rs10517352

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
T==0490 (14622/29826,GnomAD)
T==0461 (13443/29118,TOPMED)
T==0495 (2477/5008,1000G)
G=0497 (1917/3854,ALSPAC)
T==0493 (1829/3708,TWINSUK)
chr4:35552967 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35552967T>G
GRCh37.p13 chr 4NC_000004.11:g.35554589T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.414G=0.586
1000GenomesAmericanSub694T=0.460G=0.540
1000GenomesEast AsianSub1008T=0.704G=0.296
1000GenomesEuropeSub1006T=0.526G=0.474
1000GenomesGlobalStudy-wide5008T=0.495G=0.505
1000GenomesSouth AsianSub978T=0.380G=0.620
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.503G=0.497
The Genome Aggregation DatabaseAfricanSub8676T=0.423G=0.577
The Genome Aggregation DatabaseAmericanSub834T=0.420G=0.580
The Genome Aggregation DatabaseEast AsianSub1612T=0.741G=0.259
The Genome Aggregation DatabaseEuropeSub18402T=0.502G=0.497
The Genome Aggregation DatabaseGlobalStudy-wide29826T=0.490G=0.509
The Genome Aggregation DatabaseOtherSub302T=0.570G=0.430
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.461G=0.538
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.493G=0.507
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs105173520.000155nicotine dependence17158188

eQTL of rs10517352 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10517352 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E074-27802
chr43553670135536912E082-17677
chr43553699835537160E082-17429


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E068-27603
chr43552703435527236E068-27353
chr43552753335527608E068-26981
chr43552687235526986E069-27603
chr43552703435527236E069-27353
chr43552687235526986E071-27603
chr43552703435527236E071-27353
chr43552753335527608E071-26981
chr43552687235526986E072-27603
chr43552703435527236E072-27353
chr43552687235526986E073-27603
chr43552703435527236E073-27353
chr43552687235526986E074-27603
chr43552703435527236E074-27353