rs10497668

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0182 (5473/29970,GnomAD)
C=0162 (4743/29118,TOPMED)
C=0164 (820/5008,1000G)
C=0186 (717/3854,ALSPAC)
C=0183 (677/3708,TWINSUK)
chr2:186349003 (GRCh38.p7) (2q32.1)
AD
GWASdb2
1   publication(s)
See rs on genome
13 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.186349003T>C
GRCh37.p13 chr 2NC_000002.11:g.187213730T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.837C=0.163
1000GenomesAmericanSub694T=0.830C=0.170
1000GenomesEast AsianSub1008T=0.894C=0.106
1000GenomesEuropeSub1006T=0.830C=0.170
1000GenomesGlobalStudy-wide5008T=0.836C=0.164
1000GenomesSouth AsianSub978T=0.790C=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.814C=0.186
The Genome Aggregation DatabaseAfricanSub8726T=0.836C=0.164
The Genome Aggregation DatabaseAmericanSub836T=0.880C=0.120
The Genome Aggregation DatabaseEast AsianSub1618T=0.902C=0.098
The Genome Aggregation DatabaseEuropeSub18488T=0.798C=0.201
The Genome Aggregation DatabaseGlobalStudy-wide29970T=0.817C=0.182
The Genome Aggregation DatabaseOtherSub302T=0.810C=0.190
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.837C=0.162
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.817C=0.183
PMID Title Author Journal
22072270Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.Wang KSJ Neural Transm (Vienna)

P-Value

SNP ID p-value Traits Study
rs104976689.48E-05alcohol withdrawal symptoms22072270

eQTL of rs10497668 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr2:187213730RP11-410E4.1ENSG00000259915.1T>C2.2822e-6-7770Frontal_Cortex_BA9
Chr2:187213730RP11-410E4.1ENSG00000259915.1T>C1.2644e-5-7770Cortex
Chr2:187213730RP11-410E4.1ENSG00000259915.1T>C9.1565e-8-7770Caudate_basal_ganglia
Chr2:187213730RP11-410E4.1ENSG00000259915.1T>C1.8646e-10-7770Putamen_basal_ganglia

meQTL of rs10497668 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2187211713187211878E067-1852
chr2187212243187212366E067-1364
chr2187212371187212451E067-1279
chr2187211713187211878E071-1852
chr2187212243187212366E071-1364
chr2187212371187212451E071-1279
chr2187167068187167335E072-46395
chr2187211713187211878E074-1852
chr2187212243187212366E074-1364
chr2187212371187212451E074-1279
chr2187213039187213214E074-516
chr2187172461187172541E081-41189
chr2187172713187173019E081-40711