rs10446322

Homo sapiens
A>G
SLC9A9 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0331 (9909/29928,GnomAD)
A==0310 (9031/29118,TOPMED)
A==0403 (2016/5008,1000G)
A==0421 (1621/3854,ALSPAC)
A==0429 (1589/3708,TWINSUK)
chr3:143349408 (GRCh38.p7) (3q24)
AD
GWASdb2
1   publication(s)
See rs on genome
89 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.143349408A>G
GRCh37.p13 chr 3NC_000003.11:g.143068250A>G
SLC9A9 RefSeqGeneNG_017077.1:g.504124T>C

Gene: SLC9A9, solute carrier family 9 member A9(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SLC9A9 transcriptNM_173653.3:c.N/AIntron Variant
SLC9A9 transcript variant X3XM_011512703.2:c.N/AIntron Variant
SLC9A9 transcript variant X1XM_017006202.1:c.N/AIntron Variant
SLC9A9 transcript variant X2XM_017006203.1:c.N/AIntron Variant
SLC9A9 transcript variant X4XM_011512704.2:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.135G=0.865
1000GenomesAmericanSub694A=0.370G=0.630
1000GenomesEast AsianSub1008A=0.605G=0.395
1000GenomesEuropeSub1006A=0.415G=0.585
1000GenomesGlobalStudy-wide5008A=0.403G=0.597
1000GenomesSouth AsianSub978A=0.570G=0.430
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.421G=0.579
The Genome Aggregation DatabaseAfricanSub8716A=0.176G=0.824
The Genome Aggregation DatabaseAmericanSub838A=0.370G=0.630
The Genome Aggregation DatabaseEast AsianSub1610A=0.614G=0.386
The Genome Aggregation DatabaseEuropeSub18462A=0.376G=0.623
The Genome Aggregation DatabaseGlobalStudy-wide29928A=0.331G=0.668
The Genome Aggregation DatabaseOtherSub302A=0.430G=0.570
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.310G=0.689
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.429G=0.571
PMID Title Author Journal
23089632A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.Wang JCMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs104463220.00000173alcohol dependence23089632
rs104463220.0000577alcohol dependence23089632

eQTL of rs10446322 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10446322 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3143048485143048606E067-19644
chr3143049956143050074E067-18176
chr3143050233143050516E067-17734
chr3143061820143062271E067-5979
chr3143062591143062850E067-5400
chr3143032753143033804E068-34446
chr3143034598143034658E068-33592
chr3143048485143048606E068-19644
chr3143048684143049027E068-19223
chr3143049079143049314E068-18936
chr3143049352143049544E068-18706
chr3143049735143049860E068-18390
chr3143049956143050074E068-18176
chr3143050233143050516E068-17734
chr3143062591143062850E068-5400
chr3143077113143077227E0688863
chr3143077303143077353E0689053
chr3143077831143077881E0689581
chr3143078088143078343E0689838
chr3143048485143048606E069-19644
chr3143048684143049027E069-19223
chr3143049079143049314E069-18936
chr3143049352143049544E069-18706
chr3143049735143049860E069-18390
chr3143049956143050074E069-18176
chr3143050233143050516E069-17734
chr3143077113143077227E0698863
chr3143077303143077353E0699053
chr3143077831143077881E0699581
chr3143078088143078343E0699838
chr3143032753143033804E071-34446
chr3143034598143034658E071-33592
chr3143049352143049544E071-18706
chr3143049735143049860E071-18390
chr3143049956143050074E071-18176
chr3143050233143050516E071-17734
chr3143050544143051256E071-16994
chr3143062591143062850E071-5400
chr3143077113143077227E0718863
chr3143077303143077353E0719053
chr3143021314143021457E072-46793
chr3143021458143022149E072-46101
chr3143048485143048606E072-19644
chr3143049352143049544E072-18706
chr3143049735143049860E072-18390
chr3143049956143050074E072-18176
chr3143050233143050516E072-17734
chr3143077113143077227E0728863
chr3143077303143077353E0729053
chr3143077831143077881E0729581
chr3143078088143078343E0729838
chr3143048485143048606E073-19644
chr3143048684143049027E073-19223
chr3143049735143049860E073-18390
chr3143049956143050074E073-18176
chr3143049079143049314E074-18936
chr3143049352143049544E074-18706
chr3143049735143049860E074-18390
chr3143049956143050074E074-18176
chr3143050233143050516E074-17734
chr3143062591143062850E074-5400
chr3143062891143063112E074-5138
chr3143063169143063255E074-4995
chr3143063497143063728E074-4522
chr3143077113143077227E0748863
chr3143077303143077353E0749053
chr3143077831143077881E0749581
chr3143078088143078343E0749838
chr3143032753143033804E081-34446
chr3143047831143047907E081-20343
chr3143048485143048606E081-19644
chr3143048684143049027E081-19223
chr3143049079143049314E081-18936
chr3143049352143049544E081-18706
chr3143049735143049860E081-18390
chr3143049956143050074E081-18176
chr3143050233143050516E081-17734
chr3143050544143051256E081-16994
chr3143052386143052488E081-15762
chr3143047365143047584E082-20666
chr3143047831143047907E082-20343
chr3143048485143048606E082-19644
chr3143048684143049027E082-19223
chr3143049079143049314E082-18936
chr3143049352143049544E082-18706
chr3143049735143049860E082-18390
chr3143049956143050074E082-18176
chr3143051973143052092E082-16158
chr3143052386143052488E082-15762