rs10511260

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0216 (6486/29924,GnomAD)
G=0189 (5529/29118,TOPMED)
G=0177 (887/5008,1000G)
G=0299 (1154/3854,ALSPAC)
G=0313 (1160/3708,TWINSUK)
chr3:107514250 (GRCh38.p7) (3q13.12)
AD
GWASdb2
4   publication(s)
See rs on genome
30 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.107514250T>G
GRCh37.p13 chr 3NC_000003.11:g.107233097T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.965G=0.035
1000GenomesAmericanSub694T=0.760G=0.240
1000GenomesEast AsianSub1008T=0.879G=0.121
1000GenomesEuropeSub1006T=0.677G=0.323
1000GenomesGlobalStudy-wide5008T=0.823G=0.177
1000GenomesSouth AsianSub978T=0.770G=0.230
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.701G=0.299
The Genome Aggregation DatabaseAfricanSub8710T=0.930G=0.070
The Genome Aggregation DatabaseAmericanSub838T=0.750G=0.250
The Genome Aggregation DatabaseEast AsianSub1620T=0.875G=0.125
The Genome Aggregation DatabaseEuropeSub18454T=0.708G=0.291
The Genome Aggregation DatabaseGlobalStudy-wide29924T=0.783G=0.216
The Genome Aggregation DatabaseOtherSub302T=0.720G=0.280
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.810G=0.189
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.687G=0.313
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry
23691058Dosage transmission disequilibrium test (dTDT) for linkage and association detection.Zhang ZPLoS One
25043041Neuropsychosocial profiles of current and future adolescent alcohol misusers.Whelan RNature

P-Value

SNP ID p-value Traits Study
rs105112600.0000034alcohol dependence(early age of onset)20201924
rs105112600.00000341alcoholismpha002892
rs105112600.00047alcohol dependence20201924

eQTL of rs10511260 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr3:107233097RP11-115H18.1ENSG00000273125.1T>G3.7244e-1483320Caudate_basal_ganglia
Chr3:107233097RP11-115H18.1ENSG00000273125.1T>G3.8154e-983320Putamen_basal_ganglia
Chr3:107233097RP11-115H18.1ENSG00000273125.1T>G1.1701e-583320Nucleus_accumbens_basal_ganglia

meQTL of rs10511260 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3107246083107246178E06712986
chr3107262693107262841E06729596
chr3107282047107282170E06748950
chr3107261510107261727E06828413
chr3107261733107261848E06828636
chr3107277480107277954E06844383
chr3107281918107282020E06848821
chr3107282047107282170E06848950
chr3107261510107261727E06928413
chr3107261733107261848E06928636
chr3107262693107262841E06929596
chr3107264590107264732E06931493
chr3107264767107264966E06931670
chr3107277480107277954E06944383
chr3107281918107282020E06948821
chr3107282047107282170E06948950
chr3107246083107246178E07112986
chr3107261510107261727E07128413
chr3107261733107261848E07128636
chr3107264590107264732E07131493
chr3107264767107264966E07131670
chr3107281918107282020E07148821
chr3107282047107282170E07148950
chr3107281918107282020E07348821
chr3107282047107282170E07348950
chr3107261510107261727E07428413
chr3107261733107261848E07428636
chr3107277480107277954E07444383
chr3107281918107282020E07448821
chr3107282047107282170E07448950






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3107241109107244988E0678012
chr3107241109107244988E0688012
chr3107241109107244988E0698012
chr3107241109107244988E0708012
chr3107241109107244988E0718012
chr3107241109107244988E0728012
chr3107241109107244988E0738012
chr3107241109107244988E0748012
chr3107241109107244988E0818012
chr3107241109107244988E0828012