rs10504631

Homo sapiens
A>G
ZFHX4-AS1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0186 (5585/29944,GnomAD)
G=0189 (5510/29118,TOPMED)
G=0201 (1008/5008,1000G)
G=0139 (536/3854,ALSPAC)
G=0132 (490/3708,TWINSUK)
chr8:76626252 (GRCh38.p7) (8q21.13)
ND
GWASdb2
1   publication(s)
See rs on genome
17 Enhancers around
27 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.76626252A>G
GRCh37.p13 chr 8NC_000008.10:g.77538487A>G

Gene: ZFHX4-AS1, ZFHX4 antisense RNA 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ZFHX4-AS1 transcriptNR_024360.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.726G=0.274
1000GenomesAmericanSub694A=0.870G=0.130
1000GenomesEast AsianSub1008A=0.814G=0.186
1000GenomesEuropeSub1006A=0.843G=0.157
1000GenomesGlobalStudy-wide5008A=0.799G=0.201
1000GenomesSouth AsianSub978A=0.780G=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.861G=0.139
The Genome Aggregation DatabaseAfricanSub8708A=0.725G=0.275
The Genome Aggregation DatabaseAmericanSub838A=0.890G=0.110
The Genome Aggregation DatabaseEast AsianSub1620A=0.823G=0.177
The Genome Aggregation DatabaseEuropeSub18476A=0.850G=0.149
The Genome Aggregation DatabaseGlobalStudy-wide29944A=0.813G=0.186
The Genome Aggregation DatabaseOtherSub302A=0.830G=0.170
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.810G=0.189
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.868G=0.132
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs105046310.000776nicotine dependence17158188

eQTL of rs10504631 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10504631 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr87753797877538105E067-382
chr87757928577579340E06740798
chr87749306077494344E068-44143
chr87749306077494344E069-44143
chr87753797877538105E069-382
chr87758427077584612E06945783
chr87749002377490095E071-48392
chr87749015177490329E071-48158
chr87749043477490648E071-47839
chr87749306077494344E071-44143
chr87753797877538105E071-382
chr87757928577579340E07140798
chr87758427077584612E07145783
chr87749015177490329E074-48158
chr87749043477490648E074-47839
chr87749306077494344E074-44143
chr87749306077494344E081-44143






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr87757751977577628E06739032
chr87757767777577798E06739190
chr87757781777577907E06739330
chr87757803677578355E06739549
chr87757839577578462E06739908
chr87758463677587440E06746149
chr87757751977577628E06839032
chr87757767777577798E06839190
chr87757781777577907E06839330
chr87758463677587440E06846149
chr87758463677587440E06946149
chr87758463677587440E07046149
chr87757751977577628E07139032
chr87757767777577798E07139190
chr87757781777577907E07139330
chr87757803677578355E07139549
chr87757839577578462E07139908
chr87758463677587440E07146149
chr87757751977577628E07239032
chr87757767777577798E07239190
chr87757781777577907E07239330
chr87758463677587440E07246149
chr87758463677587440E07346149
chr87757767777577798E07439190
chr87757781777577907E07439330
chr87758463677587440E07446149
chr87758463677587440E08246149