rs10521221

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0379 (11353/29932,GnomAD)
C==0455 (13259/29118,TOPMED)
C==0354 (1774/5008,1000G)
C==0256 (988/3854,ALSPAC)
C==0255 (947/3708,TWINSUK)
chr16:51096248 (GRCh38.p7) (16q12.1)
AD
GWASdb2
1   publication(s)
See rs on genome
243 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.51096248C>T
GRCh37.p13 chr 16NC_000016.9:g.51130159C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.743T=0.257
1000GenomesAmericanSub694C=0.300T=0.700
1000GenomesEast AsianSub1008C=0.057T=0.943
1000GenomesEuropeSub1006C=0.271T=0.729
1000GenomesGlobalStudy-wide5008C=0.354T=0.646
1000GenomesSouth AsianSub978C=0.260T=0.740
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.256T=0.744
The Genome Aggregation DatabaseAfricanSub8698C=0.676T=0.324
The Genome Aggregation DatabaseAmericanSub834C=0.260T=0.740
The Genome Aggregation DatabaseEast AsianSub1620C=0.068T=0.932
The Genome Aggregation DatabaseEuropeSub18480C=0.274T=0.725
The Genome Aggregation DatabaseGlobalStudy-wide29932C=0.379T=0.620
The Genome Aggregation DatabaseOtherSub300C=0.260T=0.740
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.455T=0.544
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.255T=0.745
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs105212210.000951alcohol dependence24277619

eQTL of rs10521221 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10521221 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr165109103551091095E067-39064
chr165112984251129882E067-277
chr165112993251130074E067-85
chr165113007551130156E067-3
chr165113022251130296E06763
chr165113047451130533E067315
chr165113057551130746E067416
chr165114823151148405E06718072
chr165114842251148638E06718263
chr165115292151153095E06722762
chr165115315351153214E06722994
chr165115345451153865E06723295
chr165117511651175298E06744957
chr165117913051179262E06748971
chr165109103551091095E068-39064
chr165109162151091702E068-38457
chr165109251351092604E068-37555
chr165112911651129177E068-982
chr165112922151129261E068-898
chr165112929151129378E068-781
chr165112993251130074E068-85
chr165113007551130156E068-3
chr165113022251130296E06863
chr165114823151148405E06818072
chr165114842251148638E06818263
chr165115292151153095E06822762
chr165115315351153214E06822994
chr165115345451153865E06823295
chr165117511651175298E06844957
chr165117534251175564E06845183
chr165117558651175656E06845427
chr165117764951177739E06847490
chr165117777851177826E06847619
chr165117818951178404E06848030
chr165117854351178583E06848384
chr165117876951178819E06848610
chr165117913051179262E06848971
chr165117927851179424E06849119
chr165108401651084066E069-46093
chr165108416051084220E069-45939
chr165109038051090430E069-39729
chr165109276551092815E069-37344
chr165112922151129261E069-898
chr165112929151129378E069-781
chr165112949651129770E069-389
chr165112984251129882E069-277
chr165112993251130074E069-85
chr165113007551130156E069-3
chr165113022251130296E06963
chr165113047451130533E069315
chr165113057551130746E069416
chr165114693951147583E06916780
chr165114823151148405E06918072
chr165114842251148638E06918263
chr165114874551148805E06918586
chr165115292151153095E06922762
chr165115315351153214E06922994
chr165115345451153865E06923295
chr165115407451154133E06923915
chr165117165251171806E06941493
chr165117229051172366E06942131
chr165117254051172590E06942381
chr165117279451172844E06942635
chr165117309351173143E06942934
chr165117320251173252E06943043
chr165117511651175298E06944957
chr165117534251175564E06945183
chr165117645251176520E06946293
chr165117656951176669E06946410
chr165117667151176757E06946512
chr165117685651176910E06946697
chr165117694351177084E06946784
chr165117721851177294E06947059
chr165117730651177417E06947147
chr165117749451177567E06947335
chr165117764951177739E06947490
chr165117777851177826E06947619
chr165117818951178404E06948030
chr165117854351178583E06948384
chr165117876951178819E06948610
chr165117913051179262E06948971
chr165117927851179424E06949119
chr165117945751179564E06949298
chr165117965251179752E06949493
chr165117978451179867E06949625
chr165110639151106431E070-23728
chr165110644051106662E070-23497
chr165110673251106869E070-23290
chr165112949651129770E070-389
chr165112984251129882E070-277
chr165112993251130074E070-85
chr165113007551130156E070-3
chr165113022251130296E07063
chr165113047451130533E070315
chr165113057551130746E070416
chr165114693951147583E07016780
chr165114823151148405E07018072
chr165114842251148638E07018263
chr165114874551148805E07018586
chr165116301751163341E07032858
chr165116335151163397E07033192
chr165116653751167015E07036378
chr165116703251167199E07036873
chr165116972151169802E07039562
chr165117399351174047E07043834
chr165117421151174301E07044052
chr165117440351174540E07044244
chr165117457951174639E07044420
chr165117467651174768E07044517
chr165117645251176520E07046293
chr165108211651082234E071-47925
chr165108233451082423E071-47736
chr165108245751082557E071-47602
chr165108262751082770E071-47389
chr165109038051090430E071-39729
chr165109251351092604E071-37555
chr165109264451092694E071-37465
chr165109276551092815E071-37344
chr165112922151129261E071-898
chr165112929151129378E071-781
chr165113047451130533E071315
chr165113057551130746E071416
chr165114842251148638E07118263
chr165114874551148805E07118586
chr165115292151153095E07122762
chr165115315351153214E07122994
chr165115345451153865E07123295
chr165117165251171806E07141493
chr165117511651175298E07144957
chr165117534251175564E07145183
chr165117558651175656E07145427
chr165117570951175772E07145550
chr165117656951176669E07146410
chr165117667151176757E07146512
chr165117685651176910E07146697
chr165117694351177084E07146784
chr165117721851177294E07147059
chr165117730651177417E07147147
chr165117818951178404E07148030
chr165117854351178583E07148384
chr165117876951178819E07148610
chr165117913051179262E07148971
chr165117927851179424E07149119
chr165117945751179564E07149298
chr165117965251179752E07149493
chr165117978451179867E07149625
chr165109103551091095E072-39064
chr165109162151091702E072-38457
chr165109251351092604E072-37555
chr165109264451092694E072-37465
chr165109276551092815E072-37344
chr165109343451093484E072-36675
chr165109351251093562E072-36597
chr165112872651128832E072-1327
chr165112911651129177E072-982
chr165112922151129261E072-898
chr165112929151129378E072-781
chr165113007551130156E072-3
chr165113022251130296E07263
chr165113047451130533E072315
chr165113057551130746E072416
chr165114823151148405E07218072
chr165114842251148638E07218263
chr165114874551148805E07218586
chr165117656951176669E07246410
chr165117667151176757E07246512
chr165117685651176910E07246697
chr165117694351177084E07246784
chr165117721851177294E07247059
chr165117730651177417E07247147
chr165117749451177567E07247335
chr165117764951177739E07247490
chr165117777851177826E07247619
chr165117818951178404E07248030
chr165117854351178583E07248384
chr165117876951178819E07248610
chr165117913051179262E07248971
chr165114823151148405E07318072
chr165114842251148638E07318263
chr165114874551148805E07318586
chr165117254051172590E07342381
chr165117279451172844E07342635
chr165108370351083824E074-46335
chr165108385951083913E074-46246
chr165108401651084066E074-46093
chr165108416051084220E074-45939
chr165109038051090430E074-39729
chr165109162151091702E074-38457
chr165109251351092604E074-37555
chr165109264451092694E074-37465
chr165109276551092815E074-37344
chr165112922151129261E074-898
chr165112929151129378E074-781
chr165113022251130296E07463
chr165113047451130533E074315
chr165113057551130746E074416
chr165113225351132303E0742094
chr165114693951147583E07416780
chr165114874551148805E07418586
chr165115292151153095E07422762
chr165115315351153214E07422994
chr165115345451153865E07423295
chr165115407451154133E07423915
chr165116566551165748E07435506
chr165117093751171456E07440778
chr165117165251171806E07441493
chr165117229051172366E07442131
chr165117254051172590E07442381
chr165117279451172844E07442635
chr165117511651175298E07444957
chr165117534251175564E07445183
chr165117558651175656E07445427
chr165117656951176669E07446410
chr165117667151176757E07446512
chr165117685651176910E07446697
chr165117694351177084E07446784
chr165117721851177294E07447059
chr165117730651177417E07447147
chr165117749451177567E07447335
chr165117764951177739E07447490
chr165117777851177826E07447619
chr165117818951178404E07448030
chr165117854351178583E07448384
chr165117876951178819E07448610
chr165117913051179262E07448971
chr165117927851179424E07449119
chr165117945751179564E07449298
chr165117965251179752E07449493
chr165117978451179867E07449625
chr165114823151148405E08118072
chr165114842251148638E08118263
chr165116274051163000E08132581
chr165116301751163341E08132858
chr165117093751171456E08140778
chr165117254051172590E08142381
chr165117876951178819E08148610
chr165117913051179262E08148971
chr165117093751171456E08240778
chr165117165251171806E08241493
chr165117229051172366E08242131
chr165117254051172590E08242381
chr165117656951176669E08246410
chr165117667151176757E08246512










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr165114763651147954E06717477
chr165114763651147954E06817477
chr165116766951168006E06837510
chr165116766951168006E07037510
chr165114763651147954E07117477
chr165116766951168006E07137510
chr165114763651147954E07217477
chr165114763651147954E07317477
chr165114763651147954E07417477