rs10457526

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0210 (6305/29904,GnomAD)
T=0203 (5915/29118,TOPMED)
T=0250 (1250/5008,1000G)
T=0210 (810/3854,ALSPAC)
T=0206 (765/3708,TWINSUK)
chr6:129575356 (GRCh38.p7) (6q22.33)
AD
GWASCatalog
2   publication(s)
See rs on genome
45 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.129575356G>T
GRCh37.p13 chr 6NC_000006.11:g.129896501G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.831T=0.169
1000GenomesAmericanSub694G=0.630T=0.370
1000GenomesEast AsianSub1008G=0.760T=0.240
1000GenomesEuropeSub1006G=0.800T=0.200
1000GenomesGlobalStudy-wide5008G=0.750T=0.250
1000GenomesSouth AsianSub978G=0.670T=0.330
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.790T=0.210
The Genome Aggregation DatabaseAfricanSub8702G=0.799T=0.201
The Genome Aggregation DatabaseAmericanSub836G=0.650T=0.350
The Genome Aggregation DatabaseEast AsianSub1606G=0.700T=0.300
The Genome Aggregation DatabaseEuropeSub18458G=0.798T=0.201
The Genome Aggregation DatabaseGlobalStudy-wide29904G=0.789T=0.210
The Genome Aggregation DatabaseOtherSub302G=0.790T=0.210
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.796T=0.203
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.794T=0.206
PMID Title Author Journal
19065146Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.Potkin SGMol Psychiatry
29460428Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.Gelernter JAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs104575265E-06response to alcohol29460428

eQTL of rs10457526 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10457526 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6129919805129919970E06823304
chr6129919994129920056E06823493
chr6129928462129928772E06831961
chr6129927094129927159E07030593
chr6129927229129927369E07030728
chr6129927571129927721E07031070
chr6129927883129928034E07031382
chr6129928462129928772E07031961
chr6129930320129930642E07033819
chr6129930645129930718E07034144
chr6129930860129931131E07034359
chr6129931429129931505E07034928
chr6129931633129931738E07035132
chr6129933488129933552E07036987
chr6129857073129857127E071-39374
chr6129928462129928772E07131961
chr6129928462129928772E07231961
chr6129856161129856404E081-40097
chr6129857073129857127E081-39374
chr6129857196129858164E081-38337
chr6129859244129859294E081-37207
chr6129860426129860476E081-36025
chr6129927094129927159E08130593
chr6129927229129927369E08130728
chr6129927571129927721E08131070
chr6129927883129928034E08131382
chr6129928462129928772E08131961
chr6129929906129930007E08133405
chr6129930320129930642E08133819
chr6129930645129930718E08134144
chr6129930860129931131E08134359
chr6129931429129931505E08134928
chr6129931633129931738E08135132
chr6129857196129858164E082-38337
chr6129859244129859294E082-37207
chr6129919994129920056E08223493
chr6129920108129920203E08223607
chr6129920728129920920E08224227
chr6129928462129928772E08231961
chr6129929906129930007E08233405
chr6129930320129930642E08233819
chr6129930645129930718E08234144
chr6129930860129931131E08234359
chr6129931429129931505E08234928
chr6129933488129933552E08236987






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr6129896359129897119E0670
chr6129896359129897119E0680
chr6129896359129897119E0690
chr6129896359129897119E0710
chr6129896359129897119E0720
chr6129896359129897119E0730