rs10496746

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0450 (13491/29936,GnomAD)
T=0404 (11769/29118,TOPMED)
T=0250 (1250/5008,1000G)
C==0296 (1140/3854,ALSPAC)
C==0312 (1157/3708,TWINSUK)
chr2:136449512 (GRCh38.p7) (2q22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
24 Enhancers around
17 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.136449512C>T
GRCh37.p13 chr 2NC_000002.11:g.137207082C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.919T=0.081
1000GenomesAmericanSub694C=0.620T=0.380
1000GenomesEast AsianSub1008C=0.981T=0.019
1000GenomesEuropeSub1006C=0.398T=0.602
1000GenomesGlobalStudy-wide5008C=0.750T=0.250
1000GenomesSouth AsianSub978C=0.740T=0.260
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.296T=0.704
The Genome Aggregation DatabaseAfricanSub8712C=0.833T=0.167
The Genome Aggregation DatabaseAmericanSub838C=0.630T=0.370
The Genome Aggregation DatabaseEast AsianSub1618C=0.985T=0.015
The Genome Aggregation DatabaseEuropeSub18466C=0.372T=0.627
The Genome Aggregation DatabaseGlobalStudy-wide29936C=0.549T=0.450
The Genome Aggregation DatabaseOtherSub302C=0.610T=0.390
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.595T=0.404
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.312T=0.688
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry

P-Value

SNP ID p-value Traits Study
rs104967462.6E-05alcoholism (heaviness of drinking)21529783

eQTL of rs10496746 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10496746 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2137161799137161998E070-45084
chr2137162077137162121E070-44961
chr2137162459137162513E070-44569
chr2137164507137164566E070-42516
chr2137164613137165030E070-42052
chr2137165210137165776E070-41306
chr2137166799137166849E070-40233
chr2137199698137199811E070-7271
chr2137200022137200210E070-6872
chr2137200546137200620E070-6462
chr2137254583137254828E07047501
chr2137255033137255103E07047951
chr2137255270137255637E07048188
chr2137255801137255851E07048719
chr2137255858137255960E07048776
chr2137199698137199811E071-7271
chr2137164613137165030E081-42052
chr2137165210137165776E081-41306
chr2137254583137254828E08147501
chr2137254583137254828E08247501
chr2137255033137255103E08247951
chr2137255270137255637E08248188
chr2137255801137255851E08248719
chr2137255858137255960E08248776




Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2137181038137181523E067-25559
chr2137180934137181034E068-26048
chr2137181038137181523E068-25559
chr2137181551137181658E068-25424
chr2137181038137181523E069-25559
chr2137181551137181658E069-25424
chr2137181038137181523E070-25559
chr2137181551137181658E070-25424
chr2137181038137181523E071-25559
chr2137181038137181523E072-25559
chr2137181551137181658E072-25424
chr2137181038137181523E073-25559
chr2137181038137181523E074-25559
chr2137181551137181658E074-25424
chr2137180934137181034E082-26048
chr2137181038137181523E082-25559
chr2137181551137181658E082-25424