rs10490996

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0086 (2600/29976,GnomAD)
A=0090 (2635/29118,TOPMED)
A=0084 (419/5008,1000G)
A=0082 (317/3854,ALSPAC)
A=0080 (297/3708,TWINSUK)
chr10:78371685 (GRCh38.p7) (10q22.3)
AD
GWASdb2
2   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.78371685G>A
GRCh37.p13 chr 10NC_000010.10:g.80131442G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.894A=0.106
1000GenomesAmericanSub694G=0.880A=0.120
1000GenomesEast AsianSub1008G=0.968A=0.032
1000GenomesEuropeSub1006G=0.921A=0.079
1000GenomesGlobalStudy-wide5008G=0.916A=0.084
1000GenomesSouth AsianSub978G=0.910A=0.090
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.918A=0.082
The Genome Aggregation DatabaseAfricanSub8724G=0.900A=0.100
The Genome Aggregation DatabaseAmericanSub838G=0.870A=0.130
The Genome Aggregation DatabaseEast AsianSub1620G=0.973A=0.027
The Genome Aggregation DatabaseEuropeSub18492G=0.916A=0.083
The Genome Aggregation DatabaseGlobalStudy-wide29976G=0.913A=0.086
The Genome Aggregation DatabaseOtherSub302G=0.870A=0.130
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.909A=0.090
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.920A=0.080
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
21302341Replicated genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs.Drgon TAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs104909960.00042alcohol dependence20201924

eQTL of rs10490996 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10490996 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr108010822780108277E067-23165
chr108010833980108560E067-22882
chr108012595380126104E067-5338
chr108013540580135567E0673963
chr108013560880136066E0674166
chr108013610080136538E0674658
chr108016581180165917E06734369
chr108018056680180626E06749124
chr108009234080092429E068-39013
chr108009250580092585E068-38857
chr108009456580094648E068-36794
chr108009482180094871E068-36571
chr108009502880095104E068-36338
chr108009913680099410E068-32032
chr108011672480117857E068-13585
chr108012542980125935E068-5507
chr108012595380126104E068-5338
chr108013079380131211E068-231
chr108013540580135567E0683963
chr108013560880136066E0684166
chr108013610080136538E0684658
chr108016301280163146E06831570
chr108018056680180626E06849124
chr108009205880092127E069-39315
chr108009894880099062E069-32380
chr108009913680099410E069-32032
chr108010822780108277E069-23165
chr108010833980108560E069-22882
chr108010862480108736E069-22706
chr108010875080108834E069-22608
chr108011635180116642E069-14800
chr108011672480117857E069-13585
chr108011795880118068E069-13374
chr108012178980121830E069-9612
chr108012184880121949E069-9493
chr108012197080122043E069-9399
chr108012213380122703E069-8739
chr108012526380125364E069-6078
chr108012542980125935E069-5507
chr108012595380126104E069-5338
chr108012622280126436E069-5006
chr108012653980126776E069-4666
chr108012678480127208E069-4234
chr108012807580128130E069-3312
chr108013540580135567E0693963
chr108013560880136066E0694166
chr108013610080136538E0694658
chr108016581180165917E06934369
chr108016596080166031E06934518
chr108016607480166139E06934632
chr108016614180166191E06934699
chr108017576880176724E06944326
chr108018056680180626E06949124
chr108009121980091615E070-39827
chr108009162280092024E070-39418
chr108009780180097998E070-33444
chr108009894880099062E070-32380
chr108011622980116345E070-15097
chr108011635180116642E070-14800
chr108011672480117857E070-13585
chr108011795880118068E070-13374
chr108011814080118292E070-13150
chr108011873680118786E070-12656
chr108011879080118948E070-12494
chr108011914680119257E070-12185
chr108011934480120166E070-11276
chr108012017880120228E070-11214
chr108012052980120840E070-10602
chr108012084780121188E070-10254
chr108012129680121346E070-10096
chr108012137780121417E070-10025
chr108012157080121672E070-9770
chr108012178980121830E070-9612
chr108012184880121949E070-9493
chr108012197080122043E070-9399
chr108012526380125364E070-6078
chr108012542980125935E070-5507
chr108012595380126104E070-5338
chr108012622280126436E070-5006
chr108012653980126776E070-4666
chr108012678480127208E070-4234
chr108012722980127304E070-4138
chr108012740880127468E070-3974
chr108012758080127634E070-3808
chr108012766780127766E070-3676
chr108012779780127909E070-3533
chr108012807580128130E070-3312
chr108012819480128244E070-3198
chr108012830180128341E070-3101
chr108013079380131211E070-231
chr108013151680131570E07074
chr108013176680131925E070324
chr108013279280132895E0701350
chr108013298180133062E0701539
chr108013540580135567E0703963
chr108013610080136538E0704658
chr108013662580136822E0705183
chr108013693480137035E0705492
chr108013708580137171E0705643
chr108013719380137506E0705751
chr108013758480137655E0706142
chr108013776080137908E0706318
chr108014634780146492E07014905
chr108016014980160292E07028707
chr108016123680162702E07029794
chr108016596080166031E07034518
chr108016640780169252E07034965
chr108016929580169438E07037853
chr108016948880169542E07038046
chr108016962680169701E07038184
chr108017945980179510E07048017
chr108018049180180557E07049049
chr108018056680180626E07049124
chr108009121980091615E071-39827
chr108009162280092024E071-39418
chr108009205880092127E071-39315
chr108009894880099062E071-32380
chr108009913680099410E071-32032
chr108010862480108736E071-22706
chr108010875080108834E071-22608
chr108011879080118948E071-12494
chr108011914680119257E071-12185
chr108011934480120166E071-11276
chr108012542980125935E071-5507
chr108012595380126104E071-5338
chr108012622280126436E071-5006
chr108012653980126776E071-4666
chr108012678480127208E071-4234
chr108013079380131211E071-231
chr108013560880136066E0714166
chr108013610080136538E0714658
chr108013662580136822E0715183
chr108013693480137035E0715492
chr108013708580137171E0715643
chr108013719380137506E0715751
chr108013758480137655E0716142
chr108014634780146492E07114905
chr108016534580165426E07133903
chr108016544480165748E07134002
chr108016581180165917E07134369
chr108016596080166031E07134518
chr108016640780169252E07134965
chr108017576880176724E07144326
chr108018056680180626E07149124
chr108010833980108560E072-22882
chr108010862480108736E072-22706
chr108010875080108834E072-22608
chr108012542980125935E072-5507
chr108012595380126104E072-5338
chr108012758080127634E072-3808
chr108012766780127766E072-3676
chr108012779780127909E072-3533
chr108012807580128130E072-3312
chr108012819480128244E072-3198
chr108013540580135567E0723963
chr108013560880136066E0724166
chr108013610080136538E0724658
chr108014191580142021E07210473
chr108009162280092024E073-39418
chr108009205880092127E073-39315
chr108009234080092429E073-39013
chr108009250580092585E073-38857
chr108009357480093624E073-37818
chr108009502880095104E073-36338
chr108009517180096504E073-34938
chr108011672480117857E073-13585
chr108011795880118068E073-13374
chr108011814080118292E073-13150
chr108013540580135567E0733963
chr108013560880136066E0734166
chr108013610080136538E0734658
chr108013662580136822E0735183
chr108013693480137035E0735492
chr108013708580137171E0735643
chr108013719380137506E0735751
chr108013758480137655E0736142
chr108016484380164893E07333401
chr108016512280165239E07333680
chr108016534580165426E07333903
chr108016544480165748E07334002
chr108016581180165917E07334369
chr108016596080166031E07334518
chr108016607480166139E07334632
chr108016614180166191E07334699
chr108016640780169252E07334965
chr108018056680180626E07349124
chr108009106280091149E074-40293
chr108009517180096504E074-34938
chr108009894880099062E074-32380
chr108009913680099410E074-32032
chr108010822780108277E074-23165
chr108010833980108560E074-22882
chr108012542980125935E074-5507
chr108012595380126104E074-5338
chr108012766780127766E074-3676
chr108013560880136066E0744166
chr108013610080136538E0744658
chr108016627380166361E07434831
chr108016640780169252E07434965
chr108018056680180626E07449124
chr108011010280110309E081-21133
chr108011635180116642E081-14800
chr108011672480117857E081-13585
chr108011795880118068E081-13374
chr108011814080118292E081-13150
chr108011873680118786E081-12656
chr108011879080118948E081-12494
chr108011914680119257E081-12185
chr108011934480120166E081-11276
chr108012017880120228E081-11214
chr108012052980120840E081-10602
chr108012084780121188E081-10254
chr108012360080123843E081-7599
chr108012406180124225E081-7217
chr108012429880124348E081-7094
chr108012441080124460E081-6982
chr108012449880124607E081-6835
chr108012469680124817E081-6625
chr108012484280124931E081-6511
chr108012502280125091E081-6351
chr108012512680125186E081-6256
chr108012526380125364E081-6078
chr108012542980125935E081-5507
chr108012595380126104E081-5338
chr108012622280126436E081-5006
chr108012653980126776E081-4666
chr108012678480127208E081-4234
chr108012722980127304E081-4138
chr108013079380131211E081-231
chr108013151680131570E08174
chr108013176680131925E081324
chr108013279280132895E0811350
chr108013298180133062E0811539
chr108013445980134509E0813017
chr108013452080134574E0813078
chr108013474980134835E0813307
chr108013488980134939E0813447
chr108013524280135384E0813800
chr108013540580135567E0813963
chr108013560880136066E0814166
chr108013610080136538E0814658
chr108013662580136822E0815183
chr108013693480137035E0815492
chr108013708580137171E0815643
chr108013719380137506E0815751
chr108013758480137655E0816142
chr108014025480140318E0818812
chr108014039580140618E0818953
chr108014080680140885E0819364
chr108014094980141069E0819507
chr108014114880141229E0819706
chr108014634780146492E08114905
chr108014670280146752E08115260
chr108015963980160049E08128197
chr108016014980160292E08128707
chr108016045980160528E08129017
chr108016092780160992E08129485
chr108016123680162702E08129794
chr108016301280163146E08131570
chr108016330780163357E08131865
chr108016345180163569E08132009
chr108016371180163830E08132269
chr108016387780163927E08132435
chr108016544480165748E08134002
chr108016581180165917E08134369
chr108016596080166031E08134518
chr108016607480166139E08134632
chr108016614180166191E08134699
chr108016627380166361E08134831
chr108016640780169252E08134965
chr108016929580169438E08137853
chr108017104980171099E08139607
chr108017113180171185E08139689
chr108017165780171929E08140215
chr108017219680172335E08140754
chr108017240380172618E08140961
chr108017262780173445E08141185
chr108017368080173734E08142238
chr108017376280173812E08142320
chr108017774080177812E08146298
chr108017787080177924E08146428
chr108017798980178043E08146547
chr108017818780178261E08146745
chr108017883980178969E08147397
chr108017930980179359E08147867
chr108017945980179510E08148017
chr108017958180179692E08148139
chr108017975180179824E08148309
chr108017994980179999E08148507
chr108018031780180374E08148875
chr108018049180180557E08149049
chr108018056680180626E08149124
chr108011635180116642E082-14800
chr108011672480117857E082-13585
chr108011795880118068E082-13374
chr108011814080118292E082-13150
chr108011873680118786E082-12656
chr108011879080118948E082-12494
chr108011914680119257E082-12185
chr108011934480120166E082-11276
chr108012017880120228E082-11214
chr108012052980120840E082-10602
chr108012129680121346E082-10096
chr108012336280123433E082-8009
chr108012360080123843E082-7599
chr108012406180124225E082-7217
chr108012429880124348E082-7094
chr108012441080124460E082-6982
chr108012449880124607E082-6835
chr108012469680124817E082-6625
chr108012484280124931E082-6511
chr108012502280125091E082-6351
chr108012512680125186E082-6256
chr108012526380125364E082-6078
chr108012542980125935E082-5507
chr108012595380126104E082-5338
chr108012622280126436E082-5006
chr108012653980126776E082-4666
chr108012678480127208E082-4234
chr108012722980127304E082-4138
chr108012740880127468E082-3974
chr108012758080127634E082-3808
chr108012766780127766E082-3676
chr108012779780127909E082-3533
chr108013279280132895E0821350
chr108013298180133062E0821539
chr108013337280133450E0821930
chr108013345780133605E0822015
chr108013474980134835E0823307
chr108013488980134939E0823447
chr108013524280135384E0823800
chr108013540580135567E0823963
chr108013610080136538E0824658
chr108013662580136822E0825183
chr108013693480137035E0825492
chr108013708580137171E0825643
chr108013719380137506E0825751
chr108013758480137655E0826142
chr108013776080137908E0826318
chr108014025480140318E0828812
chr108014039580140618E0828953
chr108016092780160992E08229485
chr108016123680162702E08229794
chr108016596080166031E08234518
chr108016607480166139E08234632
chr108016614180166191E08234699
chr108016640780169252E08234965
chr108016929580169438E08237853
chr108017165780171929E08240215
chr108017219680172335E08240754
chr108017240380172618E08240961
chr108017262780173445E08241185
chr108017406580174115E08242623
chr108017774080177812E08246298
chr108017787080177924E08246428
chr108017798980178043E08246547
chr108017883980178969E08247397
chr108017930980179359E08247867
chr108017945980179510E08248017
chr108017958180179692E08248139
chr108017975180179824E08248309
chr108017994980179999E08248507
chr108018031780180374E08248875
chr108018049180180557E08249049
chr108018056680180626E08249124