rs10733657

Homo sapiens
C>T
RBM18 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0071 (2156/30000,GnomAD)
C==0097 (2847/29118,TOPMED)
C==0068 (339/5008,1000G)
C==0041 (159/3854,ALSPAC)
C==0037 (139/3708,TWINSUK)
chr9:122239706 (GRCh38.p7) (9q33.2)
AD
GWASdb2
1   publication(s)
See rs on genome
137 Enhancers around
25 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.122239706C>T
GRCh37.p13 chr 9NC_000009.11:g.125001985C>T

Gene: RBM18, RNA binding motif protein 18(minus strand)

Molecule type Change Amino acid[Codon] SO Term
RBM18 transcript variant 1NM_033117.3:c.N/A3 Prime UTR Variant
RBM18 transcript variant 2NR_027125.1:n.304...NR_027125.1:n.3042G>AG>ANon Coding Transcript Variant
RBM18 transcript variant 3NR_027126.1:n.301...NR_027126.1:n.3011G>AG>ANon Coding Transcript Variant
RBM18 transcript variant X1XM_006717319.1:c.N/A3 Prime UTR Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.210T=0.790
1000GenomesAmericanSub694C=0.030T=0.970
1000GenomesEast AsianSub1008C=0.000T=1.000
1000GenomesEuropeSub1006C=0.032T=0.968
1000GenomesGlobalStudy-wide5008C=0.068T=0.932
1000GenomesSouth AsianSub978C=0.010T=0.990
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.041T=0.959
The Genome Aggregation DatabaseAfricanSub8728C=0.176T=0.824
The Genome Aggregation DatabaseAmericanSub838C=0.040T=0.960
The Genome Aggregation DatabaseEast AsianSub1622C=0.000T=1.000
The Genome Aggregation DatabaseEuropeSub18510C=0.030T=0.969
The Genome Aggregation DatabaseGlobalStudy-wide30000C=0.071T=0.928
The Genome Aggregation DatabaseOtherSub302C=0.040T=0.960
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.097T=0.902
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.037T=0.963
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs107336570.00018alcohol dependence20201924

eQTL of rs10733657 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs10733657 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr9124952939124953219E067-48766
chr9124953399124953548E067-48437
chr9124953586124953687E067-48298
chr9125002045125002095E06760
chr9125013680125014053E06711695
chr9125014253125014313E06712268
chr9125014489125014539E06712504
chr9125015079125015407E06713094
chr9125015415125015546E06713430
chr9125016522125016664E06714537
chr9125016682125016832E06714697
chr9125017015125017231E06715030
chr9125023692125023805E06721707
chr9125023860125024185E06721875
chr9125024382125024422E06722397
chr9125024501125024633E06722516
chr9125024682125024769E06722697
chr9125024779125024831E06722794
chr9125025367125025503E06723382
chr9125025551125025672E06723566
chr9125014253125014313E06812268
chr9125014489125014539E06812504
chr9125015079125015407E06813094
chr9125015415125015546E06813430
chr9125017015125017231E06815030
chr9125028756125028869E06826771
chr9124952939124953219E069-48766
chr9124953399124953548E069-48437
chr9125013680125014053E06911695
chr9125014253125014313E06912268
chr9125014489125014539E06912504
chr9125015079125015407E06913094
chr9125015415125015546E06913430
chr9125017015125017231E06915030
chr9125023692125023805E06921707
chr9125023860125024185E06921875
chr9125025367125025503E06923382
chr9125025551125025672E06923566
chr9124952939124953219E070-48766
chr9124953399124953548E070-48437
chr9124953586124953687E070-48298
chr9124953770124954062E070-47923
chr9124959798124960446E070-41539
chr9124960744124960802E070-41183
chr9124960829124960919E070-41066
chr9124961021124961086E070-40899
chr9124966136124966219E070-35766
chr9124966654124966843E070-35142
chr9124966969124967045E070-34940
chr9124967166124967344E070-34641
chr9124967583124967640E070-34345
chr9124967690124967740E070-34245
chr9124968070124968155E070-33830
chr9124968404124968480E070-33505
chr9124968537124968812E070-33173
chr9124968837124968984E070-33001
chr9124968985124969099E070-32886
chr9124971444124971502E070-30483
chr9124971630124971692E070-30293
chr9124971717124971777E070-30208
chr9124977664124977889E070-24096
chr9125024382125024422E07022397
chr9125024501125024633E07022516
chr9125024682125024769E07022697
chr9125024779125024831E07022794
chr9125025367125025503E07023382
chr9125025551125025672E07023566
chr9124985185124985573E071-16412
chr9124985740124985801E071-16184
chr9124985898124985948E071-16037
chr9124985955124986005E071-15980
chr9125013680125014053E07111695
chr9125014489125014539E07112504
chr9125015079125015407E07113094
chr9125015415125015546E07113430
chr9125016522125016664E07114537
chr9125016682125016832E07114697
chr9125017015125017231E07115030
chr9125017579125017629E07115594
chr9125017755125017805E07115770
chr9125017900125017950E07115915
chr9125025367125025503E07123382
chr9125025551125025672E07123566
chr9124952939124953219E072-48766
chr9124953399124953548E072-48437
chr9125010780125010922E0728795
chr9125010949125011313E0728964
chr9125013680125014053E07211695
chr9125014253125014313E07212268
chr9125014489125014539E07212504
chr9125015079125015407E07213094
chr9125015415125015546E07213430
chr9125017015125017231E07215030
chr9125017755125017805E07215770
chr9125017900125017950E07215915
chr9125023860125024185E07221875
chr9125024382125024422E07222397
chr9125024501125024633E07222516
chr9125024682125024769E07222697
chr9125024779125024831E07222794
chr9125025367125025503E07223382
chr9125025551125025672E07223566
chr9125013680125014053E07311695
chr9125014253125014313E07312268
chr9125014489125014539E07312504
chr9125015079125015407E07313094
chr9125015415125015546E07313430
chr9125023400125023460E07321415
chr9125023562125023662E07321577
chr9125023692125023805E07321707
chr9125023860125024185E07321875
chr9125024382125024422E07322397
chr9125024501125024633E07322516
chr9125024682125024769E07322697
chr9125024779125024831E07322794
chr9125025367125025503E07323382
chr9125025551125025672E07323566
chr9125028756125028869E07326771
chr9124985898124985948E074-16037
chr9124985955124986005E074-15980
chr9125013680125014053E07411695
chr9125014253125014313E07412268
chr9125014489125014539E07412504
chr9125015079125015407E07413094
chr9125015415125015546E07413430
chr9125016682125016832E07414697
chr9125017015125017231E07415030
chr9125025367125025503E07423382
chr9125025551125025672E07423566
chr9124966654124966843E081-35142
chr9124966969124967045E081-34940
chr9124970409124970494E081-31491
chr9124970555124970613E081-31372
chr9125024779125024831E08122794
chr9125025367125025503E08123382
chr9125025551125025672E08123566
chr9125024501125024633E08222516










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr9124990342124991948E067-10037
chr9125026240125028264E06724255
chr9124990342124991948E068-10037
chr9125026240125028264E06824255
chr9124975422124977054E069-24931
chr9124990342124991948E069-10037
chr9125026240125028264E06924255
chr9124974793124974944E070-27041
chr9124975030124975116E070-26869
chr9124975422124977054E070-24931
chr9124986358124986408E070-15577
chr9124990342124991948E070-10037
chr9125026240125028264E07024255
chr9124990342124991948E071-10037
chr9125026240125028264E07124255
chr9124990342124991948E072-10037
chr9125026240125028264E07224255
chr9125026240125028264E07324255
chr9124990342124991948E074-10037
chr9125026240125028264E07424255
chr9124975030124975116E082-26869
chr9124975422124977054E082-24931
chr9124986358124986408E082-15577
chr9124990342124991948E082-10037
chr9125026240125028264E08224255