rs10503364

Homo sapiens
T>C
LOC107986909 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0135 (4046/29916,GnomAD)
C=0185 (5387/29118,TOPMED)
C=0219 (1099/5008,1000G)
C=0043 (166/3854,ALSPAC)
C=0042 (157/3708,TWINSUK)
chr8:6805802 (GRCh38.p7) (8p23.1)
ND
GWASdb2
1   publication(s)
See rs on genome
96 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.6805802T>C
GRCh37.p13 chr 8NC_000008.10:g.6663323T>C

Gene: LOC107986909, uncharacterized LOC107986909(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107986909 transcriptXR_001745769.1:n....XR_001745769.1:n.1571A>GA>GNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.680C=0.320
1000GenomesAmericanSub694T=0.810C=0.190
1000GenomesEast AsianSub1008T=0.756C=0.244
1000GenomesEuropeSub1006T=0.954C=0.046
1000GenomesGlobalStudy-wide5008T=0.781C=0.219
1000GenomesSouth AsianSub978T=0.740C=0.260
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.957C=0.043
The Genome Aggregation DatabaseAfricanSub8700T=0.686C=0.314
The Genome Aggregation DatabaseAmericanSub838T=0.820C=0.180
The Genome Aggregation DatabaseEast AsianSub1612T=0.775C=0.225
The Genome Aggregation DatabaseEuropeSub18464T=0.958C=0.041
The Genome Aggregation DatabaseGlobalStudy-wide29916T=0.864C=0.135
The Genome Aggregation DatabaseOtherSub302T=0.910C=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.815C=0.185
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.958C=0.042
PMID Title Author Journal
17407593Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs.Uhl GRBMC Genet

P-Value

SNP ID p-value Traits Study
rs105033640.00063nicotine dependence17407593

eQTL of rs10503364 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10503364 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr866307976631081E067-32242
chr866311196631474E067-31849
chr866320616632111E067-31212
chr866321546632194E067-31129
chr866321956632300E067-31023
chr866325886632650E067-30673
chr866326786632807E067-30516
chr866332216633413E068-29910
chr866334806633811E068-29512
chr866338776633957E068-29366
chr866451976645852E068-17471
chr866579706659071E068-4252
chr866325886632650E069-30673
chr866326786632807E069-30516
chr866330056633106E069-30217
chr866332216633413E069-29910
chr866334806633811E069-29512
chr866451976645852E069-17471
chr866459586646009E069-17314
chr866510876651154E069-12169
chr866451976645852E070-17471
chr866500716650131E070-13192
chr866501336650183E070-13140
chr866504016650495E070-12828
chr866505116650847E070-12476
chr866938066693868E07030483
chr866939546694022E07030631
chr866311196631474E071-31849
chr866314766631855E071-31468
chr866318566632013E071-31310
chr866320616632111E071-31212
chr866321546632194E071-31129
chr866321956632300E071-31023
chr866330056633106E071-30217
chr866332216633413E071-29910
chr866334806633811E071-29512
chr866367466637848E071-25475
chr866451976645852E071-17471
chr866516436651683E071-11640
chr866517336651787E071-11536
chr866520616652245E071-11078
chr866978556699670E07134532
chr866210056621302E072-42021
chr866314766631855E072-31468
chr866330056633106E072-30217
chr866332216633413E072-29910
chr866334806633811E072-29512
chr866451976645852E072-17471
chr866579706659071E072-4252
chr866902476690359E07226924
chr866318566632013E073-31310
chr866320616632111E073-31212
chr866321546632194E073-31129
chr866321956632300E073-31023
chr866451976645852E073-17471
chr866510876651154E073-12169
chr866516436651683E073-11640
chr866517336651787E073-11536
chr866520616652245E073-11078
chr866523736652474E073-10849
chr866314766631855E074-31468
chr866318566632013E074-31310
chr866320616632111E074-31212
chr866321546632194E074-31129
chr866321956632300E074-31023
chr866325886632650E074-30673
chr866326786632807E074-30516
chr866332216633413E074-29910
chr866334806633811E074-29512
chr866338776633957E074-29366
chr866442316644328E081-18995
chr866443846644424E081-18899
chr866444966644563E081-18760
chr866449356644985E081-18338
chr866451976645852E081-17471
chr866459586646009E081-17314
chr866504016650495E081-12828
chr866505116650847E081-12476
chr866579706659071E081-4252
chr866745106674581E08111187
chr866747386674785E08111415
chr866748186674910E08111495
chr866749766675026E08111653
chr866753326675513E08112009
chr866978556699670E08134532
chr866318566632013E082-31310
chr866320616632111E082-31212
chr866321546632194E082-31129
chr866321956632300E082-31023
chr866442316644328E082-18995
chr866443846644424E082-18899
chr866444966644563E082-18760
chr866745106674581E08211187
chr866747386674785E08211415
chr866748186674910E08211495
chr866749766675026E08211653










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr866909846693664E06727661
chr866909846693664E06827661
chr866909846693664E06927661
chr866909846693664E07027661
chr866909846693664E07227661
chr866909846693664E07327661
chr866909846693664E07427661
chr866909846693664E08227661