rs10493727

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0261 (7800/29778,GnomAD)
T=0194 (5672/29118,TOPMED)
T=0201 (1007/5008,1000G)
T=0338 (1303/3854,ALSPAC)
T=0325 (1206/3708,TWINSUK)
chr1:82723138 (GRCh38.p7) (1p31.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.82723138C>T
GRCh37.p13 chr 1NC_000001.10:g.83188821C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.967T=0.033
1000GenomesAmericanSub694C=0.750T=0.250
1000GenomesEast AsianSub1008C=0.766T=0.234
1000GenomesEuropeSub1006C=0.715T=0.285
1000GenomesGlobalStudy-wide5008C=0.799T=0.201
1000GenomesSouth AsianSub978C=0.730T=0.270
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.662T=0.338
The Genome Aggregation DatabaseAfricanSub8710C=0.925T=0.075
The Genome Aggregation DatabaseAmericanSub834C=0.740T=0.260
The Genome Aggregation DatabaseEast AsianSub1540C=0.744T=0.256
The Genome Aggregation DatabaseEuropeSub18392C=0.648T=0.351
The Genome Aggregation DatabaseGlobalStudy-wide29778C=0.738T=0.261
The Genome Aggregation DatabaseOtherSub302C=0.780T=0.220
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.805T=0.194
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.675T=0.325
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs104937274.51E-05alcohol dependence21703634

eQTL of rs10493727 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10493727 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.