rs10456773

Homo sapiens
T>C
DTNBP1 : Intron Variant
LOC105374947 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0144 (4320/29948,GnomAD)
C=0132 (3862/29118,TOPMED)
C=0174 (871/5008,1000G)
C=0148 (571/3854,ALSPAC)
C=0150 (556/3708,TWINSUK)
chr6:15537094 (GRCh38.p7) (6p22.3)
AD
GWASdb2
2   publication(s)
See rs on genome
231 Enhancers around
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.15537094T>C
GRCh37.p13 chr 6NC_000006.11:g.15537325T>C
DTNBP1 RefSeqGene LRG_588

Gene: DTNBP1, dystrobrevin binding protein 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
DTNBP1 transcript variant 3NM_001271667.1:c.N/AIntron Variant
DTNBP1 transcript variant 5NM_001271668.1:c.N/AIntron Variant
DTNBP1 transcript variant 6NM_001271669.1:c.N/AIntron Variant
DTNBP1 transcript variant 1NM_032122.4:c.N/AIntron Variant
DTNBP1 transcript variant 2NM_183040.2:c.N/AIntron Variant
DTNBP1 transcript variant 4NR_036448.1:n.N/AIntron Variant
DTNBP1 transcript variant X1XM_005249447.4:c.N/AIntron Variant
DTNBP1 transcript variant X2XM_011514936.2:c.N/AIntron Variant
DTNBP1 transcript variant X6XM_011514937.2:c.N/AIntron Variant
DTNBP1 transcript variant X4XM_017011348.1:c.N/AGenic Upstream Transcript Variant
DTNBP1 transcript variant X5XM_017011349.1:c.N/AGenic Upstream Transcript Variant

Gene: LOC105374947, uncharacterized LOC105374947(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105374947 transcriptXR_001743795.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.923C=0.077
1000GenomesAmericanSub694T=0.810C=0.190
1000GenomesEast AsianSub1008T=0.684C=0.316
1000GenomesEuropeSub1006T=0.830C=0.170
1000GenomesGlobalStudy-wide5008T=0.826C=0.174
1000GenomesSouth AsianSub978T=0.850C=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.852C=0.148
The Genome Aggregation DatabaseAfricanSub8724T=0.916C=0.084
The Genome Aggregation DatabaseAmericanSub836T=0.840C=0.160
The Genome Aggregation DatabaseEast AsianSub1618T=0.692C=0.308
The Genome Aggregation DatabaseEuropeSub18468T=0.844C=0.155
The Genome Aggregation DatabaseGlobalStudy-wide29948T=0.855C=0.144
The Genome Aggregation DatabaseOtherSub302T=0.710C=0.290
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.867C=0.132
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.850C=0.150
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res
17033966Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.Mutsuddi MAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs104567730.000954alcohol dependence21314694

eQTL of rs10456773 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10456773 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr61549107315491177E067-46148
chr61549128515491342E067-45983
chr61549136615491456E067-45869
chr61549149115491979E067-45346
chr61549223815492288E067-45037
chr61549231015492383E067-44942
chr61549557515496148E067-41177
chr61550198815502050E067-35275
chr61550205715502653E067-34672
chr61550266615503566E067-33759
chr61550371515503779E067-33546
chr61550388615504195E067-33130
chr61550585215506202E067-31123
chr61551120215511278E067-26047
chr61552183415522184E067-15141
chr61552244715522561E067-14764
chr61553904515539303E0671720
chr61554995215550098E06712627
chr61555016115550260E06712836
chr61557779315577896E06740468
chr61557793415578051E06740609
chr61557812515578249E06740800
chr61549107315491177E068-46148
chr61549128515491342E068-45983
chr61549136615491456E068-45869
chr61549149115491979E068-45346
chr61549223815492288E068-45037
chr61549231015492383E068-44942
chr61549557515496148E068-41177
chr61550080615500871E068-36454
chr61550167615501794E068-35531
chr61550198815502050E068-35275
chr61550205715502653E068-34672
chr61550266615503566E068-33759
chr61550371515503779E068-33546
chr61550388615504195E068-33130
chr61550585215506202E068-31123
chr61550658515506625E068-30700
chr61551120215511278E068-26047
chr61551156515511701E068-25624
chr61551208315512278E068-25047
chr61551250715512652E068-24673
chr61552183415522184E068-15141
chr61552244715522561E068-14764
chr61552273515522993E068-14332
chr61553904515539303E0681720
chr61554012915540237E0682804
chr61554131615541580E0683991
chr61554694915547077E0689624
chr61554720015547274E0689875
chr61554737615548025E06810051
chr61555108615551188E06813761
chr61555156315551928E06814238
chr61555200915552378E06814684
chr61557779315577896E06840468
chr61557793415578051E06840609
chr61557812515578249E06840800
chr61557842615578514E06841101
chr61557854815578649E06841223
chr61557867815578734E06841353
chr61558687615587077E06849551
chr61549107315491177E069-46148
chr61549128515491342E069-45983
chr61549136615491456E069-45869
chr61549149115491979E069-45346
chr61550167615501794E069-35531
chr61550198815502050E069-35275
chr61550205715502653E069-34672
chr61550266615503566E069-33759
chr61550371515503779E069-33546
chr61550388615504195E069-33130
chr61550585215506202E069-31123
chr61550658515506625E069-30700
chr61550918015509415E069-27910
chr61550962015509707E069-27618
chr61551156515511701E069-25624
chr61551208315512278E069-25047
chr61551250715512652E069-24673
chr61552183415522184E069-15141
chr61552244715522561E069-14764
chr61553904515539303E0691720
chr61555156315551928E06914238
chr61555200915552378E06914684
chr61549149115491979E070-45346
chr61549644315496600E070-40725
chr61550198815502050E070-35275
chr61550205715502653E070-34672
chr61550266615503566E070-33759
chr61550371515503779E070-33546
chr61550388615504195E070-33130
chr61550585215506202E070-31123
chr61550658515506625E070-30700
chr61549007715490127E071-47198
chr61549018015490235E071-47090
chr61549038515490501E071-46824
chr61549056515490729E071-46596
chr61549075215490811E071-46514
chr61549089715490947E071-46378
chr61549107315491177E071-46148
chr61549128515491342E071-45983
chr61549136615491456E071-45869
chr61549149115491979E071-45346
chr61549223815492288E071-45037
chr61549231015492383E071-44942
chr61549367915494015E071-43310
chr61550205715502653E071-34672
chr61550266615503566E071-33759
chr61550371515503779E071-33546
chr61550388615504195E071-33130
chr61550585215506202E071-31123
chr61550658515506625E071-30700
chr61550806815508170E071-29155
chr61550824415508398E071-28927
chr61550860315508722E071-28603
chr61550875315509164E071-28161
chr61550918015509415E071-27910
chr61550962015509707E071-27618
chr61551120215511278E071-26047
chr61551156515511701E071-25624
chr61552244715522561E071-14764
chr61552273515522993E071-14332
chr61553580615536098E071-1227
chr61553614915536242E071-1083
chr61553627415536386E071-939
chr61553904515539303E0711720
chr61554012915540237E0712804
chr61555108615551188E07113761
chr61555156315551928E07114238
chr61555200915552378E07114684
chr61549056515490729E072-46596
chr61549075215490811E072-46514
chr61549089715490947E072-46378
chr61549107315491177E072-46148
chr61549128515491342E072-45983
chr61549136615491456E072-45869
chr61549149115491979E072-45346
chr61549223815492288E072-45037
chr61549231015492383E072-44942
chr61550080615500871E072-36454
chr61550167615501794E072-35531
chr61550198815502050E072-35275
chr61550205715502653E072-34672
chr61550266615503566E072-33759
chr61550371515503779E072-33546
chr61550388615504195E072-33130
chr61550585215506202E072-31123
chr61550918015509415E072-27910
chr61550962015509707E072-27618
chr61550995215510079E072-27246
chr61551120215511278E072-26047
chr61551156515511701E072-25624
chr61551208315512278E072-25047
chr61551250715512652E072-24673
chr61552183415522184E072-15141
chr61552244715522561E072-14764
chr61552273515522993E072-14332
chr61553904515539303E0721720
chr61555108615551188E07213761
chr61555156315551928E07214238
chr61555200915552378E07214684
chr61548954215489755E073-47570
chr61549149115491979E073-45346
chr61549223815492288E073-45037
chr61549231015492383E073-44942
chr61549248615492630E073-44695
chr61549279615492851E073-44474
chr61549557515496148E073-41177
chr61550167615501794E073-35531
chr61550198815502050E073-35275
chr61550205715502653E073-34672
chr61550266615503566E073-33759
chr61550371515503779E073-33546
chr61550388615504195E073-33130
chr61550585215506202E073-31123
chr61550658515506625E073-30700
chr61550860315508722E073-28603
chr61550875315509164E073-28161
chr61550918015509415E073-27910
chr61550962015509707E073-27618
chr61550995215510079E073-27246
chr61551120215511278E073-26047
chr61551156515511701E073-25624
chr61551208315512278E073-25047
chr61551421515514316E073-23009
chr61551435815514408E073-22917
chr61551477415514938E073-22387
chr61552183415522184E073-15141
chr61552244715522561E073-14764
chr61553904515539303E0731720
chr61554995215550098E07312627
chr61555016115550260E07312836
chr61555108615551188E07313761
chr61555156315551928E07314238
chr61555200915552378E07314684
chr61549038515490501E074-46824
chr61549056515490729E074-46596
chr61549075215490811E074-46514
chr61549089715490947E074-46378
chr61549107315491177E074-46148
chr61549128515491342E074-45983
chr61549136615491456E074-45869
chr61549149115491979E074-45346
chr61549223815492288E074-45037
chr61549231015492383E074-44942
chr61550205715502653E074-34672
chr61550266615503566E074-33759
chr61550371515503779E074-33546
chr61550388615504195E074-33130
chr61550585215506202E074-31123
chr61550658515506625E074-30700
chr61550875315509164E074-28161
chr61550918015509415E074-27910
chr61550962015509707E074-27618
chr61550995215510079E074-27246
chr61551120215511278E074-26047
chr61551156515511701E074-25624
chr61551208315512278E074-25047
chr61551250715512652E074-24673
chr61552183415522184E074-15141
chr61552244715522561E074-14764
chr61552273515522993E074-14332
chr61552785015527930E074-9395
chr61553904515539303E0741720
chr61549136615491456E081-45869
chr61549149115491979E081-45346
chr61550198815502050E081-35275
chr61550205715502653E081-34672
chr61550266615503566E081-33759
chr61550371515503779E081-33546
chr61550388615504195E081-33130
chr61550585215506202E081-31123









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr61558365715583707E06846332