rs10454701

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0122 (3673/29960,GnomAD)
G=0099 (2886/29118,TOPMED)
G=0052 (259/5008,1000G)
G=0177 (684/3854,ALSPAC)
G=0173 (643/3708,TWINSUK)
chr16:19143368 (GRCh38.p7) (16p12.3)
CD
GWASdb2
1   publication(s)
See rs on genome
91 Enhancers around
34 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.19143368A>G
GRCh37.p13 chr 16NC_000016.9:g.19154690A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.994G=0.006
1000GenomesAmericanSub694A=0.900G=0.100
1000GenomesEast AsianSub1008A=0.999G=0.001
1000GenomesEuropeSub1006A=0.846G=0.154
1000GenomesGlobalStudy-wide5008A=0.948G=0.052
1000GenomesSouth AsianSub978A=0.980G=0.020
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.823G=0.177
The Genome Aggregation DatabaseAfricanSub8722A=0.970G=0.030
The Genome Aggregation DatabaseAmericanSub838A=0.920G=0.080
The Genome Aggregation DatabaseEast AsianSub1622A=1.000G=0.000
The Genome Aggregation DatabaseEuropeSub18476A=0.821G=0.178
The Genome Aggregation DatabaseGlobalStudy-wide29960A=0.877G=0.122
The Genome Aggregation DatabaseOtherSub302A=0.860G=0.140
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.900G=0.099
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.827G=0.173
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs104547012.69E-05cocaine dependence23958962

eQTL of rs10454701 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10454701 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr161912733719127377E067-27313
chr161912748919127608E067-27082
chr161914184219143259E067-11431
chr161911688819116997E068-37693
chr161912710519127160E068-27530
chr161912733719127377E068-27313
chr161912748919127608E068-27082
chr161912765719127795E068-26895
chr161912785119127901E068-26789
chr161912807319128900E068-25790
chr161912892719129314E068-25376
chr161913100819131281E068-23409
chr161914021419140493E068-14197
chr161914064519140695E068-13995
chr161914075919141236E068-13454
chr161914149219141587E068-13103
chr161914172519141775E068-12915
chr161914184219143259E068-11431
chr161914326719143470E068-11220
chr161914802519148167E068-6523
chr161914820419148916E068-5774
chr161915450619155012E0680
chr161919712019197298E06842430
chr161912733719127377E069-27313
chr161912807319128900E069-25790
chr161913100819131281E069-23409
chr161914184219143259E069-11431
chr161914326719143470E069-11220
chr161914726419147866E069-6824
chr161914802519148167E069-6523
chr161918224419182294E06927554
chr161919601419196603E06941324
chr161919682019196870E06942130
chr161919696419197091E06942274
chr161919712019197298E06942430
chr161918155819181622E07026868
chr161912733719127377E071-27313
chr161912748919127608E071-27082
chr161912765719127795E071-26895
chr161912785119127901E071-26789
chr161912892719129314E071-25376
chr161913100819131281E071-23409
chr161914021419140493E071-14197
chr161914064519140695E071-13995
chr161914149219141587E071-13103
chr161914172519141775E071-12915
chr161914184219143259E071-11431
chr161914326719143470E071-11220
chr161914370819143959E071-10731
chr161914726419147866E071-6824
chr161914802519148167E071-6523
chr161919601419196603E07141324
chr161914149219141587E072-13103
chr161914172519141775E072-12915
chr161914184219143259E072-11431
chr161914326719143470E072-11220
chr161912733719127377E073-27313
chr161912807319128900E073-25790
chr161914184219143259E073-11431
chr161914326719143470E073-11220
chr161914726419147866E073-6824
chr161914802519148167E073-6523
chr161914820419148916E073-5774
chr161919682019196870E07342130
chr161919696419197091E07342274
chr161919712019197298E07342430
chr161919779919198020E07343109
chr161912710519127160E074-27530
chr161912733719127377E074-27313
chr161912748919127608E074-27082
chr161912765719127795E074-26895
chr161912785119127901E074-26789
chr161913100819131281E074-23409
chr161914010719140164E074-14526
chr161914021419140493E074-14197
chr161914064519140695E074-13995
chr161914075919141236E074-13454
chr161914149219141587E074-13103
chr161914172519141775E074-12915
chr161914184219143259E074-11431
chr161914326719143470E074-11220
chr161914370819143959E074-10731
chr161914820419148916E081-5774
chr161914980819150806E081-3884
chr161915084019150997E081-3693
chr161915835619158450E0813666
chr161915857119158730E0813881
chr161915896819159040E0814278
chr161919106619191841E08136376
chr161919188819191938E08137198
chr161915857119158730E0823881










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr161912475219126654E067-28036
chr161917890719180625E06724217
chr161918069419181065E06726004
chr161912475219126654E068-28036
chr161917890719180625E06824217
chr161918069419181065E06826004
chr161912475219126654E069-28036
chr161917890719180625E06924217
chr161918069419181065E06926004
chr161918432819184570E06929638
chr161912475219126654E070-28036
chr161917890719180625E07024217
chr161918069419181065E07026004
chr161917890719180625E07124217
chr161918069419181065E07126004
chr161918432819184570E07129638
chr161918459519184635E07129905
chr161912475219126654E072-28036
chr161917890719180625E07224217
chr161918069419181065E07226004
chr161918432819184570E07229638
chr161918459519184635E07229905
chr161918478019184899E07230090
chr161918495719185007E07230267
chr161918508319185328E07230393
chr161918536119185658E07230671
chr161917890719180625E07324217
chr161918069419181065E07326004
chr161912475219126654E074-28036
chr161917890719180625E07424217
chr161918069419181065E07426004
chr161912475219126654E082-28036
chr161917890719180625E08224217
chr161918069419181065E08226004