rs10511261

Homo sapiens
C>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0377 (11290/29900,GnomAD)
A=0347 (10111/29118,TOPMED)
A=0305 (1528/5008,1000G)
A=0498 (1920/3854,ALSPAC)
C==0494 (1831/3708,TWINSUK)
chr3:107483777 (GRCh38.p7) (3q13.12)
AD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.107483777C>A
GRCh37.p13 chr 3NC_000003.11:g.107202624C>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.838A=0.162
1000GenomesAmericanSub694C=0.650A=0.350
1000GenomesEast AsianSub1008C=0.831A=0.169
1000GenomesEuropeSub1006C=0.483A=0.517
1000GenomesGlobalStudy-wide5008C=0.695A=0.305
1000GenomesSouth AsianSub978C=0.610A=0.390
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.502A=0.498
The Genome Aggregation DatabaseAfricanSub8718C=0.806A=0.194
The Genome Aggregation DatabaseAmericanSub838C=0.640A=0.360
The Genome Aggregation DatabaseEast AsianSub1610C=0.840A=0.160
The Genome Aggregation DatabaseEuropeSub18432C=0.518A=0.481
The Genome Aggregation DatabaseGlobalStudy-wide29900C=0.622A=0.377
The Genome Aggregation DatabaseOtherSub302C=0.450A=0.550
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.652A=0.347
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.494A=0.506
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs105112610.00027alcohol dependence20201924

eQTL of rs10511261 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr3:107202624RP11-115H18.1ENSG00000273125.1C>A3.7244e-1452847Caudate_basal_ganglia
Chr3:107202624RP11-115H18.1ENSG00000273125.1C>A3.8154e-952847Putamen_basal_ganglia

meQTL of rs10511261 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3107246083107246178E06743459
chr3107246083107246178E07143459


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3107241109107244988E06738485
chr3107241109107244988E06838485
chr3107241109107244988E06938485
chr3107241109107244988E07038485
chr3107241109107244988E07138485
chr3107241109107244988E07238485
chr3107241109107244988E07338485
chr3107241109107244988E07438485
chr3107241109107244988E08138485
chr3107241109107244988E08238485