	53589597	53589647	E073	-43903
chr19	53589918	53590189	E073	-43361
chr19	53590198	53590784	E073	-42766
chr19	53634464	53634623	E073	914
chr19	53660294	53660407	E073	26744
chr19	53589918	53590189	E074	-43361
chr19	53590198	53590784	E074	-42766
chr19	53603039	53603079	E074	-30471
chr19	53603165	53603218	E074	-30332
chr19	53615665	53615790	E074	-17760
chr19	53625746	53625796	E074	-7754
chr19	53625805	53625859	E074	-7691
chr19	53626001	53626123	E074	-7427
chr19	53626345	53626395	E074	-7155
chr19	53632878	53633011	E074	-539
chr19	53660294	53660407	E074	26744
chr19	53660466	53660546	E074	26916
chr19	53633882	53634138	E081	332
chr19	53634184	53634272	E081	634
chr19	53634464	53634623	E081	914
chr19	53660294	53660407	E081	26744
chr19	53660466	53660546	E081	26916
chr19	53634184	53634272	E082	634
chr19	53660294	53660407	E082	26744
chr19	53660466	53660546	E082	26916

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr19	53604843	53607516	E067	-26034
chr19	53634638	53636543	E067	1088
chr19	53660959	53661904	E067	27409
chr19	53662070	53662999	E067	28520
chr19	53604843	53607516	E068	-26034
chr19	53607566	53607625	E068	-25925
chr19	53634638	53636543	E068	1088
chr19	53660959	53661904	E068	27409
chr19	53662070	53662999	E068	28520
chr19	53604843	53607516	E069	-26034
chr19	53634638	53636543	E069	1088
chr19	53660959	53661904	E069	27409
chr19	53662070	53662999	E069	28520
chr19	53604843	53607516	E070	-26034
chr19	53607566	53607625	E070	-25925
chr19	53634638	53636543	E070	1088
chr19	53660959	53661904	E070	27409
chr19	53662070	53662999	E070	28520
chr19	53604843	53607516	E071	-26034
chr19	53634638	53636543	E071	1088
chr19	53660959	53661904	E071	27409
chr19	53662070	53662999	E071	28520
chr19	53604843	53607516	E072	-26034
chr19	53607566	53607625	E072	-25925
chr19	53634638	53636543	E072	1088
chr19	53660959	53661904	E072	27409
chr19	53662070	53662999	E072	28520
chr19	53604843	53607516	E073	-26034
chr19	53634638	53636543	E073	1088
chr19	53660959	53661904	E073	27409
chr19	53662070	53662999	E073	28520
chr19	53604843	53607516	E074	-26034
chr19	53634638	53636543	E074	1088
chr19	53660959	53661904	E074	27409
chr19	53662070	53662999	E074	28520
chr19	53634638	53636543	E081	1088
chr19	53662070	53662999	E081	28520
chr19	53604843	53607516	E082	-26034
chr19	53607566	53607625	E082	-25925
chr19	53634638	53636543	E082	1088
chr19	53660959	53661904	E082	27409
chr19	53662070	53662999	E082	28520